External radiation of the parotid glands significantly reduces drooling in patients with motor neurone disease with bulbar paresis

Andersen, Peter M.; Grönberg, Henrik; Franzén, Lars; Funegård, Ulrika

doi:10.1016/s0022-510x(01)00631-1

Cited by 74 publications

(63 citation statements)

References 15 publications

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“…15 A "satisfactory response" was observed and saliva secretion rate diminished with a single dose of 7-7.5 Gy bilaterally (Class III). 16 Conclusions. In patients with medically refractory sialorrhea, BTxB injections into the parotid and submandibular glands are probably effective (1 Class I study).…”

Section: What Are the Most Effective Treatments For Sialorrhea?mentioning

confidence: 99%

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review)

Miller¹,

Jackson²,

Kasarskis³

et al. 2009

Neurology

557

417

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Objective: To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). Methods:The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking the news, multidisciplinary clinics, symptom management, cognitive and behavioral impairment, communication, and palliative care for patients with ALS.

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Section: What Are the Most Effective Treatments For Sialorrhea?mentioning

confidence: 99%

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review)

Miller¹,

Jackson²,

Kasarskis³

et al. 2009

Neurology

557

417

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“…Anti-cholinergic drugs are effective for this option, though poorly tolerated. Invasive procedures, such as parotid gland irradiation, salivary gland ligation or excision are recommended in strictly selected cases [2,3].…”

Section: Introductionmentioning

confidence: 99%

Long-lasting benefits of botulinum toxin type B in Parkinson’s disease-related drooling

et al. 2009

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“…59 Several studies on radiotherapy for the treatment of sialorrhea in ALS adopted different techniques (electron-based therapy vs photon-based therapy) and doses (Table 4). Electron-based therapy appears to be well tolerated and induces a sustained improvement compared with photon-based therapy, with no serious side effects.…”

Section: Radiotherapymentioning

confidence: 99%

A Review of Options for Treating Sialorrhea in Amyotrophic Lateral Sclerosis

et al. 2014

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Sialorrhea or drooling represents quite a common problem in patients with amyotrophic lateral sclerosis (ALS). In this review, we describe the possible treatments for this issue. Current medical management is not always effective: anticholinergic drugs (atropine, glycopyrrolate, amitriptyline, hyoscyamine, and transdermal scopolamine) are often used, but there is very little evidence of their effectiveness in patients with ALS. More invasive treatments, such as botulinum toxin injections and/or radiation therapy in the salivary glands, can be considered when anticholinergic drugs are not effective. In this review, we also explore the possible surgical options for treatment of sialorrhea. Although no specific studies have been conducted on patients with ALS, surgical therapies might represent a valid option for treatment of sialorrhea since there is no tachyphylaxis or need for repeated therapeutic sessions.

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External radiation of the parotid glands significantly reduces drooling in patients with motor neurone disease with bulbar paresis

Cited by 74 publications

References 15 publications

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review)

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review)

Long-lasting benefits of botulinum toxin type B in Parkinson’s disease-related drooling

A Review of Options for Treating Sialorrhea in Amyotrophic Lateral Sclerosis

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