External Magnetic Field-Enhanced Chemo-Photothermal Combination Tumor Therapy via Iron Oxide Nanoparticles

Abstract

The development of multifunctional nanoplatforms based on magnetic nanoparticles (MNPs) has attracted increasing attention. MNPs especially exhibit excellent responsiveness under the guidance of an external magnetic field (MF), resulting in tumor-specific, targeted delivery. The behavior and magnetic-targeting efficiency of MNPs largely depend on their physiochemical properties, especially the particle size; however, the optimal size range may vary across the multiple bioapplications associated with multifunctional nanoparticles. The optimal size range of nanoparticles for external MF-mediated targeted delivery has rarely been reported. In this work, we synthesized a series of monodisperse FeO nanoparticles with identical surface properties ranging in size from 10 to 310 nm, and we systematically investigated their behavior and MF-assisted antitumor efficacy. Our data indicated that smaller FeO nanoparticles exhibited greater cellular internalization, while larger FeO nanoparticles showed greater tumor accumulation. Larger FeO nanoparticles exhibited stronger magnetic responsiveness both in vitro and in vivo, which could be used to further induce increased accumulation of nanoparticles and their payload (e.g., doxorubicin) into the tumor site under the guidance of an external MF. Our work demonstrated that larger FeO nanoparticles, with a diameter of up to 310 nm, exhibited the best magnetic-targeting efficiency mediated by an external MF and the strongest antitumor efficacy from combination photothermal-chemotherapy. Our results could serve as a valuable reference for the future design of MNPs and their targeted delivery via the modulation of an external MF.

Self-assembly of chemically modified graphene sheets in an external magnetic field

“…4 can be described by self-assembly theory of magnetic-eld induction. [34][35][36] The modied APTES/Fe 3 O 4 nanoparticle becomes equivalent magnetic doublet under magnetic eld induction, which forms the directional induction force along the external-eld direction. The GOF sheets could be aligned along the direction of the easily magnetized axle under an external magnetic eld.…”

Opportunities and challenges of the interdisciplinary research of high magnetic fields and life sciences & healthcare

“…铁是典型的顺磁性物质, 铁 与磁场之间的天然联系提示了体内铁代谢可能受强磁场 http://engine.scichina.com/doi/10.1360/N972018-00993 的调节, 目前已有研究证实强磁场影响细胞内铁元素的代 谢 [24] . 鉴于"铁死亡"在清除癌细胞、肿瘤抑制中的潜在应 用, 利用强磁场对铁代谢的调节作用来达到肿瘤等疾病的 治疗和健康状态的调控, 有可能成为一种新的策略 [2,25,26] . [28,29] .…”

“…此外, 强磁场还可以引导磁性药物载体到达病灶部位浓聚, 达到多种治疗药物增敏及靶向治疗的作用, 也是近期肿瘤 化学治疗领域的新进展之一 [3] . 复旦大学、浙江大学等单 位 的 研 究 工 作 在 国 内 外 有 较 大 影 响 , 产 出 了 创 新 成 果 [2,26,27] . 美国德雷塞尔大学等研究机构的研究人员发现 如果能够延长磁性纳米颗粒载体的循环时间和增强表面 识别能力, 这将能够提高磁靶向递药系统的效率和药物在 靶点的作用效果 [32] .…”

“…国内外强磁场下物理、 化学、材料等学科领域的研究和应用已比较深入和系统. 相 比 之 下 , 除 了 核 磁 共 振 波 谱 (nuclear magnetic resonance, NMR)的生物物质分析和磁共振成像 ( (2) 基于医药磁性纳米材料的发 展, 推动了磁场控制药物体内靶向的研究和应用 [2,3] ; (3) 国内超导材料研究和制造技术不断发展, 低温和高温超导 材料和技术进展迅速; (4) 旋转磁场作为一种新型的健康 理疗设备, 在特殊环境下的人体健康和单兵战斗力保障, http://engine.scichina.com/doi/10.1360/N972018-00993 以及慢病的调理等方面得到初步应用; (5) 基于强磁场技 术的新型医疗仪器也在不断研发; (6) 国内"铁代谢"领域 的生物医学基础研究发展迅速 [4] , 在一些方向取得重要突 破, 为利用强磁场开展机体健康调控和疾病治疗提供了生 物医学基础支撑; (7) 国内大梯度强磁场研究技术被用于 建立抗磁悬浮平台, 在国家"载人航天工程"项目任务中开 展了模拟空间失重环境的生命科学研究 [5] ; 8 [5,19~21] .…”

Magnetic Bead-Based Sandwich Immunoassay for Viral Pathogen Detection by Employing Gold Nanoparticle as Carrier

“…On one hand, magnetic nanoparticles (MNPs) have been demonstrated to possess an intrinsic enzyme mimetic activity similar to that of the natural peroxidases, which can be further used to construct highly sensitive and selective sensors for metal ions [5], glucose [6], proteins [7], and DNA [8] through their catalytic oxidation of various substrates. On the other hand, the superparamagnetic property of magenetic beads (MBs), which can be magnetically controlled with an external magnetic field and immediately redispersed with the removing of magnet, offer a great potential for numerous biomedical applications, such as cell separation [9], automated DNA/RNA extraction [10], gene targeting [11], and drug delivery [12]. Moreover, when coated with, for example, an antibody, they can act as ideal solid supports in immunoassays because of their biocompatibility, stability, and easy surface modification, allowing a straightforward method to capture target analytes of interest from large volume samples without pre-enrichment or purification steps.…”