External ion accumulation of low molecular weight poly(ethylene glycol) by electrospray ionization fourier transform mass spectrometry

Maziarz, E. Peter; Baker, Gary A.; Lorenz, Sarah A.; Wood, Troy D.

doi:10.1016/s1044-0305(99)00099-9

Cited by 19 publications

(14 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, further extending IAT will reduce both the velocity and the kinetic energy of ions accumulated in the hexapole due to extended collisions with neutrals. 44 Thus, loss of ions accumulated in the hexapole with longer IAT may occur.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Ion Accumulation Time Dependent Molecular Characterization of Natural Organic Matter Using Electrospray Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Cao

Geng

et al. 2016

Anal. Chem.

View full text Add to dashboard Cite

Natural organic matter (NOM) is a complex organic mixture and plays a crucial role in environmental processes. By using Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS), detailed molecular information on NOM could be achieved. In this paper, ion accumulation time (IAT), a key parameter of FTICR-MS for complex mixture detection, was the focus, and its effect on the molecular characterization of NOM by FTICR-MS was systematically investigated. A notable feature of selective detection of NOM molecules by FTICR-MS with different IAT was observed. Most of the polar molecules with high O/C ratio (O/C ratio >0.5) could be easily detected by FTICR-MS with a short IAT, but extending IAT led to the ion intensities of these molecules decreasing or even disappearing. Meanwhile, a large number of unsaturated and aromatic molecules with low O/C ratio (O/C ratio <0.6) and low polarity, all of which could not be observed with a short IAT, were remarkably detected by extending IAT. Results also revealed that the unsaturated and aromatic molecules, which could only be observed by extending the IAT, were not generated by the fragmentation of molecules in NOM or from the dissociation of NOM aggregations but originally existed in NOM samples. The selective detection of NOM molecules caused by IAT extension was possibly attributed to their different polarity and different stability in the collision cell. On the basis of these results, a novel strategy of combining mass spectrometric data of NOM obtained with different IAT by FTICR-MS was proposed. With this strategy, more than 4715 CHO-molecular formulas were assigned, where about 2000 more formulas were obtained in comparison with using a short IAT (2733 CHO-molecular formulas identified) solely. The strategy is simple and robust and can be used as an alternative method to obtain more molecular information on NOM in the environment.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

Ion Accumulation Time Dependent Molecular Characterization of Natural Organic Matter Using Electrospray Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Cao

Geng

et al. 2016

Anal. Chem.

View full text Add to dashboard Cite

show abstract

“…However, it is well known that different source parameters, such as the cone voltage, can modify the ion distribution. However, such voltages influence the ion distributions only after the electrospray process 34…”

Section: Resultsmentioning

confidence: 99%

“…However, such voltages influence the ion distributions only after the electrospray process. [34] Ion-mobility measurements: Having identified the charged state and the number n of monomer units for each mass-tocharge ratio in the electrospray spectrum, the ion-mobility measurements were performed on the cations observed in Figure 1 b, c, that is, 17 < n < 28 and 21 < n < 36 for the doubly and triply charged cations, respectively. The arrivaltime distributions are reported in Figure 2 a together with the corresponding mass-to-charge ratios (2D plot).…”

Section: Resultsmentioning

confidence: 99%

Size Dependence of the Folding of Multiply Charged Sodium Cationized Polylactides Revealed by Ion Mobility Mass Spectrometry and Molecular Modelling

Winter

Lemaur

Ballivian

et al. 2011

Chemistry A European J

View full text Add to dashboard Cite

Ion mobility spectrometry coupled with mass spectrometry was used to experimentally determine the three-dimensional structure of multiply charged sodium cationized polylactides (PLA). In particular, the experiments were conducted to evaluate the influence of the charge state and the size on the gas-phase conformation of cationized PLA. The measured collision cross sections were then compared to calculated values obtained by computational chemistry methods. The most striking feature was the experimental and theoretical observation of a breaking point in the quasilinear relationship between the average collision cross sections and the number of monomer units for the triply charged cations. This breaking point was theoretically demonstrated, for the doubly and triply charged cations, to be associated with a significant folding of the polymer chains around the cationizing agents. The occurrence of such breaking points could be exploited to correlate the charge state of the most intense ion series observed upon electrospray ionization with the number-average molecular mass of a polymer.

show abstract

“…These shifts in charge state distribution were attributed to charge stripping or charge transfer to the background gas in the linear trap, which contained traces of solvents from the source; methods to limit solvent migration into the linear trap (lower ESI flow rates, higher inlet capillary temperatures, smaller diameter capillary or skimmer) reduced mass discrimination caused by charge stripping (Senko et al, 1997). Wood and co-workers provided a similar explanation in their study of ions of 2,000 Da poly(ethylene glycol) (PEG) accumulated in a linear hexapole ion trap (2 Â 10 À3 mbar), and then injected into an FTMS (Maziarz et al, 1999). Ion accumulation in the linear trap for 1 sec showed both singly and doubly charged ions, whereas ions accumulated for 5 sec showed only singly charged ions.…”

Section: B Mass Discrimination Effectsmentioning

confidence: 97%

Linear ion traps in mass spectrometry

Douglas

Frank

Mao

2004

Mass Spectrometry Reviews

391

342

View full text Add to dashboard Cite

Linear ion traps are finding new applications in many areas of mass spectrometry. In a linear ion trap, ions are confined radially by a two-dimensional (2D) radio frequency (RF) field, and axially by stopping potentials applied to end electrodes. This review focuses on linear ion trap instrumentation. Potentials and ion motion in linear multipole fields and methods of ion trapping, cooling, excitation, and isolation are described. This is followed by a description of various mass discrimination effects that have been reported with linear ion traps. Linear ion traps combined in various ways with three-dimensional (3D) traps, time-of-flight (TOF) mass analyzers, and Fourier transform ion cyclotron resonance mass spectrometers are then given. Linear ion traps can be used as stand alone mass analyzers, and their use for mass analysis by Fourier transforming image currents, by mass selective radial ejection, and by mass selective axial ejection are reviewed.

show abstract

External ion accumulation of low molecular weight poly(ethylene glycol) by electrospray ionization fourier transform mass spectrometry

Cited by 19 publications

References 53 publications

Ion Accumulation Time Dependent Molecular Characterization of Natural Organic Matter Using Electrospray Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Ion Accumulation Time Dependent Molecular Characterization of Natural Organic Matter Using Electrospray Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Size Dependence of the Folding of Multiply Charged Sodium Cationized Polylactides Revealed by Ion Mobility Mass Spectrometry and Molecular Modelling

Linear ion traps in mass spectrometry

Contact Info

Product

Resources

About