Arid area is very sensitive to global warming and are extremely vulnerable to climate change. Moreover, the water resources system in the arid area is fragile and will undergo tremendous changes with climate change. Therefore, the interaction of climate and hydrology in arid area has an important impact on the formation of regional microclimate and hydrological changes. Daihai Lake is a typical closed inland lake in arid area of China, and a key area for ecological protection in North China. In this paper, WRF-Hydro model is used to simulate the climate hydrological coupling situation of Daihai Basin from 1980 to 2020, and the coupling results are verified and calibrated by meteorological statistics, runoff calculation and remote sensing analysis. Based on the synopsis of climate and hydrology in the past 40 years, the causes and future trends of the hydrological elements in Daihai Basin are analyzed. Through the analysis, it is found that the interannual variation of precipitation in Daihai Basin is sharp, with 401.75 mm as the average from 1980 to 1994; and drastic fluctuations from 1995 to 2011, with a difference of nearly 400 mm between the interannual maximum and minimum; From 2012 to 2020, the fluctuation is small. Although the interannual variation of evaporation fluctuated, it showed an upward trend with a slope of 8.855 mm/year. The annual average temperature showed an obvious upward trend with a slope of 0.040 °C/year. From 1980 to 2020, the inflow of Daihai Lake shows a downward trend; Since 2013, the runoff into the lake has tended to be flat. Climate change and human activities are the decisive factors leading to the change of water quantity in Daihai, among which human activities play a greater role. Cultivated land irrigation and industrial water use are highly correlated with the lake discharge, and these two factors have a great influence on the lake discharge. If the current agricultural and industrial water consumption does not increase, Daihai still has a lifespan of nearly 120 years. If human activities do not change and any protective measures are not taken in time, under the background of global climate change, the flow of the Daihai Lake into the lake will be reduced to zero in 2025, and the Daihai Lake will completely dry up in 2031–2033. The study of climate hydrological coupling of long time series in Daihai Basin can not only make up for the lack of runoff data, but also provide the basis for water resources management, disaster prevention and mitigation.