External focused ultrasound treatment for neuropathic pain induced by common peroneal nerve injury

Prabhala, Tarun; Hellman, Abigail; Walling, Ian; Maietta, Teresa; Jiang, Qian; Burdette, Clif; Neubauer, Paul; Shao, Miriam M; Stapleton, Amelia; Thibodeau, Juliette; Pilitsis, Julie G.

doi:10.1016/j.neulet.2018.07.037

Cited by 23 publications

(18 citation statements)

References 18 publications

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“…Despite several studies showed the neurological therapeutic applications of lesional FUS and FUS mediated BBB opening in different diseases like essential tremor (51–54), Parkinson's disease (55–57), depression (58, 59), obsessive-compulsive disorder (60, 61), neuropatic pain (62, 63), Alzheimer disease (46, 64), only two studies explored in humans the therapeutic efficacy of tUS (9) and tFUS (11) bioelectrical neuromodulation (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Transcranial Focused Ultrasound (tFUS) and Transcranial Unfocused Ultrasound (tUS) Neuromodulation: From Theoretical Principles to Stimulation Practices

2019

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Transcranial focused ultrasound is an emerging technique for non-invasive neurostimulation. Compared to magnetic or electric non-invasive brain stimulation, this technique has a higher spatial resolution and can reach deep structures. In addition, both animal and human studies suggest that, potentially, different sites of the central and peripheral nervous system can be targeted by this technique. Depending on stimulation parameters, transcranial focused ultrasound is able to determine a wide spectrum of effects, ranging from suppression or facilitation of neural activity to tissue ablation. The aim is to review the state of the art of the human transcranial focused ultrasound neuromodulation literature, including the theoretical principles which underlie the explanation of the bioeffects on neural tissues, and showing the stimulation techniques and parameters used and their outcomes in terms of clinical, neurophysiological or neuroimaging results and safety.

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Section: Resultsmentioning

confidence: 99%

Transcranial Focused Ultrasound (tFUS) and Transcranial Unfocused Ultrasound (tUS) Neuromodulation: From Theoretical Principles to Stimulation Practices

2019

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“…LIFUS (14-93 W/cm 2 ) has been used to modulate rat vagus and sciatic nerves [ 15 , 103 ], among others, showing promising results to control NP. Damage to the common peroneal nerve causes NP responsive to mechanical stimuli, and this may be reduced by FUS even 48 h after a single application to the DRG [ 104 ].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Ultrasound Neuromodulation in Decreasing Neuropathic Pain: Clinical and Experimental Evidence

Pérez-Neri

González-Aguilar

Sandoval

et al. 2021

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Background: For more than seven decades, ultrasound has been used as an imaging and diagnostic tool. Today, new technologies - as focused ultrasound (FUS) neuromodulation - has revealed some innovative, potential applications. However, those applications have been barely studied to deal with neuropathic pain (NP), a cluster of chronic pain syndromes with a restricted response to conventional pharmaceuticals. Objective: To analyze the therapeutic potential of low-intensity (LIFUS) and high-intensity (HIFUS) FUS for managing NP. Methods: We performed a narrative review, including clinical and experimental ultrasound neuromodulation studies published in three main database repositories. Discussion: Evidence shows that FUS may influence several mechanisms relevant for neuropathic pain managing as modulation of ion channels, glutamatergic neurotransmission, cerebral blood flow, inflammation and neurotoxicity, neuronal morphology and survival, nerve regeneration, and remyelination. Some experimental models have shown that LIFUS may reduce allodynia after peripheral nerve damage. At the same time, a few clinical studies support its beneficial effect on reducing pain in nerve compression syndromes. In turn, Thalamic HIFUS ablation can reduce NP from several etiologies with minor side-effects, but some neurological sequelae might be permanent. HIFUS is also effective useful in lowering non-neuropathic pain in several disorders. Conclusion: Although an emerging set of studies brings new evidence on the therapeutic potential of both LIFUS and HIFUS for managing NP with minor side-effects, we need more controlled clinical trials to conclude about its safety and efficacy.

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“…For von Frey filament (VFF) analysis, animals were analyzed both at 20 and 60 days after injury, as described (Prabhala et al, 2018). The VFF test was used to assess mechanical threshold using the Dixon up‐down method (Dixon, 1991).…”

Section: Methodsmentioning

confidence: 99%

YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration

Jeanette

Marziali

Bhatia

et al. 2020

Glia

Self Cite

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YAP and TAZ are effectors of the Hippo pathway that controls multicellular development by integrating chemical and mechanical signals. Peripheral nervous system development depends on the Hippo pathway. We previously showed that loss of YAP and TAZ impairs the development of peripheral nerve as well as Schwann cell myelination. The role of the Hippo pathway in peripheral nerve regeneration has just started to be explored. After injury, Schwann cells adopt new identities to promote regeneration by converting to a repair‐promoting phenotype. While the reprogramming of Schwann cells to repair cells has been well characterized, the maintenance of such repair phenotype cannot be sustained for a very long period, which limits nerve repair in human. First, we show that short or long‐term myelin maintenance is not affected by defect in YAP and TAZ expression. Using crush nerve injury and conditional mutagenesis in mice, we also show that YAP and TAZ are regulators of repair Schwann cell proliferation and differentiation. We found that YAP and TAZ are required in repair Schwann cells for their redifferentiation into myelinating Schwann cell following crush injury. In this present study, we describe how the Hippo pathway and YAP and TAZ regulate remyelination over time during peripheral nerve regeneration.

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External focused ultrasound treatment for neuropathic pain induced by common peroneal nerve injury

Cited by 23 publications

References 18 publications

Transcranial Focused Ultrasound (tFUS) and Transcranial Unfocused Ultrasound (tUS) Neuromodulation: From Theoretical Principles to Stimulation Practices

Transcranial Focused Ultrasound (tFUS) and Transcranial Unfocused Ultrasound (tUS) Neuromodulation: From Theoretical Principles to Stimulation Practices

Therapeutic Potential of Ultrasound Neuromodulation in Decreasing Neuropathic Pain: Clinical and Experimental Evidence

YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration

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