External beam radiation therapy with or without high-dose-rate intraluminal brachytherapy for patients with superficial esophageal carcinoma

Nishimura, Yasumasa; Okuno, Yoshishige; Ono, Koji; Mitsumori, Michihide; Nagata, Yasushi; Hiraoka, Masahiro

doi:10.1002/(sici)1097-0142(19990715)86:2<220::aid-cncr5>3.0.co;2-o

Cited by 40 publications

(26 citation statements)

References 25 publications

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“…Following RT alone or CRT, 60 patients (36%) in group A were treated with IBT. The preference for IBT was heavily dependent on the institutional policy [9][10][11][12]25].…”

Section: Discussionsupporting

confidence: 54%

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Clinical practice and outcome of radiotherapy for esophageal cancer between 1999 and 2003: the Japanese Radiation Oncology Study Group (JROSG) Survey

et al. 2011

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“…Following RT alone or CRT, 60 patients (36%) in group A were treated with IBT. The preference for IBT was heavily dependent on the institutional policy [9][10][11][12]25].…”

Section: Discussionsupporting

confidence: 54%

“…For superficial esophageal cancer (T1N0M0), RT alone with or without intraluminal brachytherapy (IBT) is also as effective as concurrent CRT [11][12][13][14]. Recently, a phase II clinical trial of concurrent CRT for superficial esophageal cancer with submucosal invasion has been reported by the Japan Clinical Oncology Group (JCOG) [15].…”

Section: Introductionmentioning

confidence: 99%

Clinical practice and outcome of radiotherapy for esophageal cancer between 1999 and 2003: the Japanese Radiation Oncology Study Group (JROSG) Survey

et al. 2011

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“…Furthermore, previous reports have proven that RT is a safe and effective treatment modality for SMEC patients (15)(16)(17)(18)(19)(20). Therefore, RT may replace surgery as a curative and conservative treatment for medically inoperable or elderly SMEC patients.…”

Section: Introductionmentioning

confidence: 46%

“…However, the advantage conferred by intraluminal brachytherapy (IBT) in the management of SEC is still controversial (15)(16)(17). A recent retrospective report by the Japanese Society of Therapeutic Radiology and Oncology Study Group did not validate the efficacy of IBT (16).…”

Section: Introductionmentioning

confidence: 99%

Usefulness of Intraluminal Brachytherapy Combined With External Beam Radiation Therapy for Submucosal Esophageal Cancer: Long-Term Follow-Up Results

Ishikawa

Nonaka

Sakurai

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…The cause-specifi c survival curves for mucosal cancer and submucosal cancer were signifi cantly different: the 5-year cause-specifi c survivals for mucosal and submucosal cancers were 100% and 75%, respectively. Nishimura et al [9] have also reported the safety and effectiveness of external-beam radiation therapy with or without intraluminal brachytherapy for treating superfi cial esophageal cancers without any lymph node involvement. Twenty-one patients treated by external-beam radiotherapy were analyzed: 8 of these were treated by 60-69 Gy external beam alone, and the remaining 13 were treated with intraluminal brachytherapy (8-12 Gy) after 50-56 Gy externalbeam radiotherapy.…”

Section: Treatments For Superfi Cial Esophageal Cancermentioning

confidence: 99%

Nonsurgical treatments for submucosal esophageal squamous cell carcinomas

2007

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Esophageal cancer is a disease with a poor prognosis. As with superfi cial esophageal cancers, lymph node metastases are seen rarely if the tumors are limited to the epithelium or lamina propria, but when cancers invade the submucosa, there is a high incidence of lymph node involvement. Surgery with radical lymph node dissection is a standard treatment for treating submucosal esophageal cancers. However, it is usually associated with a reduced level of quality of life for the patients, who are often elderly and have various medical complications making them unfi t for aggressive surgery. According to these background indications, various nonsurgical treatments have been developed to preserve the esophagus and to achieve a less invasive cure for such patients. Defi nitive radiotherapy could be a treatment option for patients with superfi cial carcinomas, particularly for those with mucosal cancers with an unresectable width by endoscopic mucosal resection (EMR). Although there have been some retrospective analyses with a small number of patients, they could not draw defi nitive conclusions. Defi nitive chemoradiotherapy has become one of the treatment options for patients who desire nonsurgical treatment. It has shown similar survival rates with those seen for radical surgery in two retrospective analyses and one multicenter prospective phase II study. The combination of primary EMR and prophylactic chemoradiotherapy has also shown promising results with less invasiveness than surgery. These nonsurgical approaches are now under evaluation in two multi-institutional studies run by the Japan Clinical Oncology Group (JCOG), which will clarify the optimal treatment for this disease.

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External beam radiation therapy with or without high-dose-rate intraluminal brachytherapy for patients with superficial esophageal carcinoma

Cited by 40 publications

References 25 publications

Clinical practice and outcome of radiotherapy for esophageal cancer between 1999 and 2003: the Japanese Radiation Oncology Study Group (JROSG) Survey

Clinical practice and outcome of radiotherapy for esophageal cancer between 1999 and 2003: the Japanese Radiation Oncology Study Group (JROSG) Survey

Usefulness of Intraluminal Brachytherapy Combined With External Beam Radiation Therapy for Submucosal Esophageal Cancer: Long-Term Follow-Up Results

Nonsurgical treatments for submucosal esophageal squamous cell carcinomas

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