External Beam Radiation Therapy: A Treatment Modality in Diffuse Tracheobronchial Amyloidosis

Almadana, Virginia; Luque, Estefanía; Wals, Amadeo; Montemayor, Teodoro

doi:10.1016/j.arbr.2015.09.003

Cited by 7 publications

(2 citation statements)

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“…Radiotherapy targeting the presumed clonal proliferation seems to be a useful treatment method for localized amyloidosis and is effective for stopping the progression of disease and improving symptoms caused by localized amyloidosis (9). In localized laryngeal or tracheobronchial amyloidosis, radiotherapy with or without debulking surgery has been performed for local control of progressive legions and was associated with good results (50)(51)(52)(53)(54)(55). Among the cases identified in our review of the literature on localized sinonasal amyloidosis, only one case was treated with radiotherapy (36 Gy), which achieved good local control and good symptomatic improvement (31).…”

Section: Discussionmentioning

confidence: 99%

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Localized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature

et al. 2021

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Amyloidosis is a disorder of protein folding in which various proteins automatically aggregate into a highly abnormal fibrillar conformation. Amyloidosis is classified into systemic and localized forms depending on whether the abnormal proteins deposited in several different organs or only a single organ. In localized amyloidosis of the head and neck regions, laryngeal amyloidosis is common; however, localized amyloidosis of the nose is extremely rare. We herein report a case of localized amyloidosis of the nose and review the relevant literature on localized sinonasal amyloidosis. A 41-year-old man presented with a history of severe nasal obstruction, which had persisted for two decades. Nasal endoscopy and imaging studies showed extensive thickening of the bilateral nasal mucosa and diffuse submucosal deposition of calcification. After histopathological and systemic examinations, he was diagnosed with localized amyloidosis of the nasal mucosa. Septoplasty and bilateral inferior turbinoplasty, which consisted of mucosal resection using an ultrasonic bone curette, was performed and his symptoms markedly improved. Localized sinonasal amyloidosis has a good prognosis and surgical resection should be selected as a first-line treatment; however, clinicians should recognize the high probability of recurrence.

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Section: Discussionmentioning

confidence: 99%

“…The appropriate dose of radiotherapy to treat localized amyloidosis has not yet been established (56). In the case of airway amyloidosis, doses of 20-45 Gy have been reported (50)(51)(52)(53)(54)(55). Further studies are required to determine the adequate dose or scheduling of radiation therapy for localized sinonasal amyloidosis.…”

Section: Discussionmentioning

confidence: 99%