Abstract:BACKGROUNDFluralaner is the first isoxazoline ectoparasiticide developed to protect companion animals from fleas and ticks. Fluralaner primarily inhibits arthropod γ‐aminobutyric acid receptors (GABARs), which are ligand‐gated ion channels comprising five subunits arranged around the channel pore. We previously reported that the action site of fluralaner resides at the M1–M3 transmembrane interface between adjacent GABAR subunits. To investigate whether fluralaner interacts with the second transmembrane segmen… Show more
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