Extenuating role of lycopene against 254-nm UV-C radiation-mediated damages in Allium cepa L. roots

Çavuşoğlu, Dilek; Macar, Tuğçe Kalefetoğlu; Macar, Oksal; Yalçın, Emine; Çavuşoğlu, Kültiğin

doi:10.1007/s11356-021-14047-6

Cited by 7 publications

(3 citation statements)

References 62 publications

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“…UVA's detrimental effect on DNA is associated with excessive ROS formation that induces oxidative DNA damage via indirect photosensitizing reactions [52]. UVB and UVC (shorter wavelength) are directly absorbed by DNA-forming photo-dimers at di-pyrimidine sites [14,15,51].…”

Section: Discussionmentioning

confidence: 99%

“…UVC exposure has become a crucial risk for living organisms due to its widespread use in sterilization and food preservation processes [52]. In addition, the necessity of placing the UVC unit very close to the target was also considered a disadvantage.…”

Section: Discussionmentioning

confidence: 99%

“…The severe damaging effect of UVC arises from the fact that the wavelength of 254 nm, which is often used in sterilization, is very close to the peak of DNA absorption (253.7 nm) and can effectively eliminate microorganisms such as bacteria, fungi, viruses, and spores. Despite its important and numerous applications, UVC radiation is cytotoxic, detrimental to the human cornea, and promotes the development of malignant tumors [14,52]. UV radiation is a critical factor in the onset and progression of a variety of skin disorders.…”

Section: Discussionmentioning

confidence: 99%

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The Prophylactic Effect of Vitamin C and Vitamin B12 against Ultraviolet-C-Induced Hepatotoxicity in Male Rats

et al. 2023

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Ultraviolet C (UVC) devices are an effective means of disinfecting surfaces and protecting medical tools against various microbes, including coronavirus. Overexposure to UVC can induce oxidative stress, damage the genetic material, and harm biological systems. This study investigated the prophylactic efficacy of vitamin C and B12 against hepatotoxicity in UVC-intoxicated rats. Rats were irradiated with UVC (725.76, 967.68, and 1048.36 J/cm2) for 2 weeks. The rats were pretreated with the aforementioned antioxidants for two months before UVC irradiation. The prophylactic effect of vitamins against UVC hepatotoxicity was evaluated by monitoring the alteration of liver enzyme activities, antioxidant status, apoptotic and inflammatory markers, DNA fragmentation, and histological and ultrastructural alterations. Rats exposed to UVC showed a significant increase in liver enzymes, oxidant–antioxidant balance disruption, and increased hepatic inflammatory markers (TNF-α, IL-1β, iNOS, and IDO-1). Additionally, obvious over-expression of activated caspase-3 protein and DNA fragmentation were detected. Histological and ultrastructural examinations verified the biochemical findings. Co-treatment with vitamins ameliorated the deviated parameters to variable degrees. In conclusion, vitamin C could alleviate UVC-induced hepatotoxicity more than vitamin B12 by diminishing oxidative stress, inflammation, and DNA damage. This study could provide a reference for the clinical practice of vitamin C and B12 as radioprotective for workers in UVC disinfectant areas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Prophylactic Effect of Vitamin C and Vitamin B12 against Ultraviolet-C-Induced Hepatotoxicity in Male Rats

et al. 2023

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Comparative investigation of toxicity induced by UV-A and UV-C radiation using Allium test

Çavuşoğlu

Macar

et al. 2022

Environ Sci Pollut Res

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Organisms are increasingly exposed to ultraviolet (UV) rays of sunlight, due to the thinning of the ozone layer and its widespread use in sterilization processes, especially against the SARS-CoV-2 virus. The present study was conducted with the purpose of evaluating the damages of UV-A and UV-C radiations in Allium cepa L. roots. The effects of two different types of UV on some physiological, biochemical, cytogenotoxic, and anatomical parameters were investigated in a multifaceted study. Three groups were formed from Allium bulbs, one of which was the control group. One of the other groups was exposed to 254 nm (UV-C) and the other to 365 nm (UV-A) UV. Growth retardation effect of UV was investigated with respect to germination percentage, total weight gain, and root elongation, while cytogenotoxicity arisen from UV exposure was analyzed using mitotic index (MI) and chromosomal aberration (CA) and micronucleus (MN) frequency. Oxidative stress due to UV application was investigated based on the accumulation of malondialdehyde (MDA) and the total activities of superoxide dismutase (SOD) and catalase (CAT) enzymes. Also, anatomical changes induced by UV-A and UV-C were analyzed in root meristematic cells. UV treatments caused significant reductions in growth-related parameters. Both UV treatments caused a significant increase in MDA levels and induction of SOD and CAT enzymes in root meristematic cells. A decrease in MI and an increase in the frequency of MN and CAs were observed in root tip cells, indicating the cytogenotoxic effect of UV application. Anatomical damages such as epidermis cell damage, cortex cell damage, necrotic zones, giant cell nucleus, and indistinct transmission tissue occurred in cells exposed to UV. All of the physiological, biochemical, cytogenetic, and anatomical damages observed in this study were more severe in cells treated with UV-C compared to UV-A. This study suggested that UV exposure triggered growth inhibition, cytogenotoxicity, oxidative stress, and meristematic cell damages in A. cepa roots depending on the wavelength.

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Turmeric (Curcuma longa L.) tends to reduce the toxic effects of nickel (II) chloride in Allium cepa L. roots

Macar

Çavuşoğlu

et al. 2022

Environ Sci Pollut Res

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Extenuating role of lycopene against 254-nm UV-C radiation-mediated damages in Allium cepa L. roots

Cited by 7 publications

References 62 publications

The Prophylactic Effect of Vitamin C and Vitamin B12 against Ultraviolet-C-Induced Hepatotoxicity in Male Rats

The Prophylactic Effect of Vitamin C and Vitamin B12 against Ultraviolet-C-Induced Hepatotoxicity in Male Rats

Comparative investigation of toxicity induced by UV-A and UV-C radiation using Allium test

Turmeric (Curcuma longa L.) tends to reduce the toxic effects of nickel (II) chloride in Allium cepa L. roots

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