Extent of surgery in the management of locally advanced sinonasal malignancies

Resto, Vicente A.; Chan, Annie W.; Deschler, Daniel G.; Lin, Derrick T.

doi:10.1002/hed.20681

Cited by 76 publications

(61 citation statements)

References 19 publications

(29 reference statements)

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“…Data from Massachusetts General Hospital, Harvard Cyclotron Laboratory, Francis Burr Proton Center, USA, are available in the paper of Resto et al [43] From 1991 to 2002, 102 patients with locally advanced sinonasal malignancies of various histology received a mixed photon/proton treatment. Radiotherapy was given as definitive treatment in 32 cases, as adjuvant after partial resection in 50, and as adjuvant after complete resection in 20.…”

Section: Resultsmentioning

confidence: 99%

Sinonasal Malignancies and Charged Particle Radiation Treatment: A Systematic Literature Review

Cianchetti

Amichetti²

2012

International Journal of Otolaryngology

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Background. Paranasal and nasal cavity malignancies are rare tumors that frequently present at advanced stages. Tumor extension and anatomic complexity pose a challenge for their treatment. Due to their peculiar physical and biological properties particle radiation therapy, i.e. protons and ions can have a role in their management. We performed a systematic literature review to gather clinical evidence about their use to treat sinonasal malignancies. Materials and Methods. We searched the browsers PubMed and Medline as well as specific journals and conference proceedings. Inclusion criteria were: at least 10 patients, English language, reporting outcome and/or toxicity data. Results. We found six studies with data on clinical outcome. Carbon and helium ions were each used in one study, protons in four. Toxicity was specifically described in five studies. One reported acute toxicity of carbon ions, one dealt with brain toxicity from both carbon ions and protons. Three papers reported on visual toxicity: one from carbon ions, one from protons and one from both. Specific data were extracted and compared with the most pertinent literature. Conclusion. Particle radiation therapy is in its early phase of development. Promising results achieved so far must be confirmed in further studies.

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Section: Resultsmentioning

confidence: 99%

Sinonasal Malignancies and Charged Particle Radiation Treatment: A Systematic Literature Review

Cianchetti

Amichetti²

2012

International Journal of Otolaryngology

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“…The limited number of reported cases on use of ENI to prevent nodal recurrence further complicates the picture. 12–14, 16 A recently study published by Noh and co-workers, based on 4 patients treated with ENI or neck dissection, showed a 75% rate of cervical failure if no systemic therapies were given. 13 Conversely, earlier studies by University of Florida showed that in 11 patients treated with ENI, none experienced nodal recurrence, whereas 4 of 9 patients who had ENI omitted developed neck failure.…”

Section: Discussionmentioning

confidence: 99%

“…12 Other smaller retrospective studies have also reported conflicting findings after ENI, ranging from no locoregional benefit to significantly improved regional control in clinically N0 patients. 14–16 Given the small number patients of each study and the significant amount of heterogeneity in patient and treatment characteristics, it is difficult to draw a definitive conclusion from the existing literature on the role of ENI in ENB.…”

Section: Discussionmentioning

confidence: 99%

The role of elective nodal irradiation for esthesioneuroblastoma patients with clinically negative neck

Jiang

Mohamed

Fuller

et al. 2016

Practical Radiation Oncology

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Purpose Although adjuvant radiation to the tumor bed has been reported to improve the clinic outcomes of esthesioneuroblastoma (ENB) patients, the role of elective neck irradiation (ENI) in clinically node negative (N0) patients remains controversial. Here, we evaluated the effects of ENI on neck nodal relapse risk in ENB patients treated with radiotherapy as a component of multi-modality treatment. Methods and Materials Seventy-one N0 ENB patients irradiated at XXXXXXXXX between 1970 and 2013 were identified. ENI was performed on 22 of these patients (31%). Survival analysis was performed with focus on comparative outcomes of those patients who did and did not receive ENI. Results The median follow up time for our cohort is 80.8 months (range 6 – 350 month). Among N0 patients, 13 (18.3%) developed neck nodal relapses, with a median time to progression of 62.5 months. None of these 13 patients received prophylactic neck irradiation. ENI was associated with significantly improved regional nodal control at 5-year (regional control rate of 100% for ENI vs 82%, p < 0.001), but not overall survival or disease-free survival. Eleven patients without ENI developed isolated neck recurrences. All had further treatment for their neck disease, including neck dissection (n=10), radiation (n=10), or chemotherapy (n=5). Six of these 11 patients (54.5%) demonstrated no evidence of further recurrence with a median follow up of 55.5 month. Conclusion ENI significantly reduces the risk of cervical nodal recurrence in ENB patients with clinically N0 neck but this did not translate to a survival benefit. Multimodality treatment for isolated neck recurrence provides a reasonable salvage rate. The greatest benefit for ENI appeared to be among younger patients who presented with Kadish C disease. Further studies are needed to confirm these findings.

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“…25,53,55–59 For example, proton therapy was used for locally advanced sinonasal malignancies in 102 patients; disease-free survival rates were 49% to 90% at 5 years, depending on whether patients had partial or complete resection. 60 In comparison, conventional RT with photons has been reported to yield disease-free survival rates of 54% in patients with sinonasal malignancies. 61,62 In an older series, more than 500 patients with chordoma and chondrosarcoma were treated with proton therapy, and relapse-free survival rates were reported to be 73% and 98%, respectively, at 5 years, which is considered to be promising in these challenging disease types.…”

Section: Particle Therapiesmentioning

confidence: 99%

Head and Neck Cancers, Version 1.2015

Pfister

Spencer

Brizel

et al. 2015

J Natl Compr Canc Netw

195

246

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These NCCN Guidelines Insights focus on recent updates to the 2015 NCCN Guidelines for Head and Neck (H&N) Cancers. These Insights describe the different types of particle therapy that may be used to treat H&N cancers, in contrast to traditional radiation therapy (RT) with photons (x-ray). Research is ongoing regarding the different types of particle therapy, including protons and carbon ions, with the goals of reducing the long-term side effects from RT and improving the therapeutic index. For the 2015 update, the NCCN H&N Cancers Panel agreed to delete recommendations for neutron therapy for salivary gland cancers, because of its limited availability, which has decreased over the past 2 decades; the small number of patients in the United States who currently receive this treatment; and concerns that the toxicity of neutron therapy may offset potential disease control advantages.

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Extent of surgery in the management of locally advanced sinonasal malignancies

Cited by 76 publications

References 19 publications

Sinonasal Malignancies and Charged Particle Radiation Treatment: A Systematic Literature Review

Sinonasal Malignancies and Charged Particle Radiation Treatment: A Systematic Literature Review

The role of elective nodal irradiation for esthesioneuroblastoma patients with clinically negative neck

Head and Neck Cancers, Version 1.2015

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