Extensively Drug-Resistant Tuberculosis,Taiwan

Abstract

Extensively Drug-Resistant Tuberculosis, Taiwan

Risk Factors for Poor Treatment Outcomes in Patients With MDR-TB and XDR-TB in China: Retrospective Multicenter Investigation

“…Two reasons might contribute to capreomycin and amikacin, in addition to resistance to isoniazid and rifamplicin, as well as ofloxacin. This is significantly higher than the percentages from other studies [21,28]. In China, the above seven drugs are the most commonly used ones to treat TB and DR-TB.…”

“…In our study, the proportion of all MDR-TB patients with cultures resistant to ofloxacin was up to 69.3% in all MDR-TB patients, and the drug resistant proportion of ofloxacin was 56.8% in Other MDR groups, higher than 6.4%, 16.6% and 42.8% which were respectively reported from Latvia [27], South Korea [10] and Tai Wan [28]. Two reasons might contribute to capreomycin and amikacin, in addition to resistance to isoniazid and rifamplicin, as well as ofloxacin.…”

Impact of resistance to first-line and injectable drugs on treatment outcomes in MDR-TB

“…The median number of drugs to which Mycobacterium tuberculosis isolates were resistant was four (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). A median of six anti-TB drugs (3)(4)(5)(6)(7)(8)(9)(10)(11)(12) were used for a median of 27 (1-136) months. Among the patients, 42 (21.3%) had XDR-TB.…”

“…Among XDR-TB patients with HIV infection, an alarmingly high fatality rate of nearly 100%, with a median survival of only 16 days, was reported [4]. However, XDR-TB has been reported not only among HIV-infected populations, but also among non-HIV-infected patients [5,6]. The current authors recently examined 211 MDR-TB patients without HIV infection in South Korea and reported that the presence of XDR-TB posed 4.46 times higher odds of treatment failure [7].…”

A Reduction in Anti-Tuberculosis Drug Resistance after the Implementation of the National “STOP TB” Program in Central Taiwan, 2003–2007

“…Recently, an outbreak of extensively drugresistant tuberculosis (XDR-TB) was reported in KwaZulu Natal Province in South Africa, and it had a high mortality rate (98z) (4). Untreatable XDR-TB cases have been reported elsewhere, but rarely in Taiwan (5)(6)(7)(8)(9).…”