Extensively drug-resistant community-acquired  Acinetobacter baumannii  sequence type 2 in a dog with urinary tract infection in Thailand

Chanchaithong, Pattrarat; Prapasarakul, Nuvee; Mehl, Nicole Sirisopit; Suanpairintr, Nipattra; Teankum, Komkrich; Collaud, Alexandra; Endimiani, Andrea; Perreten, Vincent

doi:10.1016/j.jgar.2018.02.007

Cited by 5 publications

(13 citation statements)

References 5 publications

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“…A very recent report from the Netherlands described two unrelated ST2 lineages of carbapenem non-resistant A. baumannii as a cause of two outbreaks in a companion animal ICU that occurred in 2012 and 2014. This, together with sporadic findings of carbapenemase-producing ST2- A. baumannii isolates in companion animals in Portugal [ 11 ], Italy [ 25 ], Thailand [ 26 ] and Pakistan [ 28 ], underlines that, with ST2, ST1 and ST25, three of the most relevant sequence types globally distributed in the human domain are also disseminated among companion animals. In a recent study from Germany, Schleicher et al demonstrated that the population structure of carbapenem-susceptible A. baumannii from humans is highly diverse, whereas imipenem non-susceptibility was strongly linked with the clonal lineages IC2 and IC1, suggesting a high clonality of carbapenem-resistant isolates [ 44 ].…”

Section: Discussionmentioning

confidence: 95%

“…In contrast, none of the A. baumannii isolates from livestock animals ( n = 50 isolates), horses ( n = 46), small animals ( n = 15), and other animals ( n = 10) harboured a carbapenemase. To date, to the best of our knowledge, merely 12 studies described the occurrence of CPs, predominantly OXA-23, but also OXA-72 and NDM-1, in Acinetobacter baumannii from cats and dogs in Germany, France, Portugal, Italy, Serbia, Pakistan and Thailand [ 8 , 9 , 10 , 11 , 12 , 13 , 19 , 25 , 26 , 27 , 28 ] ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

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Genomic Analysis of Acinetobacter baumannii Isolates Carrying OXA-23 and OXA-58 Genes from Animals Reveals ST1 and ST25 as Major Clonal Lineages

Jacobmeyer

Semmler

Stamm³

et al. 2022

Antibiotics

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Acinetobacter baumannii is increasingly being recognized as a relevant pathogen for animals with a putative zoonotic impact. This study aimed at identifying and characterizing carbapenemase-producing A. baumannii from animals. Among 503 A. baumannii, mainly isolated from dogs/cats (75.7%) between 2013 and 2018, 42 isolates from 22 veterinary clinics (VCs) harboured blaOXA-58 (n = 29) or blaOXA-23 (n = 13). The blaOXA-58 gene was located on plasmids (11.4–21.1 kb) within different genetic surroundings (patterns A–D). BlaOXA-23 was embedded in Tn2006 on the chromosome (n = 4; pattern a) or Tn2008 on plasmids (n = 9; 41.2–71.3 kb; patterns b–e). The predominant IC1-ST1P-OXA-58 (66.7%; 96.4% cgMLST complex type (CT)-1808) was disseminated among 11 VCs in Germany. Resistance islands AbaR3-like (n = 15) and AbaR10 (n = 1) have emerged among ST1-isolates since 2016. IC7-ST25P-OXA-23 isolates (21.4%) occurred in seven VCs in Germany, France and Italy and differed in their resistance gene patterns from those of OXA-58 isolates. They were separated into six CTs, basically according to their regional origin. Other STs observed were ST10, ST578 and ST602. In conclusion, OXA-23 and OXA-58 were linked with ST1 and ST25, two globally distributed lineages in humans. The suggested transmission of certain lineages within and among VCs together with the acquisition of AbaR islands hints at a successful dissemination of multidrug-resistant strains in the VC environment.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Genomic Analysis of Acinetobacter baumannii Isolates Carrying OXA-23 and OXA-58 Genes from Animals Reveals ST1 and ST25 as Major Clonal Lineages

Jacobmeyer

Semmler

Stamm³

et al. 2022

Antibiotics

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“…In two cases of UTI in a cat from Portugal and a dog from Thailand, OXA-23-producing ST2 A. baumannii was identified. A. baumannii ST2 producing OXA-23 were also reported in these countries in humans indicating that such clones may be adapted to both humans and animals representing a zoonotic lineage and possible community-acquisition [39,81). Another study revealed a possible endemicity of OXA-23-producing ST25 A. baumannii from urinary tract infections in cats and dogs in France, but the epidemiology appeared to be independent of that of humans since ST25 A. baumannii from humans in this country mostly harbored OXA-58 [5,82].…”

Section: Zoonotical Aspectsmentioning

confidence: 99%

“…The isolates belonged to two main clonal lineages (as determined by rep-PCR and MLST) which were related to sequence types of IC I and II also of importance in human medicine. Of concern is the emergence of OXA-23 carbapenemase production in genetically diverse A. baumannii from dogs with UTI in France and Thailand, and from vaginal and phlegmon samples from dogs in Germany (Table 2) [5,81,[89][90][91]. The two isolates from Germany belonged to ST10 (IC8) with the blaOXA-23 located on Tn2008 (89), whereas the two French isolates belonged to ST25 with the blaOXA-23 also located on Tn2008B.…”

Section: Dogmentioning

confidence: 99%

Acinetobacter in veterinary medicine, with an emphasis on Acinetobacter baumannii

Kolk

Endimiani

Graubner

et al. 2019

Journal of Global Antimicrobial Resistance

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Acinetobacter spp. are aerobic, rod-shaped Gram-negative bacteria belonging to the Moraxellaceae family of the class Gammaproteobacteria and are considered ubiquitous organisms. Among them, Acinetobacter baumannii is the most clinically significant species with an extraordinary ability to accumulate antimicrobial resistance and survive in the hospital environment. Recent reports indicate that A. baumannii has also evolved into a veterinary nosocomial pathogen. Although Acinetobacter spp. can be identified to species level by the use of the matrix-assisted laser ionization time-of-flight mass spectrometry (MALDI-TOF MS) coupled with an updated database, molecular techniques are still necessary for genotyping and determination of clonal lineages. It seems that the majority of infections due to A. baumannii in veterinary medicine are nosocomial. Such isolates have been associated with several type of infections such as canine pyoderma, feline necrotizing fasciitis, urinary tract infections, equine thrombophlebitis and lower respiratory tract infections, foal sepsis, pneumonia in mink and cutaneous lesions in hybrid falcon. Given the potential multidrug resistance of A. baumannii, treatment of diseased animals is often supportive and should be based preferably on in vitro antimicrobial susceptibility testing. It should be noted that animal isolates show a high genetic diversity and are in general distinct in their sequence types and resistance patterns from those found in humans. However, it cannot be excluded that animals may occasionally play a role as reservoir for A. baumannii. In line, it is of importance to implement infection control measures in veterinary hospitals to avoid nosocomial outbreaks with multidrug-resistant A. baumannii.

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“…Enterococci, in particular Enterococcus faecalis and Enterococcus faecium , but also the Gram-negative species Escherichia coli , Pseudomonas aeruginosa , and Acinetobacter baumannii have zoonotic potential. All of them cause infections in companion animals, especially skin, ear, or urinary tract infections [ 12 , 13 , 14 , 15 , 16 , 17 ]. In human medicine, some of these species, including E. faecium , P. aeruginosa , and A. baumannii , are among the so-called ESKAPE pathogens (which in addition to the aforementioned three pathogens also include Staphylococcus aureus , Klebsiella pneumoniae , and Enterobacter spp.)…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Biocide Resistance among Canine and Feline Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii Isolates from Diagnostic Submissions

et al. 2022

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A total of 215 isolates from infections of dogs and cats, including 49 Enterococcus faecalis, 37 Enterococcus faecium, 59 Escherichia coli, 56 Pseudomonas aeruginosa, and 14 Acinetobacter baumannii, were investigated for their susceptibility to 27 (Gram-positive bacteria) or 20 (Gram-negative bacteria) antimicrobial agents/combinations of antimicrobial agents by broth microdilution according to the recommendations of the Clinical and Laboratory Standards Institute. Moreover, all isolates were analysed for their susceptibility to the biocides benzalkonium chloride, chlorhexidine, polyhexanide, and octenidine by a recently published broth microdilution biocide susceptibility testing method. While the E. faecalis isolates did not show expanded resistances, considerable numbers of the E. faecium isolates were resistant to penicillins, macrolides, tetracyclines, and fluoroquinolones. Even a single vancomycin-resistant isolate that carried the vanA gene cluster was detected. Expanded multiresistance phenotypes were also detected among the E. coli isolates, including a single carbapenem-resistant, blaOXA-48-positive isolate. In addition, multiresistant A. baumannii isolates were detected. The minimal inhibitory concentrations of the biocides showed unimodal distributions but differed with respect to the biocide and the bacterial species investigated. Although there were no indications of a development of biocide resistance, some P. aeruginosa isolates exhibited benzalkonium MICs higher than the highest test concentration.

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Extensively drug-resistant community-acquired Acinetobacter baumannii sequence type 2 in a dog with urinary tract infection in Thailand

Cited by 5 publications

References 5 publications

Genomic Analysis of Acinetobacter baumannii Isolates Carrying OXA-23 and OXA-58 Genes from Animals Reveals ST1 and ST25 as Major Clonal Lineages

Genomic Analysis of Acinetobacter baumannii Isolates Carrying OXA-23 and OXA-58 Genes from Animals Reveals ST1 and ST25 as Major Clonal Lineages

Acinetobacter in veterinary medicine, with an emphasis on Acinetobacter baumannii

Antimicrobial and Biocide Resistance among Canine and Feline Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii Isolates from Diagnostic Submissions

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