Extensive Tubular Secretion and Reabsorption of Creatinine in Humans

Sjöström, Per; Odlind, Bo; Wolgast, M.

doi:10.1080/00365599.1988.11690398

Cited by 49 publications

(32 citation statements)

References 14 publications

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“…A large increase in the excreted fraction of creatinine has been reported following hydration, probably owing to an increased secretion and decreased reabsorption of creatinine (16). Another consequence of the large urinary volumes is probably a more variable CLCR (Fig.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of foscarnet and distribution to cerebrospinal fluid after intravenous infusion in patients with human immunodeficiency virus infection

Sjövall

Bergdahl

Movin

et al. 1989

Antimicrob Agents Chemother

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To investigate the pharmacokinetics and effects of intravenous foscarnet, 13 relatively healthy male patients with human immunodeficiency virus infection and a mean CD4+ lymphocyte value of 0.45 x 10-9 cells per liter were given a continuous intravenous infusion of foscarnet (0.14 to 0.19 mg/kg per min) for 8 to 21 days. Blood and urine samples were taken during and after drug administration to monitor foscarnet concentrations. Lumbar puncture was performed during the infusion in five patients. The concentrations in plasma showed large variations both within and between patients. The disposition of foscarnet could be explained by a triexponential equation (tl2,1, 0.40 to 2.52 h; t112X, 3.20 to 16.7 h; tl/2J3, 36 to 196 h). Renal clearance accounted for most of the plasma clearance, the dilerence probably reflecting the passage of foscarnet into bone. Up to 20% of the cumulative dose may have been deposited in bone 7 days postinfusion. Foscarnet was distributed to the cerebrospinal fluid in a concentration varying from 13 to 68% of the simultaneous concentration in plasma. Polyuria and polydipsia were recorded in all patients. There appears to be an association between the degree of malaise, including symptoms such as nausea, vomiting, fatigue, and headache, and concentrations in plasma above 350 ,umol/liter.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of foscarnet and distribution to cerebrospinal fluid after intravenous infusion in patients with human immunodeficiency virus infection

Sjövall

Bergdahl

Movin

et al. 1989

Antimicrob Agents Chemother

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“…3 equationshave been considered the most acceptable creatinine-basedequations for estimating GFR.However, there are a number of disadvantages in using serumcreatinine itself as afiltration marker 6,7 . Therefore, identifying a new endogenous filtration marker is necessary for theaccurate and convenient estimation of GFR.…”

Section: Discussionmentioning

confidence: 99%

“…Among these equations, the Modification of Diet in Renal Disease (MDRD) 3 , Cockcroft-Gault 4 and Chronic Kidney Disease Epidemiology collaboration (CKD-EPI) 5 have been accepted for creatinine based equations to estimate the GFR. However, there are a number of disadvantages in using serum creatinine itself as a filtration marker 6,7 . Hence, identifying an alternative filtration marker is vital for accurate, reproducible and unbiased estimation of GFR.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Chronic Kidney Disease Epidemiology Collaboration Equations with Other Accepted Equations for Estimation of Glomerular Filtration Rate in Indian Chronic Kidney Disease Patients

Ramanathan

Padmanabhan²

2017

Bangladesh J Med Sci

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Background and Aim:In routine clinical practice, the estimation of glomerular filtration rate (GFR) based on serum creatinine has been followed. However, the reliability of creatinine in estimation of GFR is biased and imprecise, leading to the misdiagnosis of chronic kidney disease (CKD). The serum cystatin C is an alternative marker for estimating GFR. Hence, we aimed to compare the newly proposed Chronic Kidney Disease Epidemiology Collaboration Equations (CKD-EPI) with four approved equations based on both creatinine and cystatin C with reference to Tc-99m-diethylenetriamine pentaacetate (Tc-99m-DTPA) considered as a standard. Materials and Methods:Two hundred and one patients were enrolled in the study from a private nephrology outpatient clinic(OPD), Tiruchirappalli, India. The serum creatinine and cystatin C were measured along with routine biochemistry tests. The measurement of GFR was done by Tc-99m-DTPA gates method. The estimated GFR (eGFR) were calculated using serum cystatin C and creatinine based formulae along with the new CKD-EPI formulae. All eGFR estimations were compared with the measured GFR by gates method. Results: The average measured GFR of end stage, severe, moderate, mild renal disease and normal patient groups were 10.17±2.47, 22.58±4.40, 39.05±7.06, 69.62±24.64 and 118.06±29.23 respectively. When comparing the diagnostic accuracy for predicting GFR using well established formulae, the cystatin C based formulae have shown to be highly accurate in all stages of CKD than creatinine based formulae. Among cystatin C based formulae, CKD-EPI Cystatin C had relatively better diagnostic accuracy for predicting GFR in all stages of CKD. Conclusion: CKD-EPI Cystatin C formula has unbiased and more accurate to predict GFR in all stages of CKD.

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“…Estimation of GFR can be done using Modification of Diet in Renal Disease (MDRD), abbreviated MDRD, or Cockcroft and Gault (C-G) equations (5), which can present different results. Differences in results are due to the standardization of analytical techniques, the rate of production and tubular secretion of creatinine (6).…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Estimated GFRs Based on Formulas of Serum Cystatin C and Serum Creatinine

Mousavinasab

Jalalzadeh

2017

Nephrourol Mon

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Background: Serum cystatin C has been identified as a marker for the estimation of glomerular filtration rate (GFR). Although this marker is more sensitive than creatinine, it is too expensive and not available in all laboratories. In this study, we compared cystatin C-based equations with creatinine-based formulas to select the most precise creatinine-based formula for estimating GFR in patients with chronic kidney disease (CKD).

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Extensive Tubular Secretion and Reabsorption of Creatinine in Humans

Cited by 49 publications

References 14 publications

Pharmacokinetics of foscarnet and distribution to cerebrospinal fluid after intravenous infusion in patients with human immunodeficiency virus infection

Pharmacokinetics of foscarnet and distribution to cerebrospinal fluid after intravenous infusion in patients with human immunodeficiency virus infection

Comparison of Chronic Kidney Disease Epidemiology Collaboration Equations with Other Accepted Equations for Estimation of Glomerular Filtration Rate in Indian Chronic Kidney Disease Patients

A Comparison of Estimated GFRs Based on Formulas of Serum Cystatin C and Serum Creatinine

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