Extensive Transmission of Mycobacterium Tuberculosis from a 9-Year Old Child with Sputum - Smear-Negative Pulmonary Tuberculosis

Paranjothy, Shantini; Eisenhutt, M.; Lilley, M; Bracebridge, Sam; Abubakar, Ibrahim; Mulla, Rohinton; Lack, K.; Chalkley, D.; Howard, Julia; Thomas, Sandra H.; McEvoy, M

doi:10.1016/j.ijid.2008.05.014

Cited by 5 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is lower than a study in England where the infection rate in the class of the smear-negative index case was 79% and was 35% for other students in the school [7]. Furthermore, 3 (5.7%) cases of active TB were identified.…”

Section: Discussioncontrasting

confidence: 61%

“…This study is one of the very few [7] to document the transmission of TB from a smear-negative child.…”

Section: Discussionmentioning

confidence: 99%

“…Early case detection and diagnosis of TB and supervised treatment are vital for control and reduction of TB and are part of the components of the Stop TB strategy [4]]. Thus, many studies have highlighted the importance of tracing the contacts of an adult smear-positive case [5,6] but a few have investigated the contacts of a smearnegative child as an index case [7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Contact tracing of a 15-year-old girl with smearnegative pulmonary tuberculosis in Tehran

Baghaie¹,

Khalilzadeh²,

Mr³

et al. 2012

East Mediterr Health J

View full text Add to dashboard Cite

Early detection of tuberculosis (TB) cases and supervised treatment are vital for control of the disease. To assess TB transmission from a sputum smear-negative pulmonary TB case, the contacts of a 15-year-old Iranian girl diagnosed with smear-negative TB in 2010 were traced. In all, 52 classmates and close friends and 15 school staff were screened by tuberculin skin test and chest X-ray. Those with a positive skin test or abnormal chest X-ray were further evaluated by chest spiral computed tomography (CT) scan and triple gastric washing. All classmates and close friends were Iranian and female. Of the 52 girls, 17 (32%) had latent infection (either positive skin test or abnormal chest X-ray) and 3 (5.7%) had active TB (abnormal CT or positive culture additional to positive skin test or abnormal X-ray). None of the staff had abnormal findings. Contact tracing should be considered for contacts of all children with symptomatic pulmonary TB, even those who are smear-negative.

show abstract

Section: Discussioncontrasting

confidence: 61%

“…This study is one of the very few [7] to document the transmission of TB from a smear-negative child.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Contact tracing of a 15-year-old girl with smearnegative pulmonary tuberculosis in Tehran

Baghaie¹,

Khalilzadeh²,

Mr³

et al. 2012

East Mediterr Health J

View full text Add to dashboard Cite

show abstract

“…Public health authorities should ensure that the media receive and disseminate correct information. If the index case is a pupil and the source of infection unknown, a source investigation as well as a contact investigation may be necessary (C) [248].…”

Section: Schoolsmentioning

confidence: 99%

Tuberculosis contact investigation in low prevalence countries: a European consensus

Erkens

Kamphorst²,

Abubakar

et al. 2010

European Respiratory Journal

Self Cite

234

201

View full text Add to dashboard Cite

Contact investigation to identify individuals with tuberculosis and latent infection with Mycobacterium tuberculosis is an important component of tuberculosis control in low tuberculosis incidence countries. This document provides evidence-based and best-practice policy recommendations for contact tracing among high-and medium-priority contacts in a variety of settings. It provides a basis for national guidelines on contact investigation and tuberculosis outbreak management, and should support countries and tuberculosis control managers in evaluating and revising national policies. A review of existing guidelines, a literature search, several meetings and consultation with experts were used to formulate and grade recommendations for action during contact investigation.Available tests to identify individuals with latent infection with M. tuberculosis are designed to identify immune response against mycobacterial antigens and have variable predictive value for the likelihood to develop active tuberculosis in different populations. Contact investigation should therefore be limited to situations with a clear likelihood of transmission or to those with a higher probability of developing active tuberculosis, for instance, young children and immunocompromised persons. A risk assessment-based approach is recommended, where the need to screen contacts is prioritised on the basis of the infectiousness of the index case, intensity of exposure and susceptibility of contacts.

show abstract

“…DNA fingerprinting has contributed significantly to the understanding of the epidemiology and control of TB by providing information on transmission dynamics (19,21,38), determining the importance of reactivation versus exogenous reinfection (10,34), investigating/confirming outbreaks (29), and confirmation of laboratory cross contamination (2). The most widely applied and current standard method for comparing the genetic relatedness of M. tuberculosis strains is IS6110-based restriction fragment length polymorphism (RFLP) (41).…”

mentioning

confidence: 99%

Genetic Diversity of Mycobacterium tuberculosis Isolates from a Tertiary Care Tuberculosis Hospital in South Korea

et al. 2010

View full text Add to dashboard Cite

960, 1955, 2163b, 2165, 2996, 3192, 4052, and 4348) (h ‫؍‬ 0.98) that was able to differentiate most of the closely related strains was identified. These findings suggest that 24-locus-based MIRU-VNTR typing is a likely suitable alternative to RFLP to differentiate clinical isolates in this setting, which is dominated by M. tuberculosis Beijing strains. Within the study limits, our results also suggest that the problem of drug-resistant TB in the Republic of Korea may be largely due to acquired resistance as opposed to transmission.

show abstract

Extensive Transmission of Mycobacterium Tuberculosis from a 9-Year Old Child with Sputum - Smear-Negative Pulmonary Tuberculosis

Cited by 5 publications

References 0 publications

Contact tracing of a 15-year-old girl with smearnegative pulmonary tuberculosis in Tehran

Contact tracing of a 15-year-old girl with smearnegative pulmonary tuberculosis in Tehran

Tuberculosis contact investigation in low prevalence countries: a European consensus

Genetic Diversity of Mycobacterium tuberculosis Isolates from a Tertiary Care Tuberculosis Hospital in South Korea

Contact Info

Product

Resources

About