Extensive target cell loss during development results in mossy fibers in the regio superior (CA1) of the rat hippocampal formation

Cook, T. M.; Crutcher, Keith A.

doi:10.1016/0165-3806(85)90020-3

Cited by 23 publications

(5 citation statements)

References 46 publications

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“…At the same time, its absence in the infrapyramidal mossy fiber tract became evident. Thus the appearance of neurocan in the layers surrounding the mossy fiber tract is intimately correlated with the development of the mossy fiber tract (Amaral and Dent 1981;Cook and Crutcher 1985;Gaarskjaer 1985;Seki and Rutishauser 1998). Neurocan is generally reported to have an inhibitory action against neurite extension or regeneration (Kato-Semba et al 1998;Asher et al 2000;Wilson and Snow 2000).…”

Section: Discussionmentioning

confidence: 97%

“…The dentate granule cell layer was formed by the end of the first postnatal week (Schlessinger et al 1975;Altman and Bayer 1990). Most mossy fibers synapse on CA3 pyramidal neurons on P3-P5 (Cook and Crutcher 1985) and reach their mature configuration on P12-P15 (Amaral and Dent 1981;Gaarskjaer 1985;Seki and Rutishauser 1998). Initially, only suprapyramidal mossy fibers are observed.…”

Section: Discussionmentioning

confidence: 98%

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Developmentally regulated expression of brain-specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the postnatal rat hippocampus

Okamoto

Sakiyama

Kurazono

et al. 2001

Cell and Tissue Research

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Developmental changes in the distribution of brain-specific chondroitin sulfate proteoglycans, neurocan and phosphacan/RPTPzeta/beta, in the hippocampus of the Sprague-Dawley rat were examined using monoclonal antibodies 1G2 and 6B4. The 1G2 immunoreactivity was predominant in the neonatal hippocampus while the 6B4 immunoreactivity was predominant in the mature hippocampus. Moderate 1G2 immunoreactivity was detected in the dentate gyrus and subiculum immediately after birth. Immunoreactivity reached a peak on postnatal days 7-10 (P7-P10) when intense 1G2 labeling was present throughout the neuropil layers of the hippocampus except the mossy fiber tract. 6B4 immunoreactivity was limited in the stratum lacunosum moleculare of CA1 in the neonatal hippocampus. It gradually increased by P21 when diffuse 6B4 immunoreactivity was detected in the stratum oriens and radiatum of Ammon's horn, and in the hilus and inner one-third molecular layer of the dentate gyrus, while 1G2 immunoreactivity decreased after P21. In the adult hippocampus, moderate 6B4 immunoreactivity was present in the stratum oriens and radiatum of Ammon's horn, and in the hilus and inner one-third molecular layer of the dentate gyrus, but not in the mossy fiber tract. In addition, strong 6B4 labeling appeared around a subset of neurons after P21. The results suggest that neurocan may have a role in the development of neuronal organization, while phosphacan/RPTPzeta/beta may contribute to the maintenance and plasticity of synaptic structure and function. Furthermore, the absence of 1G2 and 6B4 immunoreactivities in the stratum lucidum suggests that neurocan and phosphacan/RPTPzeta/beta may function as a barrier for the extension of mossy fibers and provide an environment permissive for fasciculation of the mossy fibers.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Developmentally regulated expression of brain-specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the postnatal rat hippocampus

Okamoto

Sakiyama

Kurazono

et al. 2001

Cell and Tissue Research

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“…Regardless of their phylogenetic position, hedgehogs provide a unique opportunity to examine morphology and function in a species that has apparently changed very little since it appeared in the Eocene period. Of particular interest to compara tive neurobiologists is the rather surprising discovery that the hippocampal region in hedgehogs exhibits a consistent unique feature, namely the extension of dentate granule cell axons (mossy fibers) into the regio superior of the hippocampus [14], The reason for this variation is unclear, but since a similar innerva tion pattern can be obtained in rats during develop ment, it has been suggested that this represents an an cestral pattern of connectivity [5]. If so, the more res tricted distribution of mossy fibers in other species may be the result of selective pressures resulting in a topography of mossy fibers that is advantageous in some way.…”

Section: Discussionmentioning

confidence: 99%

Hippocampus and Dentate Area of the European Hedgehog

1988

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The hippocampal formation in the European hedgehog was examined with acetylcholinesterase (AChE) histochemistry and catecholamine histofluorescence in order to define the normal distribution of septohippocampal fibers and noradrenergic fibers, respectively, as well as to compare these inputs with the hippocampal cytoarchitecture as revealed with Nissl stain. In addition, alterations in the histochemical appearance following septohippocampal denervation were examined. Although the overall pattern of AChE-positive and noradrenergic fibers is similar to that observed in other mammals, some striking variations were observed, particularly within the dentate area. Thus, except for a heavily stained supragranular band, the AChE activity of the molecular layer is uniformly low without any obvious lamination, contrasting with the situation in most other mammalian species. The noradrenergic innervation of the dentate area showed the same density of fibers in the molecular layer and hilus, a pattern differing strikingly from the predominance of noradrenergic fibers in the hilus of other mammalian species. Such variations may reflect greater phylogenetic diversity in diffuse modulatory connections as compared with more precise topographical pathways.

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“…SE does not result in neuronal cell death (Nitecka et al, 1984; Hirsch et al, 1992; Priel et al, 1996; Toth et al, 1998; Cilio et al, 2003; Dube et al, 2004), the reasons for which seem multifactorial (reviewed in Wasterlain et al, 2002; Haut et al, 2004). Mossy‐fiber sprouting usually does not occur in the hippocampus following SE (Priel et al, 1996; Yang et al, 1998), although the immature dentate gyrus is capable of mossy‐fiber sprouting in response to injury at this age (Laurberg and Zimmer, 1980; Cook and Crutcher, 1985). In contrast to this general trend, experimental febrile SE in the normal P10 rat has been shown to result in SRS in 35% of animals (Dube et al, 2006).…”

Section: Early Postnatal Rats (P0‐10)mentioning

confidence: 99%

Age‐Dependent Consequences of Status Epilepticus: Animal Models

et al. 2007

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Summary:Status epilepticus (SE) is a significant neurological emergency that occurs most commonly in children. Although SE has been associated with an elevated risk of brain injury, it is unclear from clinical studies in whom and under what circumstances brain injury will occur. The purpose of this review is to evaluate the effects of age on the consequences of SE. In this review, we focus mainly on the animal data that describe the consequences of a single episode of SE induced in the adult and immature rat brain. The experimental data suggest that the risk of developing SE-induced brain damage, subsequent epilepsy and cognitive deficits in large part depends on the age in which the SE occurs. Younger rats are more resistant to seizure-induced brain damage than older rats; however, when SE occurs in immature rats with abnormal brains, there is an increase in the severity of seizure-induced brain injury. Better understanding of the pathophysiologic mechanisms underlying the age-specific alterations to the brain induced by SE will lead to the development of novel and effective strategies to improve the deleterious consequences.

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Extensive target cell loss during development results in mossy fibers in the regio superior (CA1) of the rat hippocampal formation

Cited by 23 publications

References 46 publications

Developmentally regulated expression of brain-specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the postnatal rat hippocampus

Developmentally regulated expression of brain-specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the postnatal rat hippocampus

Hippocampus and Dentate Area of the European Hedgehog

Age‐Dependent Consequences of Status Epilepticus: Animal Models

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