Extensive retraction artefact predicts biochemical recurrence‐free survival in prostatic carcinoma

Tomas, Davor; Spajić, Borislav; Milošević, Milan; Demirović, Alma; Marušić, Zlatko; Krušlin, Božo

doi:10.1111/j.1365-2559.2011.03769.x

Cited by 15 publications

(15 citation statements)

References 21 publications

(112 reference statements)

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“…Stromal reaction (or desmoplasia), which occurs in most solid human cancers50, contains increased number of fibroblast and myofibroblasts and modifies extracellular matrix composition. We also found that the discriminating features are frequently present next to periacinar retraction (clefting), a separation of the gland from the adjacent stroma that has been associated with cancer recurrence51.…”

Section: Resultsmentioning

confidence: 67%

Improving Prediction of Prostate Cancer Recurrence using Chemical Imaging

Kwak

Kajdacsy-Balla

Macias

et al. 2015

Sci Rep

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Precise Outcome prediction is crucial to providing optimal cancer care across the spectrum of solid cancers. Clinically-useful tools to predict risk of adverse events (metastases, recurrence), however, remain deficient. Here, we report an approach to predict the risk of prostate cancer recurrence, at the time of initial diagnosis, using a combination of emerging chemical imaging, a diagnostic protocol that focuses simultaneously on the tumor and its microenvironment, and data analysis of frequent patterns in molecular expression. Fourier transform infrared (FT-IR) spectroscopic imaging was employed to record the structure and molecular content from tumors prostatectomy. We analyzed data from a patient cohort that is mid-grade dominant – which is the largest cohort of patients in the modern era and in whom prognostic methods are largely ineffective. Our approach outperforms the two widely used tools, Kattan nomogram and CAPRA-S score in a head-to-head comparison for predicting risk of recurrence. Importantly, the approach provides a histologic basis to the prediction that identifies chemical and morphologic features in the tumor microenvironment that is independent of conventional clinical information, opening the door to similar advances in other solid tumors.

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Section: Resultsmentioning

confidence: 67%

Improving Prediction of Prostate Cancer Recurrence using Chemical Imaging

Kwak

Kajdacsy-Balla

Macias

et al. 2015

Sci Rep

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“…In our previous study, we examined whether extensive retractions could predict biochemical reccurence-free survival in prostatic carcinoma. The extent of retraction showed a statistically significant positive correlation with preoperative PSA and negative correlation with biochemical disease free survival [15]. Also, tumors associated with seminal vesicle invasion and/or extracapsular extension showed significantly higher percentage of retraction artifact than tumors without these features [15].…”

Section: Discussionmentioning

confidence: 98%

“…Some authors suggest that the presence and extent of clefts around tumorous tissue, not only in prostatic adenocarcinoma but also in some other tumors, especially breast carcinoma, can predict nodal metastasis and patients' outcome [12][13][14]. Moreover, the presence of extensive retraction clefting in prostatic carcinoma is associated with more aggressive tumor phenotype and a shorter biochemical recurrence-free interval [15].…”

Section: Introductionmentioning

confidence: 99%

Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma

Ulamec

Džombeta

Čupić

et al. 2011

Pathol. Oncol. Res.

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Retraction clefting is known to appear in various types of tumors, but it has only recently been recognized as a specific histological phenomenon. Previously, it was considered merely a laboratory procedure artifact, but lately, there have been some assumptions that peritumoral retractions actually represent lymphatic spaces. In our study, we analyzed neoplastic glands in 52 specimens of prostatic adenocarcinoma. Immunohistochemical analysis was performed using D2-40 antibody, to highlight lymphatic endothelium and thereby differentiate actual lymph vessels or lymphovascular invasion from periacinar retractions. Our results showed that the number of lymph vessels was significantly lower in tumorous tissue compared to adjacent normal prostatic tissue. On the other hand, the number of lymph vessels in tumorous tissue was significantly higher than the number of lymph vessels mimicking periacinar retractions. Overall, the number of lymph vessels mimicking periacinar clefts was particularly low. These results are in accordance with our previous studies, which had shown that periacinar clefting appears due to lack of basal cells and stromal changes around tumorous acini. Also, these results support our hypothesis that retractions do not represent lymph vessels but should be considered a distinct entity, which is proven to be helpful both as diagnostic and predictive factor.

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“…Furthermore, periacinar retraction artifact was also proposed as an additional and helpful diagnostic criterion in breast and urothelial carcinoma [40,41]. In addition, recent results revealed that the retraction artefact in prostatic carcinoma correlates with different clinicopathological features of the tumor as well as with the biochemical recurrence-free survival, pointing out that the presence and the extent of the retraction artifact could predict worse outcome in patients with prostatic adenocarcinoma [42]. The similar prognostic significance of retraction artifact has been reported in breast carcinoma [43,44].…”

Section: Fibroblasts and Myofibroblastsmentioning

confidence: 99%

Prostate cancer stroma: an important factor in cancer growth and progression

2015

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Reactive stromal changes that occur in different human cancers might play a role in local tumor spreading and progression. Studies done on various human cancers have shown activated stromal cell phenotypes, modified extracellular matrix (ECM) composition, and increased microvessel density. Furthermore, they exhibit biological markers consistent with stroma at the site of wound repair. In prostate cancer, stroma is composed of fibroblasts, myofibroblasts, endothelial cells and immune cells. Predominant cells in the tumorous stroma are, however, fibroblasts/myofibroblasts. They are responsible for the synthesis, deposition and remodeling of the ECM. Epithelial tumorous cells, in interaction with stromal cells and with the help of various molecules of ECM, create a microenvironment suitable for cancer cell proliferation, movement, and differentiation. In this review, we discussed the role of different stromal components in prostate cancer as well as their potential prognostic and therapeutic significance.

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Extensive retraction artefact predicts biochemical recurrence‐free survival in prostatic carcinoma

Abstract: The presence of extensive retraction artefact in prostatic carcinoma correlates with tumour characteristics signifying aggressive behaviour and indicates poor biochemical recurrence-free survival.

Cited by 15 publications

References 21 publications

Improving Prediction of Prostate Cancer Recurrence using Chemical Imaging

Improving Prediction of Prostate Cancer Recurrence using Chemical Imaging

Periacinar Retraction Clefting and D2-40 Expression in Prostatic Adenocarcinoma

Prostate cancer stroma: an important factor in cancer growth and progression

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