Extensive preclinical investigation of polymersomal formulation of doxorubicin versus Doxil-mimic formulation

Alibolandi, Mona; Abnous, Khalil; Mohammadi, Marzieh; Hadizadeh, Farzin; Sadeghi, Fatemeh; Taghavi, Sahar; Jaafari, Mahmoud Reza; Ramezani, Mohammad

doi:10.1016/j.jconrel.2017.08.030

Cited by 62 publications

(31 citation statements)

References 34 publications

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“…Furthermore, the toxic effects of irinotecan, CS-PLGA-SN38, tetrac-CS-PLGA-SN38 and blank tetrac-CS-PLGA were evaluated through determination of mice body weight and survival rates which were measured for 35 days after the tumour initiation or it was interrupted if one of the following conditions was met: (i) the mouse lost more than 80% of the body weight; (ii) the tumour diameter became larger than 2 cm; (iii) they became ill and unable to feed; or (iv) they were found dead [5,6].…”

Section: In Vivo Antitumour Activitymentioning

confidence: 99%

“…One of the attractive approaches to minimize the accumulation of chemotherapeutics in non-target organs is to benefit from targeted delivery systems using homing agents such as folic acid [2,3], transferrin [4], small chemical molecules [5], aptamers [6] and peptides [7]. Despite many promising findings reporting the efficient uptake and activity of simple targeted delivery systems, the extravasation of targeted agents from tumour vasculature to the parenchyma is still the ratelimiting stage for specific drug delivery [8].…”

Section: Introductionmentioning

confidence: 99%

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Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38

Alibolandi

Farzad

Mohammadi

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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New integrin-targeted nanoparticles made of chitosan-stabilized PLGA matrix was developed to specifically target colon adenocarcinoma. To this aim, SN38-encapsulated chitosan-coated PLGA NPs were conjugated with tetrac for integrin receptor-guided delivery. To provide a sustained release pattern for SN38, it was loaded into nanoparticles using single emulsion method. The size of NPs were 174.23 ± 6.12 nm with drug encapsulation efficiency and loading content of 73.16 ± 11.15 and 4.45 ± 0.31, respectively. The in vitro results confirmed that the designed nanoplatform showed specific cellular uptake and cytotoxicity in integrin overexpressing cancer cells and provided a sustained release profile for SN38. Additionally, an increased therapeutic potency of targeted formulation over both non-targeted and free drug was shown in vivo.

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Section: In Vivo Antitumour Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38

Alibolandi

Farzad

Mohammadi

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…Liposomes are synthetic spherical vesicles made of lipid bilayers, and Doxil, which is the first FDA‐approved nanomedicine, is made of nanoliposomes encapsulating doxorubicin as an anticancer agent . The use of liposomal doxorubicin alters the pharmacokinetics of free doxorubicin and leads to an accumulation of the drug in tumor tissue, enhancing therapeutic efficacy while reducing the toxicity associated with high doses .…”

Section: Introduction (Vesicular Systems and Why Hybrid Ones?)mentioning

confidence: 99%

“…Studies have demonstrated that the poor release rate of the active drug and lower cellular uptake in the tumor microenvironment are the main challenges facing the Doxil formulation. [2a,7]…”

Section: Introduction (Vesicular Systems and Why Hybrid Ones?)mentioning

confidence: 99%

Hybrid Vesicular Drug Delivery Systems for Cancer Therapeutics

Mohammadi

Taghavi

Abnous

et al. 2018

Adv Funct Materials

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Nanoscale vesicles have provided a versatile platform for the transportation of various types of anticancer and diagnostic agents. Vesicular carriers comprised of liposomes, polymersomes, and peptide-based vesicles have exhibited potential characteristics for nanomedicine developments. However, the represented systems and current therapeutic approaches to cancers are confronted with serious limitations that hinder their clinical translation. The aforementioned limitations could be minimized by implementing combinatorial hybrid systems. With this method, hybrid vesicular systems can integrate the advantages of several carriers into one structure thereby resulting in an increased therapeutic index and better clinical outcome. The current study has reviewed recently introduced types of hybrid vesicles made of polymer-lipids, polymer-peptides, and lipid-peptides, and its main focus is on multiple metallic-based nanoparticles incorporated into vesicular carriers to provide theranostic platforms and to boost the efficient cytotoxic effects of the delivered agents.

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“…Several efforts have recently been made to ameliorate the side effects of DOX [ 2 , 11 ], with the use of lipids and assembled polymers in the delivery of DOX as seen in Doxil™ and Myocet™ which are still associated with mild toxic effects on organs by eliciting proinflammatory cell release [ 12 ], with some other formulations shown having an increase in therapeutic efficiency with few setbacks, such as instability and biphasic release kinetic mechanism [ 13 , 14 ]. However, decrease in toxicity was recorded with liposome conjugated with DOX in a mouse model, although the long-time cumulative effect of the liposome was not documented [ 15 ]. In addition, several organic macromolecules have been employed in nanomedicine for drug delivery [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs

Danmaigoro

Selvarajah

Noor

et al. 2018

Advances in Pharmacological Sciences

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Doxorubicin (DOX) is a potent anticancer agent with cytotoxic effects which limit its clinical usage. This effect is due to its nonselective nature causing injury to the cells as a result of reactive free oxygen radical's release. Cockleshell-derived calcium carbonate nanoparticle (CS-CaCO3NP) is a pH-responsive carrier with targeted delivery potentials. This study aimed at evaluating the toxicity effects of repeated dose administration of DOX-loaded CS-CaCO3NP in healthy dogs. Fifteen dogs with an average body weight of 15 kg were randomized equally into 5 groups. Dogs were subjected to 5 doses at every 3-week interval with (i) normal saline, (ii) DOX, 30 mg/m2, and the experimental groups: CS-CaCO3NP-DOX at (iii) high dose, 50 mg/m2, (iv) clinical dose, 30 mg/m2, and (v) low dose, 20 mg/m2. Radiographs, electrocardiography, and blood samples were collected before every treatment for haematology, serum biochemistry, and cardiac injury assessment. Heart and kidney tissues were harvested after euthanasia for histological and ultrastructural evaluation. The cumulative dose of DOX 150 mg/m2 over 15 weeks revealed significant effects on body weight, blood cells, functional enzymes, and cardiac injury biomarkers with alterations in electrocardiogram, myocardium, and renal tissue morphology. However, the dogs given CS-CaCO3NP-DOX 150 mg/m2 and below did not show any significant change in toxicity biomarker as compared to those given normal saline. The study confirmed the safety of repeated dose administration of CS-CaCO3NP-DOX (30 mg/m2) for 5 cycles in dogs. This finding offers opportunity to dogs with cancer that might require long-term administration of DOX without adverse effects.

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Extensive preclinical investigation of polymersomal formulation of doxorubicin versus Doxil-mimic formulation

Cited by 62 publications

References 34 publications

Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38

Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38

Hybrid Vesicular Drug Delivery Systems for Cancer Therapeutics

Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs

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