Extensive neuronal localization and neurotrophic function of fibroblast growth factor 8 in the nervous system

Tanaka, Akira; Kamiakito, Tomoko; Hakamata, Yoji; Fujii, Akiko; Kuriki, Ken; Fukayama, Masashi

doi:10.1016/s0006-8993(01)02726-3

Cited by 25 publications

(22 citation statements)

References 31 publications

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“…In the adult mouse, mRNA encoding Fgf8 was initially detected only in the testis and ovary by Northern blot (Lorenzi et al 1995, MacArthur et al 1995b), but has subsequently been detected in human prostate, kidney, heart and lung by PCR (Ghosh et al 1996, Schmitt et al 1996, in human and mouse cerebral cortex, human skin and intestine by immunohistochemistry (IHC) (Tanaka et al 2001, Zammit et al 2002 and in blood vessels by PCR (Antoine et al 2005). Within the ovary, Fgf8 mRNA was localised to the oocyte in mice by in situ hybridization (Valve et al 1997) and PCR (Zhong et al 2006), whereas mRNA levels appear low in oocytes, granulosa and theca cells in cattle (Buratini et al 2005) and undetectable in normal human ovary (Valve et al 2000).…”

Section: Ligandsmentioning

confidence: 99%

The fibroblast growth factor 8 family in the female reproductive tract

Estienne¹,

Price²

2018

Reproduction

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Several growth factor families have been shown to be involved in the function of the female reproductive tract. One subfamily of the fibroblast growth factor (FGF) superfamily, namely the FGF8 subfamily (including FGF17 and FGF18), has become important as Fgf8 has been described as an oocyte-derived factor essential for glycolysis in mouse cumulus cells and aberrant expression of FGF18 has been described in ovarian and endometrial cancers. In this review, we describe the pattern of expression of these factors in normal ovaries and uteri in rodents, ruminants and humans, as well as the expression of their receptors and intracellular negative feedback regulators. Expression of these molecules in gynaecological cancers is also reviewed. The role of FGF8 and FGF18 in ovarian and uterine function is described, and potential differences between rodents and ruminants have been highlighted especially with respect to FGF18 signalling within the ovarian follicle. Finally, we identify major questions about the reproductive biology of FGFs that remain to be answered, including (1) the physiological concentrations within the ovary and uterus, (2) which cell types within the endometrial stroma and theca layer express FGFs and (3) which receptors are activated by FGF8 subfamily members in reproductive tissues.Reproduction (2018) 155 R53-R62

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Section: Ligandsmentioning

confidence: 99%

The fibroblast growth factor 8 family in the female reproductive tract

Estienne¹,

Price²

2018

Reproduction

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“…The immunostainings for ER, PgR, and AR were evaluated by both the intensity of the expressions and the ratios of the positive cells, according to the report by Layfield et al with some modification [12]. The FGF8 immunostaining was classified as follows by the method reported by Tanaka et al [22]: -, mostly negative; ±, focal positive or weakly positive; +, distinctly positive in considerable areas; ++, strongly positive. The PSA immunostaining was similarly classified.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Fibroblast growth factor 8 expression in breast carcinoma: associations with androgen receptor and prostate-specific antigen expressions

et al. 2002

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Recent experimental data have clearly demonstrated that fibroblast growth factor (FGF)8 plays a key role in the development of human prostate and breast cancers. However, little is known about the FGF8 expression profile in human breast cancer specimens. In this study, we analyzed FGF8 expression in 78 surgically resected specimens of breast cancer using an immunohistochemical method. In total, FGF8 expression was found in 40 (51.3%) of the breast carcinomas. FGF8 expression was not associated with any of the general clinicopathological parameters, including age, tumor size, histological grade, and histological type. In addition, there was no correlation between FGF8 expression and either c-erbB-2 overexpression or the status of the axillary lymph-node metastasis, both of which have been established as important prognostic factors in breast carcinomas. While no significant association was found between FGF8 expression and estrogen- or progesterone-receptor status, it is of interest that FGF8 expression was significantly associated with androgen-receptor status and the expression of prostate-specific antigen (PSA), one of the androgen-regulated proteins, in human breast carcinomas. These associations support the reported in vitro data demonstrating the regulation of FGF8 by androgens, and also suggest that PSA may be a useful marker for patients with FGF8-expressing breast carcinomas.

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“…For example, FGF-2 and FGF-8 (and its related subfamily members are most robustly expressed during embryonic development, whereas FGF-9 is expressed in the postnatal and adult brain, including the white matter (Nakamura et al, 1999;Xu et al, 1999Xu et al, , 2000Ford-Perriss et al, 2001;Tanaka et al, 2001;Garel et al, 2003;Storm et al, 2003;Hasegawa et al, 2004;Itoh and Ornitz, 2004). Much of the information on FGF signaling in OLs has evolved from the application of FGF-2, which activates all FGF receptors (FGFR1-FGFR4).…”

Section: Introductionmentioning

confidence: 99%

Distinct Fibroblast Growth Factor (FGF)/FGF Receptor Signaling Pairs Initiate Diverse Cellular Responses in the Oligodendrocyte Lineage

Fortin¹,

Rom²,

Sun³

et al. 2005

J. Neurosci.

144

166

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Fibroblast growth factors (FGFs) have been implicated in numerous cellular processes, including proliferation, migration, differentiation, and survival. Whereas FGF-2, the prototypic ligand in a family of 22 members, activates all four tyrosine kinase FGF receptors (FGFR1-FGFR4), other members demonstrate a higher degree of selectivity. Oligodendrocytes (OLs), the myelin-producing cells of the CNS, are highly influenced by FGF-2 at all stages of their development. However, how other FGFs and their cognate receptors orchestrate the development of OLs is essentially undefined. Using a combination of specific FGF ligands and receptor blocking antibodies, we now show that FGF-8 and FGF-17 target OL progenitors, inhibiting their terminal differentiation via the activation of FGFR3, whereas FGF-9 specifically targets differentiated OLs, triggering increases in process growth via FGFR2 signaling; FGF-18 targets both OL progenitors and OLs via activation of both FGFR2 and FGFR3. These events are highly correlated with changes in FGF receptor expression from FGFR3 to FGFR2 as OL progenitors differentiate into mature OLs. In addition, we demonstrate that, although activation of FGFR1 by FGF-2 leads to proliferation of OL progenitors, it produces deleterious effects on differentiated OLs (i.e., aberrant reentry into cell cycle and downregulation of myelin proteins with a loss of myelin membrane). These data suggest that ligand availability, coupled with changes in FGF receptor expression, yield a changing repertoire of ligand-receptor signaling complexes that contribute critically to the regulation of both normal OL development and potential OL/myelin pathogenesis.

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Extensive neuronal localization and neurotrophic function of fibroblast growth factor 8 in the nervous system

Cited by 25 publications

References 31 publications

The fibroblast growth factor 8 family in the female reproductive tract

The fibroblast growth factor 8 family in the female reproductive tract

Fibroblast growth factor 8 expression in breast carcinoma: associations with androgen receptor and prostate-specific antigen expressions

Distinct Fibroblast Growth Factor (FGF)/FGF Receptor Signaling Pairs Initiate Diverse Cellular Responses in the Oligodendrocyte Lineage

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