Extensive multifocal and pleomorphic pulmonary lesions in Waldenström macroglobulinemia: A case report

Zhao, Defeng; Ning, Hao-yong; Cen, Jian; Liu, Yi; Qian, Liren; Han, Zhihai; Shen, Jianliang

doi:10.12998/wjcc.v8.i11.2305

Cited by 1 publication

(1 citation statement)

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“…In domestic literature for the moment there are no cases describing such lesions. However, when analyzing foreign experience, there are descriptions of cases with lesions in the lungs, terminal parts of the colon, stomach, hard palate, and humerus diaphysis [3,6,[9][10][11][12][13][14]. Particularly noteworthy is the damage to the central nervous system, the meninges, and the involvement of the cerebrospinal fluid in the pathological process, which forms the pathogenetic basis of the Bing-Neеl syndrome and is classified as a complication of WM [15].…”

Section: Introductionmentioning

confidence: 99%

Successful Implementation of Combined Treatment Methods for a Rare Recurrence of Waldenstrom Macroglobulinemia With Extramedullary Lesions

Sokolova,

Bochkarnikova

et al. 2024

J Clin Med Res

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A 67-year-old woman was admitted to the Hematology Department in 2014 with complaints of weakness and a low-grade fever. After conducting various tests, it was confirmed that she had Waldenstrom macroglobulinemia. She underwent several rounds of chemotherapy and maintenance therapy with rituximab, which resulted in a good clinical response. However, in 2019, an abnormal growth in the soft tissues of patient’s frontal region was discovered, which was diagnosed as lymphoplasmacytic lymphoma. This later progressed to an intracranial lesion. The patient underwent radiation therapy for both the extramedullary and intracranial growths, which had a positive effect. A year later, she developed a lesion in her lymph nodes and soft tissues of her right leg, which was confirmed to be a recurrence of Waldenstrom disease. She underwent further treatment and is currently in complete remission. This case highlights the rare occurrence of relapse in Waldenstrom disease and the challenges in diagnosing extramedullary lesions. It also demonstrates the success of modern treatment approaches using a combination of therapies.

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