Extensive malignant melanoma of the oral cavity: a rare occurrence

Pradhan, Pradeep; Adhya, Amit Kumar

doi:10.4322/acr.2021.299

Cited by 3 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, there are only a few cases of OMM described in the literature. Due to the lack of symptomatology and nonspecific radiological findings, most of the cases were diagnosed in advanced stages [ 6 , 8 ]. Over 75% of patients had regional lymph node involvement at diagnosis and up to 50% of patients presented with metastatic disease [ 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the lack of symptomatology and nonspecific radiological findings, most of the cases were diagnosed in advanced stages [ 6 , 8 ]. Over 75% of patients had regional lymph node involvement at diagnosis and up to 50% of patients presented with metastatic disease [ 8 , 9 ]. For example, Nisi et al reported in an extensive review, including 447 cases of primary oral AMM, that more than 30% of patients were metastatic at the time of diagnosis [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Challenges in the Diagnosis and Treatment of Oral Amelanotic Malignant Melanoma: A Case Report

Rosu,

Tolea,

Parosanu

et al. 2024

Cureus

View full text Add to dashboard Cite

Oral malignant melanoma (OMM) is extremely rare and usually has a poor prognosis. Early diagnosis is very important and can improve survival but it is usually difficult due to a lack of symptomatology. We present the first case of a 39-year-old East European woman with oral amelanotic melanoma, who underwent surgery and adjuvant immunotherapy; however, after six months, she developed local recurrence. The patient continued immunotherapy with external radiotherapy targeting the oral tumor recurrence. During therapy, imagistic reevaluation brought evidence of bones, lungs, liver, endotracheal, and brain metastases. Histological differential diagnosis between amelanotic OMM and leiomyosarcoma was necessary to establish the right course of treatment. A series of complications further delayed chemotherapy administration, making the treatment in this case very challenging. The patient had a significant, although late response to immunotherapy, and maintained a good performance status during disease progression with a survival of 15 months until present.

show abstract