Extensive invasive extramammary Paget′s disease: Surgical treatment

Abstract

Extramammary Paget's disease is uncommon. Diagnosis has to be confirmed by histopathology. Treatment is a challenge in cases with extended tumors. We present a 70-year-old male patient with extensive genitoanal Paget's disease. Mohs surgery is the gold standard in such cases. Details of the surgical planning are discussed including wound bed preparation. Radiotherapy may be an alternative.

Extramammary Paget′s disease: Analysis of 17 Chinese cases

“…The mainstay of treatment is wide surgical excision on both the surface and deeply. [17][18][19] Nevertheless, the disease is notorious for its high recurrence rate, ranging between 12% and 58%, with an average of 33%. Mohs micrographic surgery is a surgical technique performed in cases with a high risk of recurrence.…”

Penile tumours: a review

“…). Immunohistochemical staining is positive for EMA, CEA, CK 7, Her‐2 protein, but negative for CK20 and S100 …”

“…Treatment of choice is Mohs surgery followed by split‐thickness skin. Safety margins should be 3 cm to avoid local recurrence . There is a potential risk of invasive growth and metastasis in about 4% of cases .…”

“…Two‐year survival rate of metastatic EPD is 48% . EPD patients warrant a careful follow‐up since up to 15% develop a second cancer, most often in the first 3 years after diagnosis …”

“…Immunohistochemical staining is positive for EMA, CEA, CK 7, Her-2 protein, but negative for CK20 and S100. 62 Treatment of choice is Mohs surgery followed by split-thickness skin. Safety margins should be 3 cm to avoid local recurrence.…”