Extensive Interstitial Collagen Deposition on the Basement Membrane Zone in Allergic Nasal Mucosa

Sanai, Akiko; Nagata, Hiroshi; Konno, Akiyoshi

doi:10.1080/00016489950181026

Cited by 42 publications

(4 citation statements)

References 10 publications

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“…For this reason, we are cautious to consider them as true BMs and we prefer to define them as BM-like structures. Actually, though occasionally, association of Col I with BMs has been previously reported in the nasal mucosa of allergic subjects, 27 in retinal arterioles and venules, 28 in the trabecular beams of human trabecular meshwork, 29 in aged human ciliary body, 30 and in human iris. 31 Curiously, with the exception of the allergic nasal mucosa, all other reports deal with the human eye.…”

Section: Discussionmentioning

confidence: 90%

The Peculiar Pattern of Type IV Collagen Deposition in Epiretinal Membranes

Regoli

Tosi

Neri

et al. 2019

J Histochem Cytochem.

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Idiopathic epiretinal membranes are sheets of tissue that develop in the vitreoretinal interface. They are formed by cells and extracellular matrix, and they are considered the expression of a fibrotic disorder of the eye. Confocal and immunoelectron microscopy of the extracellular matrix of excised membranes, revealed high contents of type IV collagen. It was distributed within epiretinal membranes in basement membrane-like structures associated with cells and in interstitial deposits. In both cases, type IV collagen was always associated with type I collagen. Col IV was also coupled with Col VI and laminin. At high magnification, type IV collagen immunolabelling was associated with interstitial deposits and showed a reticular appearance due to the intersection of beaded microfilaments. The microfilaments are about 12 nm in diameter with interbead distance of 30–40 nm. Cells of the epiretinal membranes showed intracellular lysosome-like bodies heavily labeled for type IV collagen suggesting an active role in membrane remodeling. Hence, type IV collagen is not necessarily always associated with basement membranes; the molecular interactions that it may develop when not incorporated in basement membranes are still unknown. It is conceivable, however, that they might have implications in the progression of epiretinal membranes and other fibrotic disorders.

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Section: Discussionmentioning

confidence: 90%

The Peculiar Pattern of Type IV Collagen Deposition in Epiretinal Membranes

Regoli

Tosi

Neri

et al. 2019

J Histochem Cytochem.

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“…We have also found numerous CD68-immunoreactive macrophages, presumably belonging to the population of antigen presenting cells [12]. Distribution of collagen type IV and laminin revealed by immunostaining in the tumour did not deviate from the pattern observed in normal nasal mucosa [13]. …”

Section: Discussionmentioning

confidence: 89%

Respiratory epithelial adenomatoid hamartoma of the anterior nasal septum a rare localisation of an unusual tumour in a child: a case report

Gajda

Zagólski

Jasztal

et al. 2009

Cases J

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IntroductionHamartomas are non-neoplastic lesions constituted by a mixture of tissues indigenous to the region. Respiratory epithelial adenomatoid hamartomas are characterised by glandular proliferation lined by ciliated airway epithelium. Their localisation in the nasal cavity is rare and most frequent cases described so far were associated with the posterior nasal septum.Case presentationA 9-year-old Caucasian boy presented with long-standing nasal obstruction. A large right nasal mass was evident on physical and CT examinations. It was surgically removed from the anterior nasal septum under general anaesthesia. Histologically, the diagnosis of REAH was established. The tumour lined by stratified squamous and ciliated respiratory epithelium was characterised by prominent glandular proliferation. By immunohistochemistry, the tumour was positive for cytokeratins, smooth muscle actin, vimentin, laminin, collagen type IV, CD8, and CD68. No S-100 immunoreactivity was observed. The patient has been asymptomatic for 12 months with completely healed lining of the nose.ConclusionRespiratory epithelial adenomatoid hamartoma, although rare, must be taken into consideration in differential diagnosis of nasal exophytic lesions.

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“…Remodeling occurs in the nasal mucosa of AR patients,22,23 although it appears that remodeling in the nose is less extensive than in the lungs 4. One of the aims of this study was to establish a model of acute AR as well as a model of prolonged allergen-induced nasal airway inflammation to mimic the tissue remodeling that is observed in chronic AR.…”

Section: Discussionmentioning

confidence: 99%

Roles of Periostin in Symptom Manifestation and Airway Remodeling in a Murine Model of Allergic Rhinitis

Hur

Khalmuratova

Ahn

et al. 2012

Allergy Asthma Immunol Res

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PurposePeriostin was originally identified as a secreted factor during screening of a mouse osteoblastic library. In a recent study, periostin was found to directly regulate eosinophil accumulation in allergic mucosal inflammation. Chronic eosinophilic inflammation is related to the development of remodeling. The present study examined the expression of periostin and evaluated its role in the inflammatory process and remodeling associated with allergic rhinitis.MethodsA murine model of allergic rhinitis was established in periostin knockout mice. We analyzed the expression of periostin, manifestation of nasal symptoms, eosinophilic inflammation, and subepithelial fibrosis as well as the expression of MMP-2, TIMP-1, and type 1 collagen in nasal tissue.ResultsPeriostin was mainly distributed in the subepithelial tissue of the nasal mucosa. The subepithelial tissue was thinner in the knockout group than in the control group. No differences in the expression of MMP-2 or TIMP-1 were found in the knockout group. However, after a month of allergen challenge, type I collagen in the nasal tissue was lower in the knockout group than in the control group. The number of eosinophils and the symptom score were also lower in the knockout group.ConclusionsPeriostin is expressed in nasal tissues of murine models of allergic rhinitis. Periostin deficiency may affect the remodeling of nasal tissue with reduced subepithelial fibrosis, and lead to less eosinophilic inflammation.

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Extensive Interstitial Collagen Deposition on the Basement Membrane Zone in Allergic Nasal Mucosa

Cited by 42 publications

References 10 publications

The Peculiar Pattern of Type IV Collagen Deposition in Epiretinal Membranes

The Peculiar Pattern of Type IV Collagen Deposition in Epiretinal Membranes

Respiratory epithelial adenomatoid hamartoma of the anterior nasal septum a rare localisation of an unusual tumour in a child: a case report

Roles of Periostin in Symptom Manifestation and Airway Remodeling in a Murine Model of Allergic Rhinitis

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