2014
DOI: 10.1038/hdy.2014.33
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Extensive heterosis in growth of yeast hybrids is explained by a combination of genetic models

Abstract: Heterosis, also known as hybrid vigor, is the superior performance of a heterozygous hybrid relative to its homozygous parents. Despite the scientific curiosity of this phenotypic phenomenon and its significance for food production in agriculture, its genetic basis is insufficiently understood. Studying heterosis in yeast can potentially yield insights into its genetic basis, can allow one to test the different hypotheses that have been proposed to explain the phenomenon and allows better understanding of how … Show more

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Cited by 57 publications
(80 citation statements)
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References 47 publications
(70 reference statements)
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“…We observed substantial heterosis for a number of traits in our diallel (Fig 1), including high levels of heterosis for grain yield consistent with reports in other maize diallel populations [70]. Heterosis has been observed across many species, from yeast [71] to plants [72] and vertebrates [73], and a number of hypotheses have been put forth to explain the phenomenon [11,21]. Of all these explanations, complementation of recessive deleterious alleles [12,21] remains the simplest genetic explanation and is supported by considerable empirical evidence [22,23,74].…”
Section: Discussionsupporting
confidence: 73%
“…We observed substantial heterosis for a number of traits in our diallel (Fig 1), including high levels of heterosis for grain yield consistent with reports in other maize diallel populations [70]. Heterosis has been observed across many species, from yeast [71] to plants [72] and vertebrates [73], and a number of hypotheses have been put forth to explain the phenomenon [11,21]. Of all these explanations, complementation of recessive deleterious alleles [12,21] remains the simplest genetic explanation and is supported by considerable empirical evidence [22,23,74].…”
Section: Discussionsupporting
confidence: 73%
“…However, calling such contributions is challenging because multiple effects often act in parallel. In particular, overdominance may be modified by epistasis such that it only manifests in a minority of genetic backgrounds31. Thus, a QTL may not be overdominant in the average genetic background, but could nevertheless account for best parent heterosis in some lineages.…”
Section: Resultsmentioning
confidence: 99%
“…Outbred hybrids, i.e., those formed by hydridization between spores (segregants) from two different parent strains, in particular tended to show a greater increase in ester production compared to inbred hybrids, i.e., those formed by hydridization between spores (segregants) derived from a single parent strain. It has been shown that heterosis in regard to the growth rates of yeast hybrids formed from domesticated parent strains is positively correlated with sequence divergence (Plech et al 2014; Shapira et al 2014). However, Steensels et al (2014) did not see an increase in 3-methylbutyl acetate formation as the genetic distance of the parent strains was increased.…”
Section: Hybrid Phenotypesmentioning
confidence: 99%