Extensive genomic conservation of cattle microsatellite heterozygosity in sheep

Gortari, Maurico J. de; Freking, B. A.; Kappes, S. M.; Leymaster, K. A.; Crawford, A. M.; Stone, R. T.; Beattie, Craig W.

doi:10.1111/j.1365-2052.1997.00153.x

Cited by 59 publications

(39 citation statements)

References 74 publications

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“…Diversity estimates in this study are lower than the observed frequencies of heterozygotes reported in other species using microsatellite markers. For instance, in human populations the average heterozygote frequency ranges between 0.7 and 0.8 [2], in cattle-0.6 [11], in pigs-0.68 [21] and in fish-0.86 [16]. Although such comparisons are difficult to interpret, the lower variability in chickens calls attention to the importance of conserving the chicken gene pool.…”

Section: Genetic Diversity Of Populationsmentioning

confidence: 99%

Biodiversity of 52 chicken populations assessed by microsatellite typing of DNA pools

Groenen²,

et al. 2003

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-In a project on the biodiversity of chickens funded by the European Commission (EC), eight laboratories collaborated to assess the genetic variation within and between 52 populations from a wide range of chicken types. Twenty-two di-nucleotide microsatellite markers were used to genotype DNA pools of 50 birds from each population. The polymorphism measures for the average, the least polymorphic population (inbred C line) and the most polymorphic population (Gallus gallus spadiceus) were, respectively, as follows: number of alleles per locus, per population: 3.5, 1.3 and 5.2; average gene diversity across markers: 0.47, 0.05 and 0.64; and proportion of polymorphic markers: 0.91, 0.25 and 1.0. These were in good agreement with the breeding history of the populations. For instance, unselected populations were found to be more polymorphic than selected breeds such as layers. Thus DNA pools are effective in the preliminary assessment of genetic variation of populations and markers. Mean genetic distance indicates the extent to which a given population shares its genetic diversity with that of the whole tested gene pool and is a useful criterion for conservation of diversity. The distribution of populationspecific (private) alleles and the amount of genetic variation shared among populations supports the hypothesis that the red jungle fowl is the main progenitor of the domesticated chicken.genetic distance / polymorphism / red jungle fowl / DNA markers / domesticated chicken

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Section: Genetic Diversity Of Populationsmentioning

confidence: 99%

Biodiversity of 52 chicken populations assessed by microsatellite typing of DNA pools

Groenen²,

et al. 2003

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“…The families used to construct the ovine linkage map have been described previously (Crawford et al 1995;de Gortari et al 1997). Briefly, the AgResearch International Mapping Flock (IMF) consists of nine, three-generation full-sib pedigrees with a total of 98 progeny.…”

Section: Methodsmentioning

confidence: 99%

A second-generation linkage map of the sheep genome

et al. 1998

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deGortari, Maurico J.; Freking, Brad A.; Cuthbertson, Rachel P.; Kappes, Steven M.; Keele, John W.; Stone, Roger T.; Leymaster, Kreg A.; Dodds, Ken G.; Crawford, Allan M.; and Beattie, Craig W., "A second-generation linkage map of the sheep genome" (1998 (Crawford et al., Genetics 140, 703, 1995) and the USDA mapping flock. Seventy-three percent (370/504) of the microsatellite markers on the map are common to the USDA-ARS MARC cattle linkage map, with 27 of the common markers derived from sheep. The number of common markers per homologous linkage group ranges from 5 to 22 and spans a total of 2866 cM (sex average) in sheep and 2817 cM in cattle. Marker order within a linkage group was consistent between the two species with limited exceptions. The reported translocation between the telomeric end of bovine Chr 9 (BTA 9) and BTA 14 to form ovine Chr 9 is represented by a 15-cM region containing 5 common markers. The significant genomic conservation of marker order will allow use of linkage maps in both species to facilitate the search for quantitative trait loci (QTLs) in cattle and sheep.

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“…Although no RH panel for sheep was available, the high conservation in sequence content and marker order between sheep and cattle (Cockett et al 1994;de Gortari et al 1997) suggested that the bovine RH panels would allow accurate preliminary estimations of the ovine physical map. Cell lines from the BovR5 RH panel were amplified with 10 primer pairs representing type-I (CKB, PREF-1, PAP, BDKRB2, AKT, EMAPL, and YY1) and type-II (IDVGA-30, BMS2382, and OBDS567) loci.…”

Section: Resultsmentioning

confidence: 99%

Comparative mapping of the ovine clpg locus

Fahrenkrug

Freking

Rexroad

et al. 2000

Incorporating Mouse Genome

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Abstract. We used a comparative mapping approach to identify segments of conserved synteny between human Chromosome 14 (HSA14), bovine Chromosome 21 (BTA21), and the portion of ovine Chromosome 18 (OAR18) that contains the clpg locus. A bovine radiation hybrid map of the region was constructed with available Type II genetic markers and seven candidate genes to establish the comparative interval between BTA21 and HSA14. We developed polymorphic microsatellite and SNP markers associated with five candidate genes and placed them on the ovine and/or bovine genetic maps by multipoint linkage analysis. Three additional genes were mapped by virtue of their physical linkage to genetically mapped makers. Development of integrated linkage and physical maps facilitates the selection of positional candidate genes from the gene rich human map. The physically linked candidate genes PREF-1 and MEG3 map to the interval containing the clpg locus. Comparative biology suggests imprinting of MEG3 and/or the influences of PREF-1 on cellular differentiation, should be examined for their role in the parent-of-origin dependent influence of mutant clpg alleles on sheep muscle characteristics.

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Extensive genomic conservation of cattle microsatellite heterozygosity in sheep

Cited by 59 publications

References 74 publications

Biodiversity of 52 chicken populations assessed by microsatellite typing of DNA pools

Biodiversity of 52 chicken populations assessed by microsatellite typing of DNA pools

A second-generation linkage map of the sheep genome

Comparative mapping of the ovine clpg locus

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