Extensive development of vulnerable plaques as a pan-coronary process in patients with myocardial infarction: an angioscopic study

Asakura, Masanori; Ueda, Yasunori; Yamaguchi, Osamu; Adachi, Takahiro; Hirayama, Atsushi; Hori, Masatsugu; Kodama, Kazuhisa

doi:10.1016/s0735-1097(01)01135-4

Cited by 355 publications

(193 citation statements)

References 18 publications

Supporting

Mentioning

175

Contrasting

Unclassified

Order By: Relevance

“…There was no significant difference of smoking status between low HDL-C group and normal HDL-C group (p=0.546). This result was correlated with the study of Asakura et al 26 that 56.0% of their patients were smoker. This result was also correlated with the study of Kabir et al 27 that 60.0% of their patients of CAD were smoker.…”

Section: Materials and Methodsupporting

confidence: 90%

See 1 more Smart Citation

Relationship between HDL-Cholesterol and Angiographic Severity of Coronary Artery Disease

Ahmed

Akhtaruzzaman²,

Rahman

et al. 2018

Bangladesh Heart J

View full text Add to dashboard Cite

Abstract:Background: Dyslipidaemias is one of the major risk factor for Coronary artery diseases (CAD).There is an inverse correlation between high density lipoprotein cholesterol (HDL-C) and the risk of coronary artery disease. Understanding the angiographic characteristics of coronary artery diseases (CAD) in low and normal HDL-C patients and its association with severity of CAD is very important for future intervention. Although highdensity lipoprotein cholesterol (HDL-C) is well established predictor of future cardiovascular event, little information is available regarding its correlation with the prevalence and severity of angiographically evaluated coronary artery diseases (CAD). Conclusion: It may be concluded that low HDL-C level is associated with angiographically more severe coronary artery diseases reflected by vessels score and Friesinger score as compared to normal or high HDL-C level.

show abstract

Section: Materials and Methodsupporting

confidence: 90%

“…This result was also supported by Okamatsu et al 30 that 54.0% of their patients were hypertensive. In this regards Asakura et al 26 found 60.0% of their patient were hypertensive.…”

Section: Materials and Methodmentioning

confidence: 83%

Relationship between HDL-Cholesterol and Angiographic Severity of Coronary Artery Disease

Ahmed

Akhtaruzzaman²,

Rahman

et al. 2018

Bangladesh Heart J

View full text Add to dashboard Cite

show abstract

“…This could contribute to the explanation of the pan-coronary syndrome. 1,2 It has been suggested that increased endothelial apoptosis leads to atheroma denudation and subsequent coronary thrombosis. [5][6][7][8][9]24 Endothelial apoptosis could also increase susceptibility toward coronary thrombosis through the release of apoptotic cell debris into the blood stream, which is known to directly activate coagulation cascade.…”

Section: Original Findingsmentioning

confidence: 99%

“…1,2 The finding that patients immediately after AMI are at increased risk for additional acute coronary events caused by previously nonoffending plaques 3,4 has generated the hypothesis that circulating factors induce vascular smooth muscle and endothelial damages that in turn could be responsible for plaque activation. Several studies have demonstrated the presence of apoptosis in atherosclerotic plaques that could lead to plaque denudation and subsequent transition to vulnerability.…”

mentioning

confidence: 99%

Serum From Patients With Acute Coronary Syndromes Displays a Proapoptotic Effect on Human Endothelial Cells

et al. 2003

View full text Add to dashboard Cite

Background-Endothelial apoptosis of atherosclerotic lesions is a possible determinant for the stable-to-vulnerable plaque transition.Recent data support the notion that plaque activation may be a pan-coronary process, advocating the existence of circulating triggers. Methods and Results-Serum from 40 healthy subjects (group 1) and 73 patients with stable angina (nϭ32; group 2) or acute coronary syndromes (nϭ41; group 3) was incubated with human umbilical vein endothelial cells. The percentage of apoptosis by flow cytometry and Fas, Bax, and Bcl-2 protein expression by immunoblotting were evaluated at entry in patients and control subjects and repeated after 12 months in group 3. At baseline, apoptotic nuclei were higher in group 3 (14Ϯ6%) than in group 2 (3.3Ϯ1.8%) and group 1 (1.35Ϯ0.8%) (PϽ0.001). Fas and Bcl-2 were increased in group 3 with respect to groups 1 and 2 (PϽ0.01). Coincubation of group 3 serum with anti-tumor necrosis factor-␣ and anti-interleukin-6 monoclonal antibodies did not affect the human umbilical vein endothelial cell apoptotic process, whereas addition of Trolox decreased apoptosis to Ͻ50%. The percentage of apoptosis in group 3 significantly correlated to the numbers of coronary complex lesions at angiography (rϭ0.58, PϽ0.0005). In group 3, apoptosis and the Bax/Bcl-2 ratio decreased at 1 year (PϽ0.0001, PϽ0.05 respectively). Conclusions-Serum from patients with acute coronary syndromes displays a proapoptotic effect on human endothelial cells, supporting the theory of the existence of circulating triggers potentially able to activate atherosclerotic lesions.

show abstract

“…Therefore, our result suggests that a low plasma EPA/AA ratio may provide further information regarding the coronary vulnerability of patients with sAP, since the plaque instability represent a 'pan-coronary' process, but not a local vascular accident (13). Indeed, subanalysis of JELIS (3) has shown that adding purified EPA to statin has beneficial effects on the secondary prevention of CAD, and that a low blood EPA/AA ratio is an independent predictor for sudden cardiac death or fatal/nonfatal myocardial infarction in this population (6).…”

Section: Discussionmentioning

confidence: 79%

Association of Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acid Ratio with Complexity of Coronary Artery Lesion

et al. 2012

View full text Add to dashboard Cite

Objective Eicosapentaenoic acid (EPA) of the omega-3 polyunsaturated fatty acids (ω-3 PUFA) family plays important roles in the prevention of cardiovascular disease (CVD), while, arachidonic acid (AA) of the ω-6 PUFA family promotes inflammatory and prothrombotic influences. The complexity of coronary lesions represents the vulnerability of patients. The aim of this study was to investigate the association between the plasma EPA/AA ratio and the prevalence of complex coronary lesion morphology. Methods This study consisted of 206 consecutive patients with stable angina pectoris (sAP). Each coronary lesion was determined either as complex or simple based on angiographic findings. To examine the plasma fatty acid level, blood samples were obtained. Patients were divided into three groups according to the obtained plasma EPA/AA ratio: the highest tertile, n=67, the 2nd tertile, n=70, or the lowest tertile, n=69. Results A higher incidence of complex coronary lesion was obtained from patients with a lower plasma EPA/AA ratio [43 (62%) vs. 31 (44%) vs. 25 (37%), p=0.011]. High-sensitivity CRP levels and a low plasma EPA/AA ratio could independently predict the prevalence of complex coronary lesions on multivariate logistic regression analysis [odds ratio 1.83 (95%CI 1.03-3.25), p=0.038 and odds ratio 2.10 (95%CI 1.11-3.94), p=0.02)]. Conclusion In patients with sAP, a low plasma EPA/AA ratio was significantly associated with a high prevalence of complex coronary lesions.

show abstract

Extensive development of vulnerable plaques as a pan-coronary process in patients with myocardial infarction: an angioscopic study

Abstract: In patients with MI, all three major coronary arteries are widely diseased and have multiple yellow though nondisrupted plaques. Acute MI may represent the pan-coronary process of vulnerable plaque development.

Cited by 355 publications

References 18 publications

Relationship between HDL-Cholesterol and Angiographic Severity of Coronary Artery Disease

Relationship between HDL-Cholesterol and Angiographic Severity of Coronary Artery Disease

Serum From Patients With Acute Coronary Syndromes Displays a Proapoptotic Effect on Human Endothelial Cells

Association of Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acid Ratio with Complexity of Coronary Artery Lesion

Contact Info

Product

Resources

About