Extensive characterizations of bacteria isolated from catheterized urine and stone matrices in patients with nephrolithiasis

Tavichakorntrakool, Ratree; Prasongwattana, Vitoon; Sungkeeree, Seksit; Saisud, Phitsamai; Sribenjalux, Pipat; Pimratana, Chaowat; Bovornpadungkitti, Sombat; Sriboonlue, Pote; Thongboonkerd, Visith

doi:10.1093/ndt/gfs057

Cited by 93 publications

(101 citation statements)

References 9 publications

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“…Furthermore, classically described urease producing bacteria were isolated in only 30% of cases indicating that even urinary bacterial culture is not a reliable predictor for the presence of infection stones during preoperative evaluation. Similar to previous reports in the literature, we found significant heterogeneity among the bacterial isolates, [17][18][19] with the two most common being E. coli and Proteus. While this may suggest an increase in the number of urease-positive E. coli strains, it is more likely that patients are suffering from multi-species urinary tract infections, and E. coli is the most commonly isolated species due to the fact that its short replication rate results in it outcompeting and outgrowing other bacterial species.…”

Section: Discussionsupporting

confidence: 90%

Evaluating factors that dictate struvite stone composition: A multi-institutional clinical experience from the EDGE Research Consortium

Flannigan

Battison

et al. 2017

CUAJ

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Introduction: Struvite stones account for 15% of urinary calculi and are typically associated with urease-producing urinary tract infections and carry significant morbidity. This study aims to characterize struvite stones based on purity of stone composition, bacterial speciation, risk factors, and clinical features. Methods: Retrospective data was collected from patients diagnosed with infection stones between 2008 and 2012. Stone analysis, perioperative urine cultures, bacterial speciation, and clinical data were collected and analyzed. The purity of struvite stones was determined. Statistical comparisons were made among homogeneous and heterogeneous struvite stones. Results: From the four participating centres, 121 struvite stones were identified. Only 13.2% (16/121) were homogenous struvite. Other components included calcium phosphate (42.1%), calcium oxalate (33.9%), calcium carbonate (27.3%), and uric acid (5.8%). Partial or full staghorn calculi occurred in 23.7% of cases. Urease-producing bacteria were only present in 30% of cases. Proteus, E. coli, and Enterococcus were the most common bacterial isolates from perioperative urine, and percutaneous nephrolithotomy was the most common modality of treatment. Only 40% of patients had a urinalysis that was nitrite-positive, indicating that urinalysis alone is not reliable for diagnosing infection stones. The study's limitations is its retrospective nature; as such, the optimal timing of cultures with respect to stone analysis or treatment was not always possible, urine cultures were often not congruent with stone cultures in the same patient, and our findings of E. coli commonly cultured does not suggest causation.

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Section: Discussionsupporting

confidence: 90%

Evaluating factors that dictate struvite stone composition: A multi-institutional clinical experience from the EDGE Research Consortium

Flannigan

Battison

et al. 2017

CUAJ

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“…Though there is a significant relation between the presence of calculi and UTI, it is not certain which one is the cause and which is the effect, as in the principle "which was the first: the chicken or the egg?". In some situations the chemical contents of calculi may indicate the etiology of calculi, as a chronic UTI can induce the development of magnesium ammonium phosphate based calculi, whereas newer studies presented other types of calculi as well, following UTI (10,19). The urinary calculi are developed mostly de novo in renal site (20).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies showed that the urinary lithiasis can be induced by chronic or persistent UTI (so-called "infection-induced stones"). In contrast, there is a similar strong evidence that the presence of calculi are risk factors for UTI (so-called "stones with subsequent infections") (7,8,10). In these situations, the bacteria from calculi and urine are the same.…”

Section: Introductionmentioning

confidence: 99%

Bacteriological evaluation of the non-struvite nephrolithiasis and its association with urinary tract infections

Maier

Man

Chibelean

et al. 2015

Revista Romana De Medicina De Laborator

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“…Urinary tract infection (UTI) and USD often occur in the same patients: 34% of children with USD had associated UTIs, and only 1.3% had underlying structural anomalies of the urinary tract (27). Furthermore, bacteria have been cultured from between 19% and 32% of calcium oxalate stones (28). Additional investigation is required to determine the extent to which this calcium oxalate USD-UTI link is causal or merely coincidental.…”

Section: Microbiotamentioning

confidence: 99%

Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health

Scales

Tasian

Schwaderer

et al. 2016

CJASN

122

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Expanding epidemiologic and physiologic data suggest that urinary stone disease is best conceptualized as a chronic metabolic condition punctuated by symptomatic, preventable stone events. These acute events herald substantial future chronic morbidity, including decreased bone mineral density, cardiovascular disease, and CKD. Urinary stone disease imposes a large and growing public health burden. In the United States, 1 in 11 individuals will experience a urinary stone in their lifetime. Given this high incidence and prevalence, urinary stone disease is one of the most expensive urologic conditions, with health care charges exceeding $10 billion annually. Patient care focuses on management of symptomatic stones rather than prevention; after three decades of innovation, procedural interventions are almost exclusively minimally invasive or noninvasive, and mortality is rare. Despite these advances, the prevalence of stone disease has nearly doubled over the past 15 years, likely secondary to dietary and health trends. The NIDDK recently convened a symposium to assess knowledge and treatment gaps to inform future urinary stone disease research. Reducing the public health burden of urinary stone disease will require key advances in understanding environmental, genetic, and other individual disease determinants; improving secondary prevention; and optimal population health strategies in an increasingly cost-conscious care environment.

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Extensive characterizations of bacteria isolated from catheterized urine and stone matrices in patients with nephrolithiasis

Cited by 93 publications

References 9 publications

Evaluating factors that dictate struvite stone composition: A multi-institutional clinical experience from the EDGE Research Consortium

Evaluating factors that dictate struvite stone composition: A multi-institutional clinical experience from the EDGE Research Consortium

Bacteriological evaluation of the non-struvite nephrolithiasis and its association with urinary tract infections

Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health

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