Extensive Biopsy Protocol Improves the Detection Rate of Prostate Cancer

Ravery, V.; Goldblatt, Laurent; Royer, B.; Blanc, Emmanuel; Toublanc, M.; Boccon-Gibod, L

doi:10.1016/s0022-5347(05)67368-5

Cited by 143 publications

(49 citation statements)

References 12 publications

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“…That was probably because that TP biopsy was targeted to the lateral, apico-dorsal peripheral and transition zones in the routine biopsy might increase PCa detection rates [8–11]. In addition, previous studies had recommended an increase in the number of biopsy cores [12–14]. However, the number of biopsies required for optimizing the diagnosis of PCa was still controversial.…”

Section: Introductionmentioning

confidence: 99%

Comparison between transrectal and transperineal prostate biopsy for detection of prostate cancer: a meta-analysis and trial sequential analysis

et al. 2017

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To systematically assess the efficacy and complications of transrectal (TR) versus transperineal (TP) prostate biopsy in the detection of prostate cancer (PCa). A meta-analysis was performed by searching the databases Pubmed, Embase and Web of science for the relevant available studies until September 1st, 2016, and thirteen studies met the inclusion criteria. The pooled odds ratios with 95% confidence intervals were calculated to evaluate the differences of TR and TP groups in PCa detection rate. Then, trial sequential analysis was performed to reduce the risk of type I error and estimated whether the evidence of the results was reliable. Overall, this meta-analysis included a total of 4280 patients, who had been accrued between April 2000 and Aug 2014 and randomly divided into TR group and TP group. Prostate biopsies included sextant, extensive and saturation biopsy procedures. Patients who received TP prostate biopsy had no significant improvement in PCa detection rate, comparing TR group. Moreover, when comparing TR and TP studies, no significant difference was found in abnormal DRE findings, serum PSA level measurement, Gleason score, prostate volume. Besides, this meta-analysis showed no obvious differences between these two groups in terms of relevant complications. Therefore, this meta-analysis revealed that no significant differences were found in PCa detection rate between TP and TR approaches for prostate biopsy. However, with regard to pain relief and additional anesthesia, TR prostate needle biopsy was relatively preferable, compared to TP prostate biopsy.

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Section: Introductionmentioning

confidence: 99%

Comparison between transrectal and transperineal prostate biopsy for detection of prostate cancer: a meta-analysis and trial sequential analysis

et al. 2017

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“…Although Hodge et al 4 first proposed sextant biopsy under transrectal ultrasound guidance, in 1989, some recent reports have indicated that systematic sextant biopsy might be inadequate for cancer detection. [5][6][7] We also thought that a core number of more than 6 may be needed to detect more cancers, and we chose a core number of 12, with which a greater number of core samples would be obtained from the peripheral zone.…”

Section: Introductionmentioning

confidence: 99%

Transperineal ultrasound-guided 12-core systematic biopsy of the prostate for patients with a prostate-specific antigen level of 2.5–20 ng/ml in Japan

et al. 2004

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We demonstrated a high prostate cancer detection rate by the transperineal ultrasound-guided 12-core systematic biopsy method in patients with PSA levels of 2.5 to 20 ng/ml. Accordingly, if the number of core biopsies is further increased overall, except in patients with a large prostate volume, and if the indication for biopsy is decided based on the PSAD and %f PSA, then the cancer detection rate by the present method may be further improved, with fewer unnecessary biopsies.

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“…Likewise, Levine et al [13] found that performing two consecutive sets of sextant biopsies increased detection of clinically significant prostate cancers by 30%. A 10-biopsy strategy was shown to improve prostate cancer detection by 6.5% [14]. In this study, the additional biopsies were directed more laterally than the standard sextant.…”

Section: Optimizing Number Of Cores and Direction Of Biopsy Needlesmentioning

confidence: 97%

“…No difference Ravery et al [14] 10 No difference PSA-detected prostate cancers are infiltrative and nonpalpable, conventional imaging modalities fail to detect prostate cancer reliably. Researchers are working to overcome this problem by improving already existing imaging modalities and developing new ones.…”

Section: Imagingmentioning

confidence: 99%

How to improve prostate biopsy detection of prostate cancer

Ornstein

Kang

2001

Curr Urol Rep

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The combination of serum prostate-specific antigen (PSA) testing and transrectal ultrasonography is a highly effective strategy to diagnose prostate cancer at an early curable stage. Even though PSA is the most useful serum biomarker to aid in prostate cancer detection, it has limited specificity: as many as 75% of men who undergo prostate biopsy because of an elevated PSA do not have prostate cancer. Additionally, sextant prostate biopsies miss prostate cancer at least 20% of the time. To reduce the number of false-negative biopsies, many have advocated obtaining 12 or more cores in a single biopsy session. Studies have shown that this practice is safe and can enhance cancer detection modestly. Although it is unlikely that prostate cancer imaging will replace prostate biopsy in the near future, many exciting new imaging technologies should eventually improve targeting of prostate needle biopsy and reduce false-negative biopsies. Some of the most exciting areas include power Doppler sonography, microbubble intravenous ultrasound contrast agents, and magnetic resonance spectroscopy. These functional imaging modalities can assess tumor blood flow and metabolic activity at a cellular level and can detect malignant changes that may not be detected by standard anatomic imaging.

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Extensive Biopsy Protocol Improves the Detection Rate of Prostate Cancer

Abstract: Increasing the number of biopsy cores and improving prostate peripheral zone sampling resulted in a significant improvement in the detection of prostate cancer.

Cited by 143 publications

References 12 publications

Comparison between transrectal and transperineal prostate biopsy for detection of prostate cancer: a meta-analysis and trial sequential analysis

Comparison between transrectal and transperineal prostate biopsy for detection of prostate cancer: a meta-analysis and trial sequential analysis

Transperineal ultrasound-guided 12-core systematic biopsy of the prostate for patients with a prostate-specific antigen level of 2.5–20 ng/ml in Japan

How to improve prostate biopsy detection of prostate cancer

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