Extension of the H-2 TLb molecular map

Gd, Brown; Choi, Yechin; Egan, G; Meruelo, Daniel

doi:10.1007/bf00376118

Cited by 27 publications

(3 citation statements)

References 40 publications

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“…Mapping Hmt with Tia region probes The Tia region encompasses at least 19 genes in BALB/c (1la') ( Figure 2) and 15 genes in B6 and BlO (Th7a) (Brown et al, 1988). It was therefore possible that Hmt mapped within the Tla region but distal to the gene encoding the TL antigen in CAS3 (corresponding to gene T13c).…”

Section: Resultsmentioning

confidence: 99%

Genetic and molecular mapping of the Hmt region of mouse.

et al. 1989

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We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx‐1, thus including Pgk‐2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk‐2, within the distal inversion in t‐haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.

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Section: Resultsmentioning

confidence: 99%

Genetic and molecular mapping of the Hmt region of mouse.

et al. 1989

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“…Northern blotting and hybridization were carried out as described previously (18). Hybridization probes used were H-2 IIa(sub), a broadly cross-reactive cDNA subclone of H-2 IIa lacking the repetitive sequences (19,20); ATF-1, excised by BamHI and HindIII from the ATF-1A clone (see Fig. 1); and ␤-actin (21).…”

Section: Methodsmentioning

confidence: 99%

Activation Transcription Factor 1 Involvement in the Regulation of Murine H-2D Expression

Ishiguro

Brown

Meruelo

1997

Journal of Biological Chemistry

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Resistance to radiation leukemia virus-induced leukemia is correlated with an increase in H-2D expression on the thymocyte surface. Recently, it has been shown that elevated H-2D d expression on the infected thymocyte is a result of elevated mRNA transcription and that the transcriptional increase is correlated with elevated levels of a DNA binding activity, H-2 binding factor 1 (H-2 BF1), which recognizes the 5 -flanking sequences (5 -TGACGCG-3 ) of the H-2D d gene. This target for transcription factor binding has been found to be identical in the 5 -regulatory region of 12 rodent class I genes, nine of which have been shown to be functional genes. Furthermore, this cis-element is found 5 of 20 primate class I genes (15 human genes), seven of which are known to be functional. Here, we demonstrate that activation transcription factor 1 (ATF-1) is one component of H-2 BF1. In addition, the levels of ATF-1 mRNA in uninfected and radiation leukemia virus-infected thymocytes parallel those of H-2D d mRNA, and therefore, it is suggested that ATF-1 up-regulates the transcription of the H-2D d gene after radiation leukemia virus infection of thymocytes. Transfection experiments also demonstrate that ATF-1 activates a reporter plasmid that contains the H-2 BF1 motif, but not a reporter lacking this motif. This is the first demonstration of the interaction of ATF-1 with 5 -regulatory sequences of major histocompatibility complex class I genes.

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“…The Qa antigens are widely distributed on these tissues, but the TL antigens are expressed only on thymocytes at certain stages of differentiation and on some leukemias. The polymorphism of the Qa and T/a loci is much lower than that of the K and D loci, and fewer gene products have been identified compared to the number of genes mapped to this region (approximately 10 Qa genes, and 15 T/a genes in H-2 b and 18 in H-2d; Hood et al 1983, Brown et al 1988. They appear to be considerably less polymorphic than the classical class I antigens, and their heavy chains can vary in size from Mr 40 000 to Mr 45 000.…”

Section: Introductionmentioning

confidence: 98%

TheRT1.G locus in the rat encodes a Qa/TL-like antigen

et al. 1989

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A new antigenic system in the rat homologous to the Qa/TL antigen system in the mouse has been characterized. It was detected by antibodies raised in donor-recipient combinations that were matched for the RT1.A, B, D, E loci in the major histocompatibility complex (MHC): (R11 X BN)F1 anti-BN.1L(LEW), (R18 X BN)F1 anti-BN.1L, and BN.1LV1(F344) anti-BN.1L. Absorption analyses using these antisera and a variety of inbred, congenic, and recombinant strains identified three alleles, RT1.Ga, Gb, Gc, of which Gc is a null allele. The strain distribution of these alleles was determined using 37 strains of rats representative of all of the prototypic haplotypes and a number of congenic and recombinant strains. The use of the congenic and recombinant strains showed that the RT1.G locus was linked to the MHC and that the most probable gene order was A-E-G. Testcross analysis showed that the map distance between A and G was 1.4 cM (4/285 recombinants). The RT1.G antigen has a heavy chain of Mr 46,000 and is present on both T and B cells.

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Extension of the H-2 TLb molecular map

Cited by 27 publications

References 40 publications

Genetic and molecular mapping of the Hmt region of mouse.

Genetic and molecular mapping of the Hmt region of mouse.

Activation Transcription Factor 1 Involvement in the Regulation of Murine H-2D Expression

TheRT1.G locus in the rat encodes a Qa/TL-like antigen

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