“…The plasma separation is achieved with an integrated nanofilter comprising an array of nanowells. So far, waveguide absorption spectroscopy has been demonstrated for sensing pH value, protein, − and molecules. − Separation of blood plasma and RBCs is achieved by either active methods, such as magnetic, , dielectrophoretic, , and acoustic, , or passive methods, such as hydrodynamic, − sedimentation, , and filtration. − Our optofluidic strategy is based on an innovative dual function of nanofilters that act as a component of the waveguide as well as a functional filter for RBCs. The nanofilters enable light propagation without diffraction and scattering while effectively blocking cells or platelets with short diffusion length and time, as shown schematically in Figure a.…”