Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin

Bonilla, Ernesto; Medina-Leendertz, Shirley; Díaz, Solangel Valdés

doi:10.1016/s0531-5565(01)00229-7

Cited by 99 publications

(72 citation statements)

References 54 publications

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“…Melatonin supplementation experiments generally reveal a positive effect of melatonin on survival in both vertebrates and invertebrates [67][68][69][70]. Similarly, a number of studies have found melatonin plays a fundamental role in immune-modulation, but this has been explored almost exclusively in vertebrates (for recent reviews see [71][72][73]).…”

Section: (B) Melatonin and Circadian Rhythmmentioning

confidence: 99%

Melatonin: a possible link between the presence of artificial light at night and reductions in biological fitness

Jones

Durrant

Michaelides

et al. 2015

Phil. Trans. R. Soc. B

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The mechanisms underpinning the ecological impacts of the presence of artificial night lighting remain elusive. One suspected underlying cause is that the presence of light at night (LAN) supresses nocturnal production of melatonin, a key driver of biological rhythm and a potent antioxidant with a proposed role in immune function. Here, we briefly review the evidence for melatonin as the link between LAN and changes in behaviour and physiology. We then present preliminary data supporting the potential for melatonin to act as a recovery agent mitigating the negative effects of LAN in an invertebrate. Adult crickets ( Teleogryllus commodus ), exposed to constant illumination, were provided with dietary melatonin (concentrations: 0, 10 or 100 µg ml −1 ) in their drinking water. We then compared survival, lifetime fecundity and, over a 4-week period, immune function (haemocyte concentration, lysozyme-like and phenoloxidase (PO) activity). Melatonin supplementation was able only partially to mitigate the detrimental effects of LAN: it did not improve survival or fecundity or PO activity, but it had a largely dose-dependent positive effect on haemocyte concentration and lysozyme-like activity. We discuss the implications of these relationships, as well as the usefulness of invertebrates as model species for future studies that explore the effects of LAN.

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Section: (B) Melatonin and Circadian Rhythmmentioning

confidence: 99%

Melatonin: a possible link between the presence of artificial light at night and reductions in biological fitness

Jones

Durrant

Michaelides

et al. 2015

Phil. Trans. R. Soc. B

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“…Melatonin (Bonilla et al 2002;Izmaylov and Obukhova 1999;Anisimov et al 1997). However, with the exception of Coenzyme Q 10 , the other antioxidants mentioned have been shown to have differing lifespan effects both in the same organism (Harrington and Harley 1988;Adachi and Ishii 2000;Ishii et al 2004;Driver and Georgeou 2003) and between species (Driver and Georgeou 2003;Bonilla et al 2002;Izmaylov and Obukhova 1999;Anisimov et al 1997;Anisimov 2003).…”

Section: Pharmacological Interventions That Increase Lifespanmentioning

confidence: 99%

Pharmacological intervention in invertebrate aging

Lithgow

Gill

Olsen

et al. 2005

AGE

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Prompted by successful genetic interventions in aging we now consider the utility of pharmacological interventions. A few clear cases of lifespan extension resulting from exposure to compounds suggest that aging can be slowed and that the pharmacology of lifespan extension is a feasible area for research. Compounds that slow aging may prompt the rational design of therapeutics against age-related diseases. Here we evaluate invertebrate models for drug discovery in aging and outline how the field may develop from these simple first steps.

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“…Resistance to oxidative stress is a major factor in longevity determination of nematodes (19)(20)(21)(22), Drosophila (23)(24)(25)(26), and rodents (27). One of the factors in the extension of life span of Snell dwarf mice has been attributed to their resistance to oxidative stress (28)(29)(30).…”

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confidence: 99%

Thioredoxin‐ASK1 complex levels regulate ROS‐mediated p38 MAPK pathway activity in livers of aged and long‐lived Snell dwarf mice

2006

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We have proposed that the age-associated increase of reactive oxygen species (ROS) by electron transport chain (ETC) dysfunction may cause the elevated basal level of p38 MAPK stress response pathway activity. However, the mechanism by which ROS activates this pathway is not clear. Here we propose that activation of the p38 MAPK pathway by complex I (CI) generated ROS, in response to rotenone (ROT) treatment, is based on the ability of reduced Trx to bind to and inhibit ASK 1 and its release from the complex upon oxidation. This balance of free vs. bound ASK1 regulates the level of p38 MAPK pathway activity. To support this mechanism we demonstrate that the production of ROS by ROT treated AML12 hepatocyte cells dissociates the Trx-ASK1 complex, thereby increasing p38 MAPK pathway activity. This mechanism is supported by the ability of N-acetyl cysteine (NAC) to prevent dissociation of Trx-ASK1 and activation of the p38 MAPK pathway. We also demonstrated that the ratio of ASK1/Trx-ASK1 increases in aged mouse livers and that this correlates with the increased basal activity of the p38 MAPK pathway. The longevity of Snell dwarf mice has been attributed to their resistance to oxidative stress. A comparison of the levels of Trx-ASK1 in young and aged dwarfs showed a higher abundance of the complex than in their age-matched controls. These results, which are indicative of a decreased level of oxidative stress, suggest that increased ROS production in aged liver may alter the ratio of ASK1 and Trx-ASK1, thereby increasing the age-associated basal level of p38 MAPK pathway activity.-Hsieh, C.-C., Papaconstantinou, J. Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. Keywordsrotenone; MKK3 kinase; MKP-1 levels; MAPK signaling THE FREE RADICAL THEORY OF AGING proposes that endogenously produced oxygen radicals (ROS) are a basic cause of the progressive age-associated declines in tissue function, and that oxidative stress generated by extrinsic environmental factors accelerate this decline (1-6). Some of the biochemical characteristics of aged tissues are the consequences of an increase in their prooxidant state, and it has been hypothesized that this affects the activity and function of key proteins of signal transduction pathways that regulate stress response (7,8). Specifically, our past studies have shown that the regulation of translation of C/EBPα and C/EBPβ transcription factors and the increased basal levels of activities of p38 MAPK and SAPK/JNK stress response signaling pathways suggest the development of a state of chronic stress in aged tissues (4, NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript 7-13). However, although these studies suggest an interaction between the increased levels of intrinsic oxidative stress and of stress response signal transduction pathway activities, little is known about the mechanism that links these physiological characteristics of aged tissues.It has been shown that...

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Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin

Cited by 99 publications

References 54 publications

Melatonin: a possible link between the presence of artificial light at night and reductions in biological fitness

Melatonin: a possible link between the presence of artificial light at night and reductions in biological fitness

Pharmacological intervention in invertebrate aging

Thioredoxin‐ASK1 complex levels regulate ROS‐mediated p38 MAPK pathway activity in livers of aged and long‐lived Snell dwarf mice

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