2020
DOI: 10.1371/journal.pone.0228443
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Extension of a multiphase tumour growth model to study nanoparticle delivery to solid tumours

Abstract: One of the main challenges in increasing the efficacy of conventional chemotherapeutics is the fact that they do not reach cancerous cells at a sufficiently high dosage. In order to remedy this deficiency, nanoparticle-based drugs have evolved as a promising novel approach to more specific tumour targeting. Nevertheless, several biophysical phenomena prevent the sufficient penetration of nanoparticles in order to target the entire tumour. We therefore extend our vascular multiphase tumour growth model, enablin… Show more

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Cited by 24 publications
(34 citation statements)
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“…The in vivo and in vitro microscopic images of the distribution of cmHsp70.1-AuNP-conjugates within cancer cells [57,69] enabled the setup of cellular compartmental models to estimate the kinetic behavior of AuNPs after in vivo application. To overcome the limits of the model to small animals, continuum models for nanoparticle transport may be successfully applied, such as that reported by Wirthl et al [112]. In that case, larger domains, such as multiphase tumor growth and longer time scales, can be investigated.…”
Section: Discussionmentioning
confidence: 99%
“…The in vivo and in vitro microscopic images of the distribution of cmHsp70.1-AuNP-conjugates within cancer cells [57,69] enabled the setup of cellular compartmental models to estimate the kinetic behavior of AuNPs after in vivo application. To overcome the limits of the model to small animals, continuum models for nanoparticle transport may be successfully applied, such as that reported by Wirthl et al [112]. In that case, larger domains, such as multiphase tumor growth and longer time scales, can be investigated.…”
Section: Discussionmentioning
confidence: 99%
“…However, the approaches illustrated will provide a solid foundation for continuum mechanical modeling of tumor growth. Some previous tumor growth models have included elements of TCAT but not to the extent detailed in this work [32,[53][54][55]60]. They have been successful in modeling tumor growth but not entirely satisfactory.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the inclusion of species transport to simulate drug delivery or nutrient transport lies at hand. Species transport including the coupling between resolved and homogenized vasculature is possible within our hybrid multiphase tumor growth model (Kremheller et al 2019) and we have already studied nanoparticle delivery to solid tumors employing the homogenized compartment only (Wirthl et al 2020). These models could ultimately enhance our understanding of the limitations of current drug delivery strategies and aid in devising more targeted therapies.…”
Section: Discussionmentioning
confidence: 99%