Extending Time Profile of Morphine‐Induced Analgesia Using a Chitosan‐Based Molecular Imprinted Polymer Nanogel

Hassanzadeh, Marjan; Ghaemy, Mousa; Ahmadi, Shamseddin

doi:10.1002/mabi.201600177

Cited by 22 publications

(4 citation statements)

References 53 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 46 Other extended release formulas of morphine, however, such as those produced using nanogels, only resulted in the extension of analgesic effects for approximately 1 h longer than that of free morphine when tested using the hot-plate test in naïve mice. 35 Similarly, NKTR-181, the five-ring morphine-like scaffold bonded to a short-chain PEG produced analgesic-like effects for only up to 4-h post-administration in the hot-plate test in mice, this being similar to the effects of free opioids. 39 …”

Section: Discussionmentioning

confidence: 99%

“…Some of the more commonly used formulations that are available are Embeda®, which contains pellets of morphine sulfate with sequestered naltrexone 34 and Kadian®, which contains polymer coated morphine sulfate pellets. 32 Morphine has also been incorporated into nanogels 35 and liposomes 36 in order to increase the duration of its analgesic effects. The main difference between these formulations and PolyMorphine is that in these compounds, free morphine is sequestered in a polymer coating, whereas in PolyMorphine, free morphine is directly incorporated into a polymer form.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury

Lax

Chen²,

Leep

et al. 2017

Mol Pain

View full text Add to dashboard Cite

Morphine is a well-characterized and effective analgesic commonly used to provide pain relief to patients suffering from both acute and chronic pain conditions. Despite its widespread use and effectiveness, one of the major drawbacks of morphine is its relatively short half-life of approximately 4 h. This short half-life often necessitates multiple administrations of the drug each day, which may contribute to both dependence and tolerance to morphine. Here, we tested the analgesic properties of a new polymer form of morphine known as PolyMorphine. This polymer has monomeric units of morphine incorporated into a poly(anhydride-ester) backbone that has been shown to hydrolyze into free morphine in vitro. Using an animal model of chronic pain, the spared nerve injury surgery, we showed that PolyMorphine is able to block spared nerve injury-induced hypersensitivity in mice for up to 24-h post-administration. Free morphine was shown to only block spared nerve injury-induced hypersensitivity for up to 2-h post-injection. PolyMorphine was also shown to act through the mu opioid receptor due to the ability of naloxone (a mu opioid receptor antagonist) to block PolyMorphine-induced analgesia in spared nerve injury animals pretreated with PolyMorphine. Additionally, we observed that PolyMorphine causes similar locomotor and constipation side effects as free morphine. Finally, we investigated if PolyMorphine had any effects in a non-evoked pain assay, conditioned place preference. Pretreatment of spared nerve injury mice with PolyMorphine blocked the development of conditioned place preference for 2-methyl-6-(phenylethynyl)pyridine (MPEP), a short-lasting mGluR5 antagonist with analgesic-like properties. Free morphine does not block the development of preference for MPEP, suggesting that PolyMorphine has longer lasting analgesic effects compared to free morphine. Together, these data show that PolyMorphine has the potential to provide analgesia for significantly longer than free morphine while likely working through the same receptor.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury

Lax

Chen²,

Leep

et al. 2017

Mol Pain

View full text Add to dashboard Cite

show abstract

“…Molecularly imprinted polymers (MIPs) are attractive synthetic receptors that can speci cally capture the target molecule (Hassanzadeh et al 2016). For preparation of MIPs, the target compound (template) with functional monomer and cross-linker agent are polymerized.…”

Section: Introductionmentioning

confidence: 99%

Simple and selective extraction of quercetin with MEPS method using modified glass powder by a molecularly imprinted polymer followed by spectrophotometric determination

Sharifi

Hallaj

Bahar

2023

Preprint

View full text Add to dashboard Cite

A new sample preparation method based on microextraction in packed syringe (MEPS) was developed for preconcentration of quercetin prior to its spectrophotometric determination. Molecularly imprinted polymers (MIPs) as packing material was used for higher extraction efficiency. First, Glass powder as support material because of low-cost and available substrate were modified and then MIPs synthesized by the sol-gel method using 3 aminopropyltriethoxysilane (APTES) as a functional monomer and tetraethyl orthosilicate (TEOS) as cross-linker. The combination of a molecularly imprinted polymers (MIPs) and microextraction in packed syringe (MEPS) increased the selectivity and sensitivity. The surface morphology and functionality of the prepared MIPs was characterized using Fourier-transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM) and Thermogravimetric analysis (TGA). Different influencing parameters on extraction efficiency such as effect of the number of sample sorption/desorption cycles, type and volume of desorption solvent, pH of the sample solution and MIP amounts were optimized. Under the optimum condition, the proposed method displayed a linear range from 0.01 to 5 μg mL-1 and detection limit of 3.68 ng mL-1. Relative standard deviations (RSD) for 3 replicate determination of 1 μg mL-1 quercetin was 2.1 %. The proposed method was applied successfully for the selective extraction of quercetin from tea and coffee samples.

show abstract

“…Molecularly imprinted polymers (MIPs) are attractive synthetic receptors that can specifically capture the target molecule [18]. For preparation of MIPs, the target compound (template) with functional monomer and cross‐linker agent are polymerized.…”

Section: Introductionmentioning

confidence: 99%

Simple and selective extraction of quercetin with microextraction in packed syringe method using modified glass powder by a molecularly imprinted polymer followed by spectrophotometric determination

Sharifi

Bahar

Hallaj

2023

J of Separation Science

View full text Add to dashboard Cite

A new sample preparation method based on microextraction in packed syringe was developed for preconcentration of quercetin prior to its spectrophotometric determination. Molecularly imprinted polymers as packing material was used for higher extraction efficiency. First, glass powder as support material because of low cost and available substrate was modified, and then molecularly imprinted polymers were synthesized by the sol-gel method using 3-aminopropyltriethoxysilane as a functional monomer and tetraethyl orthosilicate as cross-linker agent. The combination of a molecularly imprinted polymers and microextraction in packed syringe increased the selectivity and sensitivity. The surface morphology and functionality of the prepared molecularly imprinted polymers was characterized using Fourier-transform infrared spectroscopy, Field emission scanning electron microscopy, energy dispersive X-ray spectroscopy, and thermogravimetric analysis. Different influencing parameters on extraction efficiency such as effect of the number of sample sorption/desorption cycles, type and volume of desorption solvent, pH of the sample solution, and molecularly imprinted polymers amounts were optimized. Under the optimum condition, the proposed method displayed a linear range from 0.01 to 5 µg mL −1 and limit of detection 3.68 ng mL −1 . Relative standard deviation for three replicate determination of 1 µg mL −1 quercetin was 2.1 %. The proposed method was applied successfully for the selective extraction of quercetin from tea and coffee samples. K E Y W O R D S glass powder, microextraction in packed syringe, molecularly imprinted polymer, quercetin 1 INTRODUCTION Flavonoids are group of polyphenolic compounds that exhibits biological effects such as anti-oxidative, anti-Abbreviations: APTES, 3-aminopropyltriethoxysilane; MEPS, microextraction in packed syringe; MIP, molecularly imprinted polymer; TEOS, tetraethyl orthosilicate. inflammatory, anti-allergenic, antithrombotic, hepatoprotective, and antiviral activities. They have divided into subclasses of flavones, isoflavones, flavonols, flavanals, flavanones, anthocyanidins, and chalcones [1-3]. Quercetin (flavonol) is one of the most abundant flavonoids present in various foods including vegetables and fruits like black and green tea, cocoa powder, apple, onion, tomato, broccoli, and other leafy green vegetables [4]. Quercetin shows

show abstract

Extending Time Profile of Morphine‐Induced Analgesia Using a Chitosan‐Based Molecular Imprinted Polymer Nanogel

Cited by 22 publications

References 53 publications

PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury

PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury

Simple and selective extraction of quercetin with MEPS method using modified glass powder by a molecularly imprinted polymer followed by spectrophotometric determination

Simple and selective extraction of quercetin with microextraction in packed syringe method using modified glass powder by a molecularly imprinted polymer followed by spectrophotometric determination

Contact Info

Product

Resources

About