Extending the storage of red cells at 4 °C

Meryman, Harold T.; Hornblower, M.; Syring, R. L.; Mesbah-Karimi, Nooshin

doi:10.1016/0955-3886(94)90085-x

Cited by 13 publications

(7 citation statements)

References 19 publications

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“…The metabolomic findings may be the more important because they suggest that RBCs generally maintain their metabolism as well as decreasing pH allows despite the gradual oxidation of their proteins. This is consistent with a demonstration by Meryman et al 7 2 decades ago that RBCs could be stored oxygenated for 9 months at refrigerator temperatures with good recovery if the storage solution was changed regularly to prevent the decline in pH. Metabolic support is the critical function of current RBC storage systems.…”

supporting

confidence: 76%

“…6 Mutations in TSP5 lead to premature assembly of the ECM in the endoplasmic reticulum and cause the human dwarfing condition pseudoachondroplasia. 7 It will be important to determine whether or not the large morphologic changes in collagen RBC storage lesions For personal use only. on May 11, 2018. by guest www.bloodjournal.org From allowed donors to be separated from recipients in space, and nutrient dextrose allowed them to be separated in time.…”

mentioning

confidence: 99%

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RBC storage lesions

Hess

2016

Blood

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supporting

confidence: 76%

mentioning

confidence: 99%

RBC storage lesions

Hess

2016

Blood

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“…The rapid cooling of RBCs after separation and filtration deserves to be included in processing standards. Optimal standards for the collection and storage of transfusible RBCs should consider not only viability but the functional properties associated with adequate levels of 2,3‐DPG and ATP 16 …”

Section: 3‐dpg Atp and Phmentioning

confidence: 99%

Red blood cells intended for transfusion: quality criteria revisited

Högman

Meryman

2005

Transfusion

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Great variation exists with respect to viability and function of fresh and stored red blood cells (RBCs) as well as of the contents of RBC hemoglobin (Hb) in individual units. Improved technology is available for the preparation as well as the storage of RBCs. The authors raise the question whether it may be time to revise current standards for RBC units. The establishment of a standard unit of blood based on Hb content should be a high-priority goal. It is recommended that a standard RBC unit should contain 50 g of Hb. Major organizations concerned with the collection and distribution of blood components should agree on the criteria for a standard unit of RBCs based on Hb content and for the collection of double units. Manufacturers of blood collection equipment should provide suitable technology for collecting a standard unit with defined contents of RBC Hb. Efforts should be directed at the design of storage solutions acceptable for transfusion that maximize the maintenance of both RBC viability and function during storage. The ideal storage protocol would require sterile, high-pH solutions containing both glucose and electrolytes.

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“…50 They went on in 1994 to show that RBCs could be stored in very dilute suspensions for 35 weeks. 51 Such demonstrations show that the 5-to 7-week limits of conventional liquid RBC storage are not a result of anything intrinsic to the RBCs themselves but are a consequence of currently employed methods.…”

Section: Designing Better Rbc Storage Systemsmentioning

confidence: 95%