Extending the Near-Infrared Emission Range of Indium Phosphide Quantum Dots for Multiplexed <i>In Vivo</i> Imaging

Saeboe, Alexander; Nikiforov, A. I.; Toufanian, Reyhaneh; Kays, Joshua; Chern, Margaret; Casas, Jorge Paolo; Han, Keyi; Piryatinski, Andrei; Jones, Dennis; Dennis, Allison M.

doi:10.1021/acs.nanolett.1c00600

Cited by 53 publications

(51 citation statements)

References 59 publications

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“…By introducing HgS interlayer at the core/shell CdSe@CdS QDs interface, the visible emitters can be converted into highly efficient NIR fluorophores by Klimov (Sayevich et al, 2021). Dennis also reported the similar ZnSe@ InP@ZnS core/shell/shell heterostructure, in which tunable emission ranging from visible to NIR wavelengths can be obtained by changing the InP interlayer thickness (Figure 3C; Saeboe et al, 2021). Through well-designed core-shell structure, doping different ions, and surface modification the NIR emissions QDs with biocompatible properties can be achieved.…”

Section: Frontiers Inmentioning

confidence: 96%

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Near-Infrared Inorganic Nanomaterials for Precise Diagnosis and Therapy

Zhang

Liu

2021

Front. Bioeng. Biotechnol.

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Traditional wavelengths (400–700 nm) have made tremendous inroads in vivo fluorescence imaging. However, the ability of visible light photon penetration hampered the bio-applications. With reduced photon scattering, minimal tissue absorption and negligible autofluorescence properties, near-infrared light (NIR 700–1700 nm) demonstrates better resolution, high signal-to-background ratios, and deep tissue penetration capability, which will be of great significance for in-vivo determination in deep tissue. In this review, we summarized the latest novel NIR inorganic nanomaterials and the emission mechanism including single-walled carbon nanotubes, rare-earth nanoparticles, quantum dots, metal nanomaterials. Subsequently, the recent progress of precise noninvasive diagnosis in biomedicine and cancer therapy utilizing near-infrared inorganic nanomaterials are discussed. In addition, this review will highlight the concerns, challenges and future directions of near-infrared light utilization.

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Section: Frontiers Inmentioning

confidence: 96%

“…Reproduced with permission from Bruns et al (2017) . (C) NIR emission ZnSe/InP/ZnS core/shell/shell nanoparticles and their bandgap alignments with corresponding electron and hole wave functions ( Saeboe et al, 2021 ). Reproduced with permission from Dennis et al (2021).…”

Section: Emission Mechanism Of Near-infrared Inorganic Nanomaterialsmentioning

confidence: 99%

Near-Infrared Inorganic Nanomaterials for Precise Diagnosis and Therapy

Zhang

Liu

2021

Front. Bioeng. Biotechnol.

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“…In a mouse model using multiplexed lymph node imaging, Saeboe et al reported the reddest emitting indium phosphide quantum dots (InPQDs) to date. In the first optical tissue window, they exhibited tunable NIR photoluminescence (PL) as well as PL multiplexing while avoiding hazardous components (68). By widening the range of controllable direct-bandgap emission from InP-based nanostructures, these nanoparticles efficiently overcome a synthetic barrier that has stopped InPQDs from reaching their full potential.…”

Section: Qds For In Vivo Imagingmentioning

confidence: 99%

Bio-Conjugated Quantum Dots for Cancer Research: Detection and Imaging

et al. 2021

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Ultrasound, computed tomography, magnetic resonance, and gamma scintigraphy-based detection and bio-imaging technologies have achieved outstanding breakthroughs in recent years. However, these technologies still encounter several limitations such as insufficient sensitivity, specificity and security that limit their applications in cancer detection and bio-imaging. The semiconductor quantum dots (QDs) are a kind of newly developed fluorescent nanoparticles that have superior fluorescence intensity, strong resistance to photo-bleaching, size-tunable light emission and could produce multiple fluorescent colors under single-source excitation. Furthermore, QDs have optimal surface to link with multiple targets such as antibodies, peptides, and several other small molecules. Thus, QDs might serve as potential, more sensitive and specific methods of detection than conventional methods applied in cancer molecular targeting and bio-imaging. However, many challenges such as cytotoxicity and nonspecific uptake still exist limiting their wider applications. In the present review, we aim to summarize the current applications and challenges of QDs in cancer research mainly focusing on tumor detection, bio-imaging, and provides opinions on how to address these challenges.

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“…example, in a recent study, Saeboe et al performed multiplexed in vivo imaging in NIR-I using ZnSe/InP/ZnS SNCs (Figure5 -B) 55. The clever core/multi-shell architecture and the resulting band scheme induced localization of the electron's wavefunction at the ZnSe core and the holes at the first InP shell, in turn pushing the emission of InP deeper into the NIR (Figure5-B1).…”

mentioning

confidence: 97%