Extending the Duration of Tear Film Protection in Dry Eye Syndrome: Review and Retrospective Case Series Study of the Hydroxypropyl Cellulose Ophthalmic Insert

Wander, Arden H.; Koffler, Bruce H.

doi:10.1016/s1542-0124(12)70310-5

Cited by 21 publications

(9 citation statements)

References 18 publications

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“…43 LacrisertÒ (Aton Pharmaceuticals, Lawrenceville, NJ) is a 5 mg insert of preservative-free hydroxypropyl cellulose. The insert is placed in the inferior cul-de-sac and dissolves at body temperature, thickening the tear film.…”

Section: Management Of Dry Eyementioning

confidence: 99%

Clinical Guidelines for Management of Dry Eye Associated with Sjögren Disease

et al. 2015

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Section: Management Of Dry Eyementioning

confidence: 99%

Clinical Guidelines for Management of Dry Eye Associated with Sjögren Disease

et al. 2015

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“…Hydroxypropyl cellulose ophthalmic inserts are indicated for patients with moderate-to-severe dry eye. Because the formulation is preservative free, it may help patients who are not able or willing to use artificial tears on a frequent basis [96,97]. Published clinical evidence of efficacy (level II) has reported a significant improvement in tear deficiency symptoms and OSDI scores with once-daily use of hydroxypropyl cellulose ophthalmic inserts [98,99].…”

Section: Treatment Options For Dysfunctional Tear Syndromementioning

confidence: 99%

Dysfunctional tear syndrome

Milner

Beckman

Luchs

et al. 2017

Current Opinion in Ophthalmology

161

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Dysfunctional tear syndrome (DTS) is a common and complex condition affecting the ocular surface. The health and normal functioning of the ocular surface is dependent on a stable and sufficient tear film. Clinician awareness of conditions affecting the ocular surface has increased in recent years because of expanded research and the publication of diagnosis and treatment guidelines pertaining to disorders resulting in DTS, including the Delphi panel treatment recommendations for DTS (2006), the International Dry Eye Workshop (DEWS) (2007), the Meibomian Gland Dysfunction (MGD) Workshop (2011), and the updated Preferred Practice Pattern guidelines from the American Academy of Ophthalmology pertaining to dry eye and blepharitis (2013). Since the publication of the existing guidelines, new diagnostic techniques and treatment options that provide an opportunity for better management of patients have become available. Clinicians are now able to access a wealth of information that can help them obtain a differential diagnosis and treatment approach for patients presenting with DTS. This review provides a practical and directed approach to the diagnosis and treatment of patients with DTS, emphasizing treatment that is tailored to the specific disease subtype as well as the severity of the condition.

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“…28,39 Long-term use of the inserts in patients with dry eye is also supported by data from a recent retrospective case series study. 40 Of the 80 patients included in the study, 65% had used the inserts for more than 2 years, and the median duration of therapy was 5.3 years. Of patients with keratitis, grittiness, dryness, and burning or stinging before use, 97%, 87%, 80%, and 90% responded to treatment, respectively.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Use of Hydroxypropyl Cellulose Ophthalmic Insert to Relieve Symptoms of Dry Eye in a Contact Lens Wearer: Case-Based Experience

Wander

2011

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Dry eye is a chronic disease often requiring long-term management. In this case, daily use of hydroxypropyl cellulose ophthalmic inserts effectively treated autoimmune dry eye, providing symptomatic relief, and resulted in improved objective measures of disease severity across several decades. Such an experience is consistent with the available evidence-based data for hydroxypropyl cellulose ophthalmic inserts and supports their use in clinical practice for the treatment of moderate-to-severe dry eye disease.

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Extending the Duration of Tear Film Protection in Dry Eye Syndrome: Review and Retrospective Case Series Study of the Hydroxypropyl Cellulose Ophthalmic Insert

Cited by 21 publications

References 18 publications

Clinical Guidelines for Management of Dry Eye Associated with Sjögren Disease

Clinical Guidelines for Management of Dry Eye Associated with Sjögren Disease

Dysfunctional tear syndrome

Long-Term Use of Hydroxypropyl Cellulose Ophthalmic Insert to Relieve Symptoms of Dry Eye in a Contact Lens Wearer: Case-Based Experience

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