We present a study of reddening and absorption towards the Narrow Line Regions (NLR) in active galactic nuclei (AGN) selected from the Revised Shapley-Ames, 12µm, and Swift/Burst Alert Telescope samples. For the sources in host galaxies with inclinations of b/a > 0.5, we find that mean ratio of [O III] λ5007, from ground-based observations, and [O IV] 28.59µm, from Spitzer/Infrared Spectrograph observations, is a factor of 2 lower in Seyfert 2s than Seyfert 1s. The combination of low [O III]/[O IV] and [O III] λ4363/λ5007 ratios in Seyfert 2s suggests more extinction of emission from the NLR than in Seyfert 1s. Similar column densities of dusty gas, N H ∼ several × 10 21 cm −2 , can account for the suppression of both [O III] λ5007 and [O III] λ4363, as compared to those observed in Seyfert 1s. Also, we find that the X-ray line O VII λ22.1Å is weaker in Seyfert 2s, consistent with absorption by the same gas that reddens the optical emission. Using a Hubble Space Telescope/Space Telescope Imaging Spectrograph slitless spectrum of the Seyfert 1 galaxy NGC 4151, we estimate that only ∼ 30% of the [O III] λ5007 comes from within 30 pc of the central source, which is insufficient to account for the low [O III]/[O IV] ratios in Seyfert