Extended Temporal Bone Resection for Squamous Cell Carcinoma

Moffat, David A.; Grey, Philip; Ballagh, Robert H.; Hardy, David G.

doi:10.1016/s0194-5998(97)70237-7

Cited by 51 publications

(44 citation statements)

References 23 publications

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“…The extant literature consists of numerous case series that have reported a wide range of survival data, reflecting differences in the underlying characteristics of cohorts drawn from various institutions. 1,6,[8][9][10][12][13][14][15]18,19,22,24,[30][31][32][33][34][35][36][37][38][39][40][41] Historical survival data can be most readily generalized to clinical practice if factors predictive of outcome can be identified. Several larger series have reported preliminary descriptions of factors influencing survival, based on univariate comparisons.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

et al. 2011

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Background. The purpose of this study was to identify factors predictive of outcome in patients undergoing temporal bone resection (TBR) for head and neck cancer.Methods. This was a retrospective study of 72 patients undergoing TBR. Factors associated with survival and recurrence were identified on multivariable regression. Results. Most tumors were epithelial (81%), commonly (69%) involving critical structures. Cervical metastases were uncommon (6%). Squamous cell carcinoma (SCC) of the external auditory canal carried a high rate of parotid invasion (25%) and parotid nodal metastases (43%).The 5-year rate of overall survival (OS) was 62%; disease-specific survival (DSS), 70%; recurrence-free survival (RFS), 46%. Factors independently associated with outcome on multivariable analysis were margin status and extratemporal spread of disease to the parotid, mandible, or regional nodes. Recurrence was common (72%) in cT3-4 tumors. Conclusions. Margin status and extratemporal disease spread are the strongest independent predictors of survival and recurrence. In SCC of the external auditory canal, high rates of parotid involvement support adjunctive parotidectomy. Risk of recurrence in T3-T4 tumors may support a role for adjuvant therapy.

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Section: Discussionmentioning

confidence: 99%

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

et al. 2011

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“…The use of radiotherapy alone has been considered, although its benefit may be limited by poor bone penetration and concomitant infection. 22 Combination therapy with both surgery and adjuvant radiotherapy is therefore often preferred.…”

Section: Discussionmentioning

confidence: 99%

Primary middle ear Epstein‐Barr virus‐related lymphoepithelial carcinoma: Case reports and systematic review

2009

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Objectives/Hypothesis: To report two cases of primary lymphoepithelial carcinoma in the middle ear and to determine the optimal treatment for such lesions.Study Design/Methods: Case reports and a systematic review of the literature.Results: Primary lymphoepithelial carcinoma in the middle ear is an exceptionally rare condition with only two other cases reported in the literature. There appears to be an association with Epstein-Barr virus infection and in those patients originating from the Guangdong province of China, much as is the case for similar lesions found in the nasopharynx. Piecemeal rather than en bloc excision, in combination with adjuvant radiotherapy, appears to adequately control the disease.Conclusions: Primary lymphoepithelial carcinoma of the middle ear is a rare lesion, which when treated has a good prognosis.

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“…In a retrospective analysis of 15 patients with EAM carcinoma, Ussmuller et al [3] described osseous destruction in more than 90% of the cases. Neck lymph nodes are not usually involved [4,5]. Tumours that violate the middle ear or mastoid cavities, or violate the medial layer of the tympanic membrane, require subtotal or extended resection of the temporal bone.…”

Section: Discussionmentioning

confidence: 99%

Spindle cell carcinoma of the external auditory meatus with intracranial extension: histological, immunohistochemical and electron microscopic evaluation

Quaranta¹,

Berardi²,

Piscitelli³

et al. 2007

Acta Oto-Laryngologica

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We present a case of squamous spindle cell carcinoma of the external auditory meatus in a 38-year-old man. The tumour was extended to the inner ear, the temporal bone, the middle cranial fossa and the meningo-cerebral tissue. The surgical intervention of temporo-occipital craniotomy removed most of the neoplasia. At pathologic examination, the tumour showed an undifferentiated spindle cell pattern. Immunohistochemistry with a large antibody panel found a weak positivity only to EMA. The diagnosis was made when the electron microscopy showed rare junctional structures and tonofilaments.

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Extended Temporal Bone Resection for Squamous Cell Carcinoma

Cited by 51 publications

References 23 publications

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

Predictors of Survival and Recurrence after Temporal Bone Resection for Cancer

Primary middle ear Epstein‐Barr virus‐related lymphoepithelial carcinoma: Case reports and systematic review

Spindle cell carcinoma of the external auditory meatus with intracranial extension: histological, immunohistochemical and electron microscopic evaluation

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