Extended tacrolimus release via the combination of lipid-based solid dispersion and HPMC hydrogel matrix tablets

Xu, Huaizhe; Liu, Li; Li, Xuehui; Ma, Junyuan; Li, Rui; Wang, Shaoning

doi:10.1016/j.ajps.2018.08.001

Cited by 27 publications

(13 citation statements)

References 36 publications

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“…The solid lipid NPs (SLNs) was first prepared in 1990s as potential substitute drug carriers of polymeric NPs, emulsions and liposomes. Their composition which is devoid of organic solvents make them attractive candidate as a drug delivery system 94 , 95 , 96 . They are mostly spherical particles with size up to 1000 nm.…”

Section: Np-based Dds For Ambmentioning

confidence: 99%

Delivery strategies of amphotericin B for invasive fungal infections

Wang

Mohammad

Fan

et al. 2021

Acta Pharmaceutica Sinica B

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Invasive fungal infections (IFIs) represent a growing public concern for clinicians to manage in many medical settings, with substantial associated morbidities and mortalities. Among many current therapeutic options for the treatment of IFIs, amphotericin B (AmB) is the most frequently used drug. AmB is considered as a first-line drug in the clinic that has strong antifungal activity and less resistance. In this review, we summarized the most promising research efforts on nanocarriers for AmB delivery and highlighted their efficacy and safety for treating IFIs. We have also discussed the mechanism of actions of AmB, rationale for treating IFIs, and recent advances in formulating AmB for clinical use. Finally, this review discusses some practical considerations and provides recommendations for future studies in applying AmB for combating IFIs.

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Section: Np-based Dds For Ambmentioning

confidence: 99%

Delivery strategies of amphotericin B for invasive fungal infections

Wang

Mohammad

Fan

et al. 2021

Acta Pharmaceutica Sinica B

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“…The polymeric carriers can be synthetic or natural polymers. Synthetic polymers include povidone (PVP) [46,47,48,49,50], PEG [51,52,53,54], and polymethacrylates [55,56], and natural polymers include hydroxypropylmethylcellulose (HPMC) [57,58,59,60,61], ethyl cellulose [62,63,64], and starch derivatives such as cyclodextrins (CDs) [65]. A study by Franco et al [66] showed that using PVP as a carrier in ketoprofen SD increased the dissolution rate of ketoprofen 4.2-fold compared to that of the conventional drug.…”

Section: Solid Dispersionsmentioning

confidence: 99%

Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs

et al. 2019

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Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic drugs (monoclonal antibodies) and small molecule drugs (nonbiologic anticancer drugs) based on effectiveness and safety profile. Biologic drugs are administered by intravenous (IV) injection due to their large molecular weight, while small molecule drugs are preferentially administered by gastrointestinal route. Even though IV injection is the fastest route of administration and ensures complete bioavailability, this route of administration causes patient inconvenience to visit a hospital for anticancer treatments. In addition, IV administration can cause several side effects such as severe hypersensitivity, myelosuppression, neutropenia, and neurotoxicity. Oral administration is the preferred route for drug delivery due to several advantages such as low cost, pain avoidance, and safety. The main problem of NCEs is a limited aqueous solubility, resulting in poor absorption and low bioavailability. Therefore, improving oral bioavailability of poorly water-soluble drugs is a great challenge in the development of pharmaceutical dosage forms. Several methods such as solid dispersion, complexation, lipid-based systems, micronization, nanonization, and co-crystals were developed to improve the solubility of hydrophobic drugs. Recently, solid dispersion is one of the most widely used and successful techniques in formulation development. This review mainly discusses classification, methods for preparation of solid dispersions, and use of solid dispersion for improving solubility of poorly soluble anticancer drugs.

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“…These polymeric carriers comprised synthetic polymers such as povidone, polyethylene glycol (PEG), and polymethacrylates, [19][20][21] as well as natural polymers such as hydroxypropyl methylcellulose (HPMC), ethyl cellulose, and starch derivatives such as cyclodextrin. [22][23][24] Recently, a third class of SDs has been prepared using surfactants either alone or in amalgamation with other hydrophilic carriers. The surfactant adsorbs itself onto the solid surface of the hydrophobic drug, causing a decrease in surface tension and increase in solubility of the drug.…”

Section: Carrier-based Sdsmentioning

confidence: 99%

Solid Dispersion: A Mechanistic and Realistic Approach on Antihypertensive Drug as a Drug Carrier System

Swarup

Agrawal

2021

ASSAY and Drug Development Technologies

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A major percentage of the new chemical entities are reported to have poor aqueous solubility. Several antihypertensive drugs used clinically have either low solubility or high hepatic metabolism, thereby presenting low bioavailability (BA) and high pharmacokinetic variability. Improving the aqueous solubility of drug molecules would assist in overcoming the variability, and several approaches for improving solubility have been reported. Solid dispersion (SD) is known as a potential technique to conquer the problem of poor aqueous solubility and low BA. Drug solubility is improved by increasing the wetting property of drugs. This review is focused on discussing various approaches to improve solubility, classification, and different approaches used for formulation of SDs, along with special emphasis on the application of the SD approach for improving solubility and eventually enhancing dissolution and increasing the BA of antihypertensive drugs. The review leads to the conclusion that the use of more than one polymeric carrier for formulating SDs might help in overcoming storage and stability issues and in increasing the commercial viability and success of SDs.

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Extended tacrolimus release via the combination of lipid-based solid dispersion and HPMC hydrogel matrix tablets

Cited by 27 publications

References 36 publications

Delivery strategies of amphotericin B for invasive fungal infections

Delivery strategies of amphotericin B for invasive fungal infections

Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs

Solid Dispersion: A Mechanistic and Realistic Approach on Antihypertensive Drug as a Drug Carrier System

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