Extended-spectrum β-lactamases and AmpC β-lactamases in ceftiofur-resistant Salmonella enterica isolates from food and livestock obtained in Germany during 2003–07

Rodríguez, Irene; Barownick, W.; Helmuth, Reiner; Mendoza, M. C.; Rodicio, M. Rosario; Schroeter, Andreas; Guerra, Beatriz

doi:10.1093/jac/dkp195

Cited by 126 publications

(91 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the AmpC-type β-lactamases, bla CMY-2 is the most common, while bla ACC-1 and bla DHA-1 have only been scarcely reported Carattoli, 2008;Coque et al, 2008a;Cortes et al, 2010;Dierikx et al, 2010a;Hasman et al, 2005;Rayamajhi et al, 2010;Rayamajhi et al, 2008;Rodriguez et al, 2009). Noteworthy, whereas ESBL producers have been mostly found in Europe, AmpC producers have been mostly encountered in the US, mirroring the trends observed among human isolates.…”

Section: Esbl And/or Ampc Encoding Resistance Genesmentioning

confidence: 91%

“…ESBLs of the SHV class were frequently detected throughout the EU, especially SHV-12 and SHV-2 Bortolaia et al, 2010b;Boyle et al, 2010;Brinas et al, 2003a;Brinas et al, 2003b;Chiaretto et al, 2008;Cortes et al, 2010;Costa et al, 2009;Dierikx et al, 2010a;Doi et al, 2009;Escudero et al, 2010;Goncalves et al, 2010;Hasman et al, 2005;Hopkins et al, 2006;Kolar et al, 2010;Machado et al, 2008;Madec et al, 2008;Morris et al, 2009;Riano et al, 2006). In relation to the ESBLs of the TEM class, the most frequently detected throughout the EU was TEM-52 Brinas et al, 2005;Carneiro et al, 2010;Cloeckaert et al, 2007;Costa et al, 2009;Dierikx et al, 2010a;Jensen et al, 2006;Machado et al, 2008;Morris et al, 2009;Randall et al, 2011;Rodriguez et al, 2009;Smet et al, 2008). To a lesser extend TEM-20 was detected in countries as Netherlands, Ireland and Germany (Boyle et al, 2010;Dierikx et al, 2010a;Hasman et al, 2005;Hopkins et al, 2006;Rodriguez et al, 2009).…”

Section: Esbl-subtypes Detected In E Coli and Salmonella From Food-pmentioning

confidence: 99%

“…TEM, SHV, CTX-M) and AmpC (e.g. CMY, DHA-1, ACT-1)-producing organisms have been detected in a variety of food-producing animals (poultry, swine, bovine, horse, rabbit, ostrich, wild boars), and food of animal origin Carattoli, 2008;Carneiro et al, 2010;Cortes et al, 2010;Dierikx et al, 2010a;Escudero et al, 2010;Hunter et al, 2010;Poeta et al, 2009;Rodriguez et al, 2009;Vo et al, 2007). From these hosts, the species more commonly identified have been E. coli and non-typhoidal salmonellae and to a lesser extent, Klebsiella pneumoniae, Citrobacter freundii or Enterobacter spp.…”

Section: 2mentioning

confidence: 99%

“…CTX-M-2 was observed in Central and Northern European countries, including UK and Ireland (Bertrand et al, 2006;Bortolaia et al, 2010a;Boyle et al, 2010;Cloeckaert et al, 2007;Dhanji et al, 2010;Dierikx et al, 2010a;Hasman et al, 2005;Hopkins et al, 2006;Liebana et al, 2006;Morris et al, 2009;Randall et al, 2011;Smet et al, 2008;Warren et al, 2008). CTX-M-15, the ESBL considered to have spread in a pandemic fashion in humans, was only detected incidentally in food-producing animals or food and in only in a few countries in E. coli (isolated in France from diseased cattle, in Belgium from healthy poultry, and in UK in broiler chickens and turkey) and in Salmonella isolates (Germany, one S. Typhimurium from horse origin) (Madec et al, 2008;Randall et al, 2011;Rodriguez et al, 2009;Smet et al, 2008). ESBLs of the SHV class were frequently detected throughout the EU, especially SHV-12 and SHV-2 Bortolaia et al, 2010b;Boyle et al, 2010;Brinas et al, 2003a;Brinas et al, 2003b;Chiaretto et al, 2008;Cortes et al, 2010;Costa et al, 2009;Dierikx et al, 2010a;Doi et al, 2009;Escudero et al, 2010;Goncalves et al, 2010;Hasman et al, 2005;Hopkins et al, 2006;Kolar et al, 2010;Machado et al, 2008;Madec et al, 2008;Morris et al, 2009;Riano et al, 2006).…”

Section: Esbl-subtypes Detected In E Coli and Salmonella From Food-pmentioning

confidence: 99%

See 3 more Smart Citations

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

2011

EFSA Journal

240

View full text Add to dashboard Cite

The potential contribution of food-producing animals or foods to public health risks by ESBL and/or AmpCproducing bacteria is related to specific plasmid-mediated ESBL and/or AmpC genes encoded by a number of organisms. The predominant ESBL families encountered are CTX-M, TEM, and SHV; the predominant AmpCfamily is CMY. The most common genes associated with this resistance in animals are bla CTX-M-1 (the most commonly identified ESBL), and bla CTX-M-14 , followed by bla and bla Among the genes encoding AmpC-type β-lactamases, bla CMY-2 is the most common.The bacterial species most commonly identified with these genes are Escherichia coli and non-typhoidal Salmonella. ESBL/AmpC transmission is mainly driven by integrons, insertion sequences, transposons and plasmids, some of which are homologous in isolates from both food-production animals and humans. Cefotaxime is used as the drug of choice for optimum detection of bla ESBL and/or bla AmpC genes. The preferred method for isolation of ESBL-and/or AmpC-producers is screening on selective agar preceded by selective enrichment in a broth.The establishment of risk factors for occurrence of ESBL/AmpC-producing bacteria is particularly complicated by the data unavailability or lack of its accuracy. The use of antimicrobials is a risk factor for the selection and spread of resistant clones, resistance genes and plasmids. Since most ESBL-and AmpC-producing strains carry additional resistances to other commonly-used veterinary drugs, generic antimicrobial use is a risk factor for ESBL/AmpC and it is not restricted specifically to the use of cephalosporins. An additional risk factor is extensive trade of animals in EU MS. There are no data on the comparative efficiency of individual control options in reducing public health risks caused by ESBL and/or AmpC-producing bacteria related to food-producing animals. Prioritisation is complex, but it is considered that a highly effective control option would be to stop all uses of cephalosporins/systemically active 3 rd /4 th generation cephalosporins, or to restrict their use (use only allowed under specific circumstances). As co-resistance is an important issue, it is also of high priority to decrease the total antimicrobial use in animal production in the EU. KEY WORDSResistance, ESBLs, AmpC, occurrence, transmission, control options, public health microbiology. SUMMARYFollowing a request from the European Commission, the Panel on Biological Hazards (BIOHAZ) was asked to deliver a Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum beta (β)-lactamases (ESBL) and/or AmpC β-lactamases (AmpC) in food and foodproducing animals. In particular, the Panel was asked: (i) to propose a definition of the ESBL-and/or AmpC-producing bacterial strains and genes relevant for public health and linked to food-producing animals or food borne transmission; (ii) to review the information on the epidemiology of acquired resistance to broad spectrum cephalosporins including the genes coding for ...

show abstract

Section: Esbl And/or Ampc Encoding Resistance Genesmentioning

confidence: 91%

Section: Esbl-subtypes Detected In E Coli and Salmonella From Food-pmentioning

confidence: 99%

Section: 2mentioning

confidence: 99%

Section: Esbl-subtypes Detected In E Coli and Salmonella From Food-pmentioning

confidence: 99%

See 2 more Smart Citations

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

2011

EFSA Journal

240

View full text Add to dashboard Cite

show abstract

“…ESBL-/AmpC-producing organisms have been detected in a variety of food-producing animals, mainly poultry and cattle (but also swine, horse, rabbit, ostrich, wild boars), and food of animal origin Vo et al, 2007;Carattoli, 2008;Poeta et al, 2009;Rodriguez et al, 2009;Carneiro et al, 2010;Cortes et al, 2010;Dierikx et al, 2010;Escudero et al, 2010;Hunter et al, 2010) in many European countries. From these hosts, the species more commonly identified have been Ecoli and non-typhoidal salmonellae.…”

Section: Introductionmentioning

confidence: 99%

Technical specifications on harmonised epidemiological indicators for biological hazards to be covered by meat inspection of poultry

2012

EFS2

View full text Add to dashboard Cite

In this report, harmonised epidemiological indicators are proposed for food-borne biological hazards to public health that are related to poultry and meat thereof and that can be addressed within meat inspection. These hazards include Salmonella, Campylobacter and extended-spectrum/AmpC beta-lactamase producing Escherichia coli as well as generic E. coli as an indicator for process hygiene. An epidemiological indicator is defined as the prevalence or concentration of the hazard at a certain stage of the food chain or an indirect measure of the hazard that correlates to human health risk caused by the hazard. The indicators can be used by the European Commission and the Member States to consider when adaptations in meat inspection methods may be relevant and to carry out risk analysis to support such decisions. It is foreseen that the indicators will be used in the integrated food safety assurance system for poultry meat outlined in the EFSA Scientific Opinion, particularly to help categorise farms/flock and slaughterhouses according to the risk related to the hazards and process hygiene as well as setting appropriate targets. Depending on the purpose and the epidemiological situation, risk managers should decide on the most appropriate indicator(s) to use, either alone or in combination, at national, regional, slaughterhouse or farm/flock level. It is recommended that risk managers should define the harmonised requirements for the controlled housing conditions of farms and the requirements for food chain information. Member States are invited to organise training regarding the implementation of the indicators and the reporting of data generated by the implementation in accordance with Directive 2003/99/EC. The proposed indicators should be regularly reviewed in light of new information and the data generated by their implementation.

show abstract

Non-typhoidal Salmonellosis

2013

View full text Add to dashboard Cite

Extended-spectrum β-lactamases and AmpC β-lactamases in ceftiofur-resistant Salmonella enterica isolates from food and livestock obtained in Germany during 2003–07

Cited by 126 publications

References 44 publications

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

Technical specifications on harmonised epidemiological indicators for biological hazards to be covered by meat inspection of poultry

Non-typhoidal Salmonellosis

Contact Info

Product

Resources

About