Extended-spectrum β-lactamases

Larson, Laura; Ramphal, Reuben

doi:10.1053/srin.2002.34687

Cited by 15 publications

(4 citation statements)

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“…In Salmonella , β‐lactamase resistance is often conferred by the presence of the bla TEM or bla PSE gene (Randall et al 2004). Of these, the bla TEM‐1 gene, which is generally plasmid mediated (Larson and Ramphal 2002) is considered the most frequently expressed β‐lactamase in Salmonella in Europe (Guerri et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Transfer of ampicillin resistance from Salmonella Typhimurium DT104 to Escherichia coli K12 in food

Walsh

Duffy

Nally

et al. 2007

Letters in Applied Microbiology

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Aims: To investigate the transfer of antibiotic resistance from a donor Salmonella Typhimurium DT104 strain to a recipient Escherichia coli K12 strain. Methods and Results: Mating experiments were conducted in broth, milk and ground meat (beef) at incubation temperatures of 4, 15, 25 and 37°C for 18 and 36 h. Ampicillin‐resistance transfer was observed at similar frequencies in all transfer media at 25 and 37°C (10−4 to 10−5 log10 CFU ml g−1, transconjugants per recipient) for 18 h. At 15°C, transfer was observed in ground meat in the recipient strain (10−6, log10 CFU g−1, transconjugants per recipient), but not in broth or milk. At 4°C, transfer did not occur in any of the examined mediums. Further analysis of the E. coli K12 nalR transconjugant strain revealed the presence of a newly acquired plasmid (21 kbp) bearing the β‐lactamase gene blaTEM. Transconjugants isolated on the basis of resistance to ampicillin did not acquire any other resistant markers. Conclusion: This study demonstrates the transfer of antibiotic resistance in food matrices at mid‐range temperatures. Significance and Impact of the Study: It highlights the involvement of food matrices in the dissemination of antibiotic‐resistant genes and the evolution of antibiotic‐resistant bacteria.

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Section: Introductionmentioning

confidence: 99%

Transfer of ampicillin resistance from Salmonella Typhimurium DT104 to Escherichia coli K12 in food

Walsh

Duffy

Nally

et al. 2007

Letters in Applied Microbiology

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“…It is also a part of normal skin flora of humans but can cause life threatening opportunistic infections specially in immunocompromised hosts [1]. It has been implicated in diverse group of infections such as otitis externa, burn wounds, decubitus ulcers, cystic fibrosis, urinary tract infections, ventilator associated pneumonia (VAP) and septicemia specially in neutropenic and transplant patients.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Efficacy of Cefepime Against Multi-Drug Resistant Pseudomonas aeruginosa � An Alarming Situation in our Setup

Satti¹,

Abbasi²,

Qumar³

et al. 2011

Open Drug R J

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Abstract:Background: Third generation cephalosporins are still most commonly used antibiotics empirically in our setup leading to emergence of resistance in this group. In this environment of increasing resistance, empirical use of this group of antibiotics would be a futile effort. Therefore, this study was conducted to evaluate the in vitro efficacy of fourth generation cephalosporin cefepime against multi-drug resistant isolates of Pseudomonas aeruginosa from various clinical specimens in our setup. Methodology: All the clinical specimens giving growth of Pseudomonas aeruginosa were included in the study. Modified Kirby-Bauer disk diffusion method was used for sensitivity testing. Isolates resistant to three or more than three groups of antibiotics were included in the final results. Place and Duration of Results:A total of 100 multi-drug resistant Pseudomonas aeruginosa isolates were cultured from various clinical specimens. Out of 100 isolates, 71% were resistant to cefepime while resistance rate of amikacin, gentamicin, ceftazidime, tazobactem/piperacillin, sulbactam/piperacillin, imipenem and polymyxin were 61%, 83%, 72%, 10%, 2%, 45% and 2% respectively. Conclusion:Drug resistance in Pseudomonas aeruginosa is alarming as it is now increasing even in newer generation of drugs. It is the need of hour to follow strict hospital infection control and antibiotic policies to halt the spread of this resistance.

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“…was the most hospital contaminant bacterial species (30% of all isolated strains) as it consists one of four HAIs microorganisms most frequently isolated in the European Union (20). This bacterium is an opportunistic pathogen that can be found in water distribution systems, water containers and as normal flora on the human skin (21). Its ability to survive and spread in hospital environment partly is due to acquisition resistance to commonly used antibiotics and disinfectants (22).These facts makes this species a major life-threatening agent that difficult to avoid in hospitals and was responsible for many outbreaks in different countries (23)(24)(25).…”

Section: Methodsmentioning

confidence: 99%

Analysis Of Routine Bacterial Contamination Checking Feedback Of Nasiriyah City Hospitals During 2016

2019

University of Thi-Qar Journal of Medicine

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Hospital contamination is an important cause of nosocomial infection. This study aims to assess the occurrence of bacterial contamination in 70 different departments of two private and five public hospitals in Nasseriah city (south of Iraq) during 2016. From 50 to 200 swabs collected weekly from each wards, were isolated 213 positive culture bacterial isolates, comprised 11 bacterial species detected by biochemical and enzymatic tests. The contamination was ranged between Pseudomonas species that represent the most contaminant species (30%) to Micrococcus spp. and Citrobacters pp were the fewest (0.46%). Generally, the private hospitals were less contaminated than public ones, the winter and summer months were less contaminated than spring and autumn, and multispecialty hospital have more contamination than single-specialty one.

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Extended-spectrum β-lactamases

Cited by 15 publications

References 0 publications

Transfer of ampicillin resistance from Salmonella Typhimurium DT104 to Escherichia coli K12 in food

Transfer of ampicillin resistance from Salmonella Typhimurium DT104 to Escherichia coli K12 in food

In Vitro Efficacy of Cefepime Against Multi-Drug Resistant Pseudomonas aeruginosa � An Alarming Situation in our Setup

Analysis Of Routine Bacterial Contamination Checking Feedback Of Nasiriyah City Hospitals During 2016

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