Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae Causing Community-Acquired Urinary Tract Infections in Children in Colombia

Camacho-Cruz, Jhon; Martinez, Javier Munoz; Cufino, Julio Mahecha; Moreno, Germán Camacho; Murillo, Carolina Rivera; Fuentes, Maria Alejandra Suarez; Castro, Carlos A.

doi:10.1007/s13312-021-2131-8

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…2 Several studies have also demonstrated that the family Enterobacteriaceae, particularly extended-spectrum beta-lactamase forming E. coli are the most common pathogens of UTIs in adults as well as pediatrics. 3,4 Empiric antimicrobial selection has become challenging in the clinical setting due to the misuse of unprescribed antibiotics, thus proper public education on UTIs and related antibiotics resistance have become important factors that are need to be explored. 5 Despite Sri Lanka is already known as a hotspot of chronic kidney disease of unknown origin (CKDu), Kurunegala district has been identified as a hub of CKDu in the country, where about 10.1% of households from the district are reported to have at least one family member that has been diagnosed with chronic kidney disease.…”

Section: Introductionmentioning

confidence: 99%

Degree of awareness and practices on urinary tract infections: A study of Sri Lankan school teachers selected from a chronic kidney disease high-prevalent setting

Safwan,

Dias,

Dilhari

2024

Urologia

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Objective: As key stakeholders in educational settings, teachers’ awareness on Urinary Tract Infections (UTI) will ultimately enhance its management in schools and community. This study aimed to assess the level of knowledge, attitudes, and practices (KAP) on UTIs among teachers in Sri Lanka. Materials and methods: Conveniently selected 373 school teachers were assessed using a pre-tested questionnaire. Each of the individual was scored and categorized as either satisfactory or poor. Descriptive statistics and chi-square tests were performed to describe the outcomes. Results: Around 80% of respondents demonstrated awareness regarding the microbial origin of UTIs, while 42% possessed knowledge of women’s increased susceptibility to UTIs. Over 90% of participants had favorable attitudes toward drinking adequate amounts of water, personal hygiene, and consulting doctors for UTI symptoms. Each inquiry demonstrated significant disparities between individuals with satisfactory and poor attitudes ( p = 0.000), with over 95% adhered to effective hygiene practices as a preventive measure against UTIs. The demographics of the participants did not show any significance over the KAP results of the study ( p < 0.05). Conclusions: The study revealed satisfactory levels of awareness and favorable attitudes among respondents on UTIs. However, there is a further need for increased awareness, specifically regarding the risk factors associated with UTIs.

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Section: Introductionmentioning

confidence: 99%

Degree of awareness and practices on urinary tract infections: A study of Sri Lankan school teachers selected from a chronic kidney disease high-prevalent setting

Safwan,

Dias,

Dilhari

2024

Urologia

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“…Infancy, delay in starting treatment, recurrences and vesico-ureteric reflux (VUR) are risk factors for renal scarring 6,7,8 . South India ESBL UTI was reported in 40% of the population and among this Escherichia coli and Klebsiella were 46.3% and 25%, respectively 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, high levels of antimicrobial resistance related to ESBL producing Enterobacteriaceae complicate individual patient care, increasing the mortality and morbidity associated with common infectious diseases in children like UTI 9 . ESBL infections in children are associated with longer hospital stays, frequent complications, and increased mortality at higher than adult rates in certain regions 6 . Infancy, children on uroprophylaxis, recent antibiotic usage, recurrent urinary tract infections (UTI), urinary tract anomalies, non-renal comorbidities and male gender should guide antibiotic therapy pending culture results in ESBL UTI children 6,7,8 .…”

Section: Introductionmentioning

confidence: 99%

“…ESBL infections in children are associated with longer hospital stays, frequent complications, and increased mortality at higher than adult rates in certain regions 6 . Infancy, children on uroprophylaxis, recent antibiotic usage, recurrent urinary tract infections (UTI), urinary tract anomalies, non-renal comorbidities and male gender should guide antibiotic therapy pending culture results in ESBL UTI children 6,7,8 . Fastidious hygiene, patient isolation, cohorting, dedicated staff and alternating antibiotic regimen policies were all employed to control outbreaks of ESBL infection with varying degrees of success.…”

Section: Introductionmentioning

confidence: 99%

“…Fastidious hygiene, patient isolation, cohorting, dedicated staff and alternating antibiotic regimen policies were all employed to control outbreaks of ESBL infection with varying degrees of success. The drug with preserved efficacy for ESBL producers and non-ESBL producers is nitrofurantoin 6 .…”

Section: Introductionmentioning

confidence: 99%

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Risk factors and outcome of urinary tract infections by extended spectrum beta lactamase producing microorganisms in children

Kumar

Lakshmi

2022

Sri Lanka J Child Health

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Objectives: To describe the outcome and risk factors for Urinary Tract Infection (UTI) caused by Extended Spectrum Beta Lactamase (ESBL) producing microorganisms, in children aged 2 months to 15 years, at a tertiary care centre in South India over a period of 1 year.Method: During the study period, there were 352 children with UTI, of which 100 had ESBL UTI and they were included in the study. These 100 children were analysed for risk factors of UTI, nature of treatment, duration of hospital stay and response to treatment and these were recorded in the preformed proforma. Urine routine, urine culture and sensitivity, ultrasonogram, micturating cystourethrogram and dimercapto-succinic acid (DMSA) scan were done for all patients. If colony count was ≥10 5 colony forming units (CFUs) /ml on clean catch sample or urobag sample or any number in catheterized or suprapubic sample with significant ESBL strain growth on urine culture were recorded along with sensitivity pattern. Follow up was done for 3 months.Results: Age and sex distribution of ESBL UTI were 20 (37%) boys and 13 (28.2) girls in the age group 2 months to 2 years, 15 (27.7%) boys and 15 (32.6%) girls in the age group 2 to 5 years, 12 (22.2%) boys and 5 (10.8%) girls in the age group 5 to 10 years and 7 (11.9%) boys and 13 (28.2%) girls in the age group 10 to 15 years. Common risk factors for ESBL UTI in our study were recent antibiotic use within the last 3 months (55%), _________________________________________

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Oral Antibiotics in Clinical Development for Community-Acquired Urinary Tract Infections

2021

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The treatment of urinary tract infections (UTIs) has been complicated by the emergence of multidrug-resistant, b-lactamase-expressing pathogens. As a result of the limited treatment options, patients often require hospitalization and intravenous therapy. In essence, a strong unmet need for oral antibiotics, active against extended-spectrum b-lactamase (ESBL) uropathogens has emerged. Oral carbapenems (tebipenem and sulopenem) and oral cephalosporin/b-lactamase inhibitor combinations are in various stages of clinical development for the treatment of uncomplicated and complicated UTI. Tebipenem, if approved, will be the first oral treatment for complicated UTI while sulopenem will be for uncomplicated UTI. The b-lactamase inhibitors ETX0282, VNRX7145, ARX1796, and QPX7728 are combined with cefpodoxime proxetil or ceftibuten that achieve favorable exposures in urine compared to other uropathogen-active oral cephalosporins.The combination ceftibuten-QPX7728 has potential broad-spectrum coverage against carbapenemase producers including metallo b-lactamase producers. Other novel combinations, namely cefpodoxime/ETX0282, ceftibuten/VNRX-7145, and ceftibuten/ ARX1796, have also demonstrated excellent activity against Klebsiella pneumoniae carbapanemase (KPC) and OXA-48-like producers. All these agents, upon their arrival for commercial use, would strengthen the outpatient therapy.

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Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae Causing Community-Acquired Urinary Tract Infections in Children in Colombia

Cited by 6 publications

References 13 publications

Degree of awareness and practices on urinary tract infections: A study of Sri Lankan school teachers selected from a chronic kidney disease high-prevalent setting

Degree of awareness and practices on urinary tract infections: A study of Sri Lankan school teachers selected from a chronic kidney disease high-prevalent setting

Risk factors and outcome of urinary tract infections by extended spectrum beta lactamase producing microorganisms in children

Oral Antibiotics in Clinical Development for Community-Acquired Urinary Tract Infections

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