Extended-spectrum ?-lactamase production in Klebsiella pneumoniae and Escherichia coli at Jimma University Specialized Hospital, South-West, Ethiopia

Siraj, Shewki Moga; Ali, Solomon; Wondafrash, Beyene

doi:10.5376/mmr.2015.05.0001

Cited by 1 publication

(2 citation statements)

References 27 publications

(27 reference statements)

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“…The observed variation could plausibly be from various characteristics like the number of study subjects' methodology. In our study, the prevalence of K. pneumonia (78.6%) and E. coli (52.2%) producing ESBLs which is consistent with the findings of Bahi Dar ( K. pneumonia 69.8% and E. coli 55.2%) [18], Jimma (K. pneumoniae 70.4%, E. coli 27.2%) [15], and in Uganda (K. pneumonia 72.7% and E. coli 58.1%) [23].…”

Section: Discussionsupporting

confidence: 91%

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Study of Plasmid-Mediated Extended-Spectrum Beta-Lactamase-Producing Clinical Strains of Enterobacteriaceae From Tabuk Region

Alqahtani,

Alelyani,

Yousuf

et al. 2023

Cureus

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Background: Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae threaten infection treatment globally. This study aims to assess ESBLs-E prevalence and multidrug-resistant organisms (MDR) in clinical specimens from Tabuk, KSA. Methods: A cross-sectional research was carried out in March-May 2023. A collective of 90 Enterobacteriaceae isolates were identified from clinical specimens. The specimen was identified by standard methods. The Enterobacteriaceae member was screed for ESBL production by screening and confirmatory as per the Clinical and Laboratory Standards Institute (CLSI). Result: E. coli was the most common isolate, followed by Proteus mirabilis and Citrobacter sp , Klebsiella oxytoca , Klebsiella pneumonia , Proteus vulgaris and Morganella morganii . Among the sample, the majority of isolates were from urine (47.8%) followed by pus (25.6%) and the least from other body fluids (6.7%). The E. coli showed the highest average antibiotic resistance (73.7%) among all the antibiotics used followed by P. mirabilis (70.4%), K. pneumoniae (70%), P. vulgaris (69.8%), M. morganii and Citrobacter (69.4% both), and K. oxytoca (68.8%). There was a 41.2% average reduction in ESBL positivity from phenotypic to confirmatory test results. The highest reduction was observed among M. morganii (66.7%) and the least was observed in E. coli (17.1%). Conclusion: Most of the ESBL-producing isolates were found mainly in blood and urine samples. The most frequent ESBL-producing Enterobacteriaceae were K. pneumoniae and E. coli . The best options for treating Enterobacteriaceae that produce ESBL are Amoxicillin, Amikacin, and Cefoxitin. ESBL-producing isotopes showed a high resistance rate to cefepime and cefotaxime compared to non-ESBL producers. It is of utmost importance to implement reliable infection control measures in healthcare institutions nationwide.

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Section: Discussionsupporting

confidence: 91%

“…The report provided information on the occurrence of ESBL-producing Enterobacteriaceae, indicating that the prevalence rates were at 34%. According to Siraj et al, there was a 4% increase in Jamma [ 15 ]. According to a study conducted by Mululem Ya et al [ 16 ], 36% of individuals surveyed in Jamma exhibited a particular characteristic.…”

Section: Discussionmentioning

confidence: 99%

Study of Plasmid-Mediated Extended-Spectrum Beta-Lactamase-Producing Clinical Strains of Enterobacteriaceae From Tabuk Region

Alqahtani,

Alelyani,

Yousuf

et al. 2023

Cureus

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Extended-spectrum ?-lactamase production in Klebsiella pneumoniae and Escherichia coli at Jimma University Specialized Hospital, South-West, Ethiopia

Abstract: Background: Extended spectrum beta (β)-lactamase (ESBLs) have emerged as a major threat worldwide with limited treatment options. The prevalence of ESBL producing Escherichia coli and Klebsiella pneumoniae strains largely remain unknown in Ethiopia.

Cited by 1 publication

References 27 publications

Study of Plasmid-Mediated Extended-Spectrum Beta-Lactamase-Producing Clinical Strains of Enterobacteriaceae From Tabuk Region

Study of Plasmid-Mediated Extended-Spectrum Beta-Lactamase-Producing Clinical Strains of Enterobacteriaceae From Tabuk Region

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