Extended-spectrum  -lactamase-producing Enterobacteriaceae in different environments (humans, food, animal farms and sewage)

Mesa, Raúl Jesús; Blanc, Vanessa; Blanch, Anicet R.; Cortés, Pilar; González, Juan José; Lavilla, Susana; Miró, Elisenda; Muniesa, Maite; Saco, Montserrat; Tórtola, M. Teresa; Mirelis, Beatriz; Coll, Pere; Llagostera, Montserrat; Prats, Guillem; Navarro, Ferrán

doi:10.1093/jac/dkl211

Cited by 210 publications

(171 citation statements)

References 15 publications

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“…were found in 5 of 10 samples produced in Brazil (CTX-M-2 is widely reported in human infection with Salmonella and E. coli from South America), whereas only 1 of 62 samples of UK produced chicken were positive for CTX-M-1 (Ensor, 2007) ESBLs were also discovered in samples from 8 of 10 pig farms, 2 of 10 rabbit farms, from all 10 poultry farms tested and in 3 of 738 food samples studied in Spain (Mesa et al, 2006).…”

Section: E Coli Strains Producing An Extended Spectrum β-Lactamase (mentioning

confidence: 94%

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Antibiotic Resistance in the Environment, with Particular Reference to MRSA

Gaze

O’Neill

Wellington

et al. 2008

Advances in Applied Microbiology

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Section: E Coli Strains Producing An Extended Spectrum β-Lactamase (mentioning

confidence: 94%

“…ESBL-producing Enterobacteriaceae were detected in five samples of human sewage in Spain (Mesa et al, 2006).…”

Section: Antibiotics and Resistance Genes In The Environmentmentioning

confidence: 99%

Antibiotic Resistance in the Environment, with Particular Reference to MRSA

Gaze

O’Neill

Wellington

et al. 2008

Advances in Applied Microbiology

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“…Clinicians are already facing the tremendous challenges posed by this situation, in terms of the detection and isolation of patients to prevent further nosocomial expansion, and of the choice of empiric antibiotic therapy [38][39][40]. An additional potential reservoir of resistant bacteria and genetic determinants of resistance which intersects with the community is the food supply, as illustrated by the finding of diverse ESBL-producing bacteria, including CTX-M-15, in poultry and other farm animals [41][42][43]. Finally, the origin of CTX-M enzymes probably lies in beta-lactamases found in environmental species, like Kluyvera spp.…”

Section: The Emerging Threat Of Ctx-m Beta-lactamases In the Communitymentioning

confidence: 99%

The continuing challenge of ESBLs

Pérez

Endimiani

Hujer

et al. 2007

Current Opinion in Pharmacology

262

209

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Summary of recent advancesSince their first description more than twenty years ago, Escherichia coli and Klebsiella pneumoniae possessing extended-spectrum class A beta-lactamases (ESBLs) continue to thwart our best clinical efforts. In the "early years" the most common beta-lactamases were of the TEM and SHV varieties. Now, CTX-M enzymes are being discovered though out the world and are becoming the most prevalent beta-lactamases found in clinical isolates. The Klebsiella pneumoniae carbapenemases (KPC) (ESBL type enzymes that confer resistance to extended spectrum cephalosporins and carbapenems) present the most significant challenge to date. Structural studies of ESBLs indicate that active site expansion and remodeling are responsible for this extended hydrolytic activity. Continuing questions still exist regarding the optimal detection method for ESBLs. Most relevant are the increasing concerns regarding the status of carbapenems as "best therapy" for ESBL producing bacteria in light of the emergence of carbapenemases.

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“…Antibiotic-resistant bacteria, including ESBL-producing Enterobacteriaceae, have been detected in food animals, meats, water, and the environment in many Asian countries, including China, Hong Kong, India, Bangladesh, and Malaysia, and could be reservoirs for colonization and infection of human beings. [18][19][20][21][22][23][24][25][26][27][28] There are several previous microbiological surveys of food animals on farms, fresh meat samples from slaughterhouses and retail stores, exported fresh meat samples and vegetables, and stool samples from both healthy individuals and hospital patients from Thailand and several other countries. [29][30][31][32][33][34][35][36][37][38][39][40][41] Almost all of these reports emphasized the ability of foodborne bacteria in causing gastrointestinal infections, especially Salmonella, Campylobacter, and Arcobacter species, though only a few studies described antibiotic-resistant E. coli.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of antibiotic resistant bacteria in healthy adults, foods, food animals, and the environment in selected areas in Thailand

Boonyasiri

Tangkoskul

Seenama

et al. 2014

Pathogens and Global Health

128

110

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Objectives: The aim of this study was to determine the prevalence of antibiotic-resistant bacteria, especially extended-spectrum beta-lactamase (ESBL) producing Escherichia coli, in samples from healthy adults, foods, food animals, and the environment in selected areas of Thailand. Methods: Samples were collected from stool specimens from adult food factory and food animal farm workers, fresh and cooked foods sold at markets, rectal swabs of healthy pigs and chickens, fresh pork meat from slaughterhouses, water samples from canals as well as fish and shrimp farm ponds, and stagnant water sources on pig farms. Antibiotic susceptibility was determined using the disk diffusion or agar dilution methods. Extended-spectrum beta-lactamase production was assayed using a double disk diffusion method. Results: Among 544 healthy adult food factory workers, 75.5% were positive for ESBL producing E. coli, while 77.3% of E. coli isolated from 30 healthy animal farm workers were positive. Amongst healthy food animals, ESBL producing status among E. coli isolates were more commonly detected in pigs (76.7%) than broilers (40%). Extended-spectrum beta-lactamase producing E. coli seemed to be more prevalent in fresh meat samples than in fresh vegetables, in fresh foods than in cooked foods, and in water samples collected from the animal farms than those from canals and fish and shrimp ponds. Conclusions: Extended-spectrum beta-lactamase producing E. coli isolates are prevalent amongst healthy individuals, foods along the food production chain from farms to consumers, and in the environment in selected areas in Thailand.

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Extended-spectrum -lactamase-producing Enterobacteriaceae in different environments (humans, food, animal farms and sewage)

Abstract: This widespread occurrence of ESBL-producing Enterobacteriaceae suggests that the community could act as a reservoir and that food could contribute to the spread of these strains.

Cited by 210 publications

References 15 publications

Antibiotic Resistance in the Environment, with Particular Reference to MRSA

Antibiotic Resistance in the Environment, with Particular Reference to MRSA

The continuing challenge of ESBLs

Prevalence of antibiotic resistant bacteria in healthy adults, foods, food animals, and the environment in selected areas in Thailand

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