Extended Spectrum ??-Lactamase-Positive Escherichia coli Bacteremia Complicating Rotavirus Gastroenteritis

Mel, Eran; Nahum, Elhanan; Lowenthal, Alexander; Ashkenazi, Shai

doi:10.1097/01.inf.0000238134.57950.51

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…In infants, RV infection has been described as a cause of pneumatosis intestinalis, hemorrhagic gastroenteritis, necrotizing enterocolitis and secondary BSI with mainly pathogens belonging to the intestinal microflora and the members of the Enterobacteriaceae family [24-29,33,34]. In our cohort, many of the 20 patients with secondary BSI were preterm infants or patients with compromised immune system and showed BSI due to Staphylococcus aureus .…”

Section: Discussionmentioning

confidence: 88%

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The impact of Rotavirus mass vaccination on hospitalization rates, nosocomial Rotavirus gastroenteritis and secondary blood stream infections

et al. 2013

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BackgroundThe aim of the study was to evaluate the effects of universal mass vaccination (UMV) against rotavirus (RV) on the hospitalization rates, nosocomial RV infections and RV-gastroenteritis (GE)-associated secondary blood stream infections (BSI).MethodsThe retrospective evaluation (2002–2009) by chart analysis included all clinically diagnosed and microbiologically confirmed RV-GE cases in a large tertiary care hospital in Austria. The pre-vaccination period (2002–2005) was compared with the recommended and early funded (2006–2007) and the funded (2008–2009) vaccination periods. Primary outcomes were RV-GE-associated hospitalizations, secondary outcomes nosocomial RV disease, secondary BSI and direct hospitalization costs for children and their accompanying persons.ResultsIn 1,532 children with RV-GE, a significant reduction by 73.9% of hospitalized RV-GE cases per year could be observed between the pre-vaccination and the funded vaccination period, which was most pronounced in the age groups 0–11 months (by 87.8%), 6–10 years (by 84.2%) and 11–18 years (88.9%). In the funded vaccination period, a reduction by 71.9% of nosocomial RV-GE cases per year was found compared to the pre-vaccination period. Fatalities due to nosocomial RV-GE were only observed in the pre-vaccination period (3 cases). Direct costs of hospitalized, community-acquired RV-GE cases per year were reduced by 72.7% in the funded vaccination period. The reduction of direct costs for patients (by 86.9%) and accompanying persons (86.2%) was most pronounced in the age group 0–11 months.ConclusionsUMV may have contributed to the significant decrease of RV-GE-associated hospitalizations, to a reduction in nosocomial RV infections and RV-associated morbidity due to secondary BSI and reduced direct hospitalization costs. The reduction in nosocomial cases is an important aspect considering severe disease courses in hospitalized patients with co-morbidities and death due to nosocomial RV-GE.

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Section: Discussionmentioning

confidence: 88%

“…RV-damaged enterocytes are more capable for bacterial invasion causing secondary bacterial infections [23,24]. Only few studies exist thus far which focus on secondary blood stream infections (BSI) as one major and life-threatening complication following RV-GE [24-29]. …”

Section: Introductionmentioning

confidence: 99%

The impact of Rotavirus mass vaccination on hospitalization rates, nosocomial Rotavirus gastroenteritis and secondary blood stream infections

et al. 2013

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“…Severe courses of RV+ AGE have been reported in immunocompromised children and adults [9,36,43,44]. Other complications may result from secondary bacteremia, mostly Gram-negative, probably via mucosal damage as a result of RV+ AGE [1,4,5,21,[25][26][27]29]. Up to one third of cases of necrotizing enterocolitis in preterm infants are associated with RV infection [22,41].…”

Section: Introductionmentioning

confidence: 97%

Complications in hospitalized children with acute gastroenteritis caused by rotavirus: a retrospective analysis

et al. 2011

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“…1 Costly microbiological assays are frequently performed in these patients to exclude concurrent serious bacterial infection (SBI), though the actual incidence of SBI is quite low. [2][3][4][5][6][7][8] Our objectives were to describe the incidence of SBI in children evaluated at a community hospital and subsequently diagnosed with laboratoryconfirmed RGE and to determine whether ancillary testing was associated with prolonged length of stay (LOS) in hospitalized patients.…”

Section: Abstract: Resource Utilization Rotavirus Serious Bacterialmentioning

confidence: 99%

Ancillary testing in children with rotavirus gastroenteritis

Rowinsky

Steenhoff

Kung

et al. 2009

Journal of Hospital Medicine

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Extended Spectrum ??-Lactamase-Positive Escherichia coli Bacteremia Complicating Rotavirus Gastroenteritis

Cited by 9 publications

References 6 publications

The impact of Rotavirus mass vaccination on hospitalization rates, nosocomial Rotavirus gastroenteritis and secondary blood stream infections

The impact of Rotavirus mass vaccination on hospitalization rates, nosocomial Rotavirus gastroenteritis and secondary blood stream infections

Complications in hospitalized children with acute gastroenteritis caused by rotavirus: a retrospective analysis

Ancillary testing in children with rotavirus gastroenteritis

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