Extended-Spectrum Beta-Lactamase (ESBL)–Producing Gram-negative Isolates from Urine and Wound Specimens in a Tertiary Health Facility in Southern Nigeria

Ogefere, Helen Oroboghae; Aigbiremwen, Patience A.; Omoregie, Richard

doi:10.4314/tjpr.v14i6.22

Cited by 38 publications

(46 citation statements)

References 19 publications

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“…Wound and urinary specimens form the largest group of clinical specimens received in microbiology laboratories as was the case in this study. 9 Our finding compares with previous studies which have shown that most GNB recovered from urine and wounds are ESBL-producing and another in which urine samples had the highest prevalence of MBL producing bacteria. 3,9 The carbapenems (imipenem and meropenem) which were the most effective antibiotics in this study showed activity against ESBL and AmpC β-lactamase producing GNBs.…”

Section: Discussioncontrasting

confidence: 56%

“…9 Our finding compares with previous studies which have shown that most GNB recovered from urine and wounds are ESBL-producing and another in which urine samples had the highest prevalence of MBL producing bacteria. 3,9 The carbapenems (imipenem and meropenem) which were the most effective antibiotics in this study showed activity against ESBL and AmpC β-lactamase producing GNBs. The carbapenems are expensive drugs of last resort in our region and have shown good activity against GNB producing both enzymes.…”

Section: Discussioncontrasting

confidence: 56%

“…This finding is at variance with several Nigerian studies which showed Enterobacter species and Klebsiella species as the most prevalent ESBL producers, 9,15 Enterobacter spp. was however not recovered from clinical samples during the period of this study.…”

Section: Discussioncontrasting

confidence: 55%

“…This finding is in contrast with another study in this facility which observed that the prevalence of ESBL did not differ significantly in GNB recovered from inpatients in comparison with out-patients. 9 It, however, aligns with another study. 18 A study in south-western Nigeria recovered 35% of ESBL producing strains from community dwellers while 65% were recovered from samples of inpatients.…”

Section: Discussionmentioning

confidence: 35%

“…2,8 In Nigeria, indiscriminate use of antibiotics, poor hygienic practices in hospitals and lack of monitoring of microbial drug resistance may have exerted selective pressure, leading to the emergence of ESBLs, AmpC and recently MBL enzymes. 7,9 Indeed, these enzymes have demonstrated varying prevalence rates in southeastern and north-western Nigeria. 3,6 Paucity of data on the prevalence of AmpC β-lactamase and metallo-β-lactamase (MBL) in South-South Nigeria coupled with the fact that no previous study in our environment had looked for these three enzymes simultaneously necessitated this study.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Prevalence of Extended Spectrum β-Lactamase, AmpC β-Lactamase and Metallo-β-Lactamase Among Gram Negative Bacilli Recovered From Clinical Specimens in Benin City, Nigeria

Ibadin¹,

Omoregie²,

Anogie³

et al. 2017

Int J Enteric Pathog

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Section: Discussioncontrasting

confidence: 56%

Section: Discussioncontrasting

confidence: 56%

Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 35%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of Extended Spectrum β-Lactamase, AmpC β-Lactamase and Metallo-β-Lactamase Among Gram Negative Bacilli Recovered From Clinical Specimens in Benin City, Nigeria

Ibadin¹,

Omoregie²,

Anogie³

et al. 2017

Int J Enteric Pathog

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Molecular epidemiology of extended-spectrum beta-lactamase–producing extra-intestinal pathogenic Escherichia coli strains over a 2-year period (2017–2019) from Zimbabwe

Takawira

Pitout

Thilliez

et al. 2021

Eur J Clin Microbiol Infect Dis

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This study was designed to characterize extended-spectrum beta-lactamase (ESBL)producing extra-intestinal pathogenic Escherichia coli (E.coli) (ExPEC) associated with urinary tract infections in nine different geographic regions of Zimbabwe over a 2-year period (2017)(2018)(2019). A total of 48 ESBL-positive isolates from urine specimen were selected for whole-genome sequencing from 1246 Escherichia coli isolates biobanked at the National Microbiology Reference laboratory using phenotypic susceptibility testing results from the National Escherichia coli Surveillance Programme to provide representation of different geographical regions and year of isolation. The majority of ESBL E. coli isolates produced cefotaximase-Munich (CTX-M)-15, CTX-M-27, and CTX-M-14. In this study, sequence types (ST) 131 and ST410 were the most predominant antimicrobial-resistant clones and responsible for the increase in ESBL-producing E. coli strains since 2017. Novel ST131 complex strains were recorded during the period 2017 to 2018, thus showing the establishment and evolution of this antimicrobial-resistant ESBL clone in Zimbabwe posing an important public health threat. Incompatibility group F plasmids were predominant among ST131 and ST410 isolates with the following replicons recorded most frequently: F1:A2:B20 (9/19, 47%), F2:A1: B (5/19, 26%), and F1:A1:B49 (8/13, 62%). The results indicate the need for continuous tracking of different ESBL ExPEC clones on a global scale, while targeting specific STs (e.g. ST131 and ST410) through control programs will substantially decrease the spread of ESBLs among ExPEC.

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Utilization of surgical antibiotic prophylaxis for obstetrics and gynaecology surgeries in Northern Nigeria

2018

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Background Audit of antibiotic prophylaxis is an important strategy used to identify areas where stewardship interventions are required. Objectives To evaluate compliance with surgical antibiotic prophylaxis in obstetrics and gynaecology surgeries and determine the Defined Daily Dose (DDD) of antibiotic. Settings Three public tertiary hospitals located in Northern Nigeria. Methods This prospective study included women who had obstetrics and gynaecology surgeries with no infection at the time of incision. Appropriateness of antibiotic prophylaxis was determined by a clinical pharmacist. DDD of antibiotics was determined using ATC/DDD index 2017 from the World Health Organization Collaborating Centre for Drugs Statistics Methodology. Main outcome measure Compliance with antibiotic prophylaxis and DDD of antibiotic per procedure. Results A total of 248 procedures were included (mean age: 31.7 ± 7.9 years). Nitroimidazole in combination with either beta-lactam/beta-lactamase inhibitor or third generation cephalosporin were the most prescribed antibiotics. Redundant anaerobic antibiotic combination was detected in 71.4% of the procedures. Timing of antibiotic prophylaxis was optimal in 16.5% while duration of prophylaxis was prolonged in all the procedures (mean duration was 8.7 ± 1.0 days). The DDD of antibiotics prophylaxis was 16.75 DDD/procedure. Antibiotic utilisation was higher in caesarean section and myomectomy (17.9 DDD/procedure) than hysterectomy (14.5 DDD/procedure); P < 0.001. Redundant metronidazole represents one-third of total DDD and 87% of the DDD for metronidazole. Conclusion Excessive and inappropriate use of antibiotic prophylaxis was observed in women who had obstetrics and gynaecology surgeries. These observations underline the need for antimicrobial stewardship interventions to improve antibiotic use.

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Extended-Spectrum Beta-Lactamase (ESBL)–Producing Gram-negative Isolates from Urine and Wound Specimens in a Tertiary Health Facility in Southern Nigeria

Abstract: Purpose: To determine the prevalence of extended spectrum beta lactamase (ESBL)

Cited by 38 publications

References 19 publications

Prevalence of Extended Spectrum β-Lactamase, AmpC β-Lactamase and Metallo-β-Lactamase Among Gram Negative Bacilli Recovered From Clinical Specimens in Benin City, Nigeria

Prevalence of Extended Spectrum β-Lactamase, AmpC β-Lactamase and Metallo-β-Lactamase Among Gram Negative Bacilli Recovered From Clinical Specimens in Benin City, Nigeria

Molecular epidemiology of extended-spectrum beta-lactamase–producing extra-intestinal pathogenic Escherichia coli strains over a 2-year period (2017–2019) from Zimbabwe

Utilization of surgical antibiotic prophylaxis for obstetrics and gynaecology surgeries in Northern Nigeria

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