Extended-Spectrum B-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands

Overdevest, Ilse; Willemsen, Ina; Rijnsburger, Martine; Eustace, Andrew; Xu, Li; Hawkey, Peter M.; Heck, Max; Savelkoul, Paul H. M.; Vandenbroucke-Grauls, Christina M. J. E.; Zwaluw, Kim van der; Huijsdens, Xander W.; Kluytmans, Jan

doi:10.3201/eid1707.110209

Cited by 518 publications

(468 citation statements)

References 29 publications

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“…This finding is supported by data from our study: 50% of participants who had a positive pretravel sample had traveled during the previous 12 months. This high percentage of carriers identified in this study before travel points toward ongoing importation of ESBL-E. Other potential reservoirs for ESBL-E are poultry and other retail meats, which have been found to be contaminated with ESBL-producing E. coli strains harboring the genes on identical plasmids as found in human isolates ( 15 , 16 ). …”

Section: Discussionmentioning

confidence: 63%

Extended-Spectrum β-Lactamase–producingEnterobacteriaceaeamong Travelers from the Netherlands

Paltansing¹,

Vlot²,

Kraakman³

et al. 2013

Emerg. Infect. Dis.

112

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A prospective cohort study was performed among travelers from the Netherlands to investigate the acquisition of carbapenemase-producing Enterobacteriaceae (CP-E) and extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBL-E) and associated risk factors. Questionnaires were administered and rectal swab samples were collected and tested before and after traveler return. Of 370 travelers, 32 (8.6%) were colonized with ESBL-E before trave,; 113 (30.5%) acquired an ESBL-E during travel, and 26 were still colonized 6 months after return. No CP-E were found. Independent risk factors for ESBL-E acquisition were travel to South and East Asia. Multilocus sequence typing showed extensive genetic diversity among Escherichia coli. Predominant ESBLs were CTX-M enzymes. The acquisition rate, 30.5%, of ESBL-E in travelers from the Netherlands to all destinations studied was high. Active surveillance for ESBL-E and CP-E and contact isolation precautions may be recommended at admission to medical facilities for patients who traveled to Asia during the previous 6 months.

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Section: Discussionmentioning

confidence: 63%

Extended-Spectrum β-Lactamase–producingEnterobacteriaceaeamong Travelers from the Netherlands

Paltansing¹,

Vlot²,

Kraakman³

et al. 2013

Emerg. Infect. Dis.

112

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“…A large proportion of resistant isolates causing human infections are derived from food animals ( 3 – 6 ). However, lack of data has made it difficult to quantify the proportion of antimicrobial drug resistant E. coli infecting persons through food sources and the resultant effects on human health.…”

mentioning

confidence: 99%

“…However, lack of data has made it difficult to quantify the proportion of antimicrobial drug resistant E. coli infecting persons through food sources and the resultant effects on human health. Recent data from the Netherlands now make such estimates possible ( 2 , 6 ). The additional illness and death among humans resulting from bloodstream infections caused by third-generation cephalosporin–resistant E. coli (G3CREC) has been calculated for Europe ( 2 ).…”

mentioning

confidence: 99%

“…In the Netherlands, there were 205 G3CREC cases during 2007 (4% of all E. coli bloodstream infections) ( 2 ). Another study in the Netherlands revealed that 56% of the resistance genes in G3CREC in humans were identical to genes derived from E. coli isolated from retail chicken samples ( 6 ). Using the findings of Overdevest et al ( 6 ) and de Kraker et al ( 2 ), we calculated that, in the Netherlands, infections in humans with G3CREC derived from poultry sources were associated with 21 additional deaths.…”

mentioning

confidence: 99%

“…Another study in the Netherlands revealed that 56% of the resistance genes in G3CREC in humans were identical to genes derived from E. coli isolated from retail chicken samples ( 6 ). Using the findings of Overdevest et al ( 6 ) and de Kraker et al ( 2 ), we calculated that, in the Netherlands, infections in humans with G3CREC derived from poultry sources were associated with 21 additional deaths. G3CREC-related illness also resulted in 908 hospital bed-days needed to treat persons with these antimicrobial drug resistant bloodstream infections.…”

mentioning

confidence: 99%

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Human Deaths and Third-Generation Cephalosporin use in Poultry, Europe

Collignon¹,

Aarestrup²,

Irwin³

et al. 2013

Emerg. Infect. Dis.

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Assessment of Factors Associated With Community-Acquired Extended-Spectrum β-Lactamase–Producing Escherichia coli Urinary Tract Infections in France

Paumier¹,

Asquier-Khati

Thibaut

et al. 2022

JAMA Netw Open

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ImportanceExtended-spectrum β-lactamase (ESBL)–producing Escherichia coli is considered a leading pathogen contributing to the global burden of antimicrobial resistance.ObjectiveTo better understand factors associated with the heterogeneity of community-acquired ESBL-producing E coli urinary tract infections (UTIs) in France.Design, Setting, and ParticipantsThis cross-sectional study performed from January 1 to December 31, 2021, was based on data collected via PRIMO (Surveillance and Prevention of Antimicrobial Resistance in Primary Care and Nursing Homes), a nationwide clinical laboratory surveillance system in France. Strains of E coli isolated from community urine samples from January 1 to December 31, 2019, from 59 administrative departments of metropolitan France were included.Main Outcomes and MeasuresQuasi-Poisson regression models were used to assess the associations between several ecological factors available on government and administration websites between 2010 and 2020 (demographic population structure, living conditions, baseline health care services, antibiotic consumptions, economic indicators, animal farming density, and environmental characteristics) and the number of ESBL-producing E coli strains isolated from urine samples of individuals with community-acquired UTI in 2019.ResultsAmong 444 281 E coli isolates from urine samples tested in 1013 laboratories, the mean prevalence of ESBL-producing E coli was 3.0% (range, 1.4%-8.8%). In an adjusted model, the number of community-acquired ESBL-producing E coli UTIs in each department was positively associated with the percentage of children younger than 5 years (adjusted β1 coefficient, 0.112 [95% CI, 0.040-0.185]; P = .004), overcrowded households (adjusted β1 coefficient, 0.049 [95% CI, 0.034 to 0.062]; P < .001), consumption of fluoroquinolones (adjusted β1 coefficient, 0.002 [95% CI, 0.001-0.002]; P < .001), and tetracyclines (adjusted β1 coefficient, 0.0002 [0.00004 to 0.00039]; P = .02), and poultry density (adjusted β1 coefficient, 0.0001 [95% CI, 0.0001-0.0002]; P < .001). The social deprivation index (adjusted β1 coefficient, −0.115 [95% CI, −0.165 to −0.064]; P < .001) and the proportion of water surface area (adjusted β1 coefficient, −0.052 [−0.081 to −0.024]; P = .001) were negatively associated with a higher number of community-acquired ESBL-producing E coli UTIs.Conclusions and RelevanceThe findings of this cross-sectional study suggest that multiple human health, animal health, and environmental factors are associated with the occurence of community-acquired ESBL E coli UTI. Strategies to mitigate ESBL in the community should follow the One Health approach and address the role played by fluoroquinolones, tetracycline use, poultry density, overcrowded households, and preschool-aged children.

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Extended-Spectrum B-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands

Cited by 518 publications

References 29 publications

Extended-Spectrum β-Lactamase–producingEnterobacteriaceaeamong Travelers from the Netherlands

Extended-Spectrum β-Lactamase–producingEnterobacteriaceaeamong Travelers from the Netherlands

Human Deaths and Third-Generation Cephalosporin use in Poultry, Europe

Assessment of Factors Associated With Community-Acquired Extended-Spectrum β-Lactamase–Producing Escherichia coli Urinary Tract Infections in France

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