Extended Somatostatin Treatment of a Patient with Bleeding Ulcer

Mattes, P; Raptis, Sotirios A.; Heil, T; Rasche, H; Scheck, Raffael

doi:10.1055/s-0028-1093714

Cited by 38 publications

(9 citation statements)

References 3 publications

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“…Noteworthy in Somatostatin and Splanchnic Glucose Metabolism this context is the report that the administration of somatostatin was followed by cessation of gastrointestinal bleeding in a patient with peptic ulcer (36). With the technique employed for flow measurement in the present study it is not possible to distinguish between changes in arterial hepatic as opposed to portal venous blood flow.…”

Section: Resultscontrasting

confidence: 38%

Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-hour fasted humans.

Wahren¹,

Efendić²,

Luft³

et al. 1977

J. Clin. Invest.

129

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A B S T R A C T Cyclic somatostatin was administered intravenously (10 ,ug/min for 60 min) to 10 healthy overnight fasted (postabsorptive) subjects and to 5 healthy 60-h fasted subjects. In both groups, arterial insulin and glucagon fell 50%o and splanchnic release of these hormones was inhibited. In the overnight fasted subjects splanchnic glucose output fell 70%, splanchnic uptake of lactate and pyruvate was unchanged, alanine uptake fell by 25%, and glycerol uptake rose more than twofold in parallel with an increase in arterial glycerol.In the 60-h fasted group splanchnic glucose output was less than 40%o of that observed in the overnight fasted subjects. Somatostatin led to a further decrease (-70%) in glucose production. Splanchnic uptake of lactate and pyruvate fell by 30-40%o, amino acid uptake was unchanged, while uptake of glycerol rose fivefold. Total uptake of glucose precursors thus exceeded the simultaneous glucose output by more than 200%o. Splanchnic uptake of FFA rose fourfold during somatostatin while output of beta-hydroxybutyrate increased by 75%. Estimated hepatic blood flow fell 25-35% and returned to base line as soon as the somatostatin infusion ended.It is concluded that (a) somatostatin-induced hypoglucagonemia results in inhibition of splanchnic Dr. Felig is the recipient ofa Research Career Devleopment Award

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Section: Resultscontrasting

confidence: 38%

Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-hour fasted humans.

Wahren¹,

Efendić²,

Luft³

et al. 1977

J. Clin. Invest.

129

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“…In an previous paper we have been able to show the therapeutic effect of Somatostatin in stress ulcer hemorrhage [6]. The present study demonstrates that prophylactic Somatostatin application in immobilisation-hypoxia-stress of the rat is capable of lowering conspicuously the incidence rate of stress-induced ulcers.…”

Section: Discussionmentioning

confidence: 60%

Prevention of stress ulcer by Somatostatin in rats

Mattes

Lauterbach

Raptis

1976

Langenbecks Arch Chiv

Self Cite

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In animal experiments it was examined, to what extent prophylactic application of Somatostatin is able to prevent the stress-induced ulcer of the rat. 32 male Wistar rats were exposed to a combined immobilisation-hypoxia-stress. Somatostatin was given intraperitoneally as bolus and intravenously as a continuous infusion. The results indicated that Somatostatin lowers significantly the incidence rate of stress-induced gastric ulcers in the rat.

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“…SS may be considered to be a potent vasoconstrictor of intestinal circulation, counteracting the well-known vasodilatory action of major gastro-intestinal hormones such as gastrin, secretin, cholecystokinin, and vasoactive intestinal polypeptide (19). This effect may be of clinical importance because of the possible usefulness of SS in the control of gastrointestinal-hemorrhages (20). The vasoconstrictor effect of SS is transient.…”

Section: Discussionmentioning

confidence: 99%