Abstract:Alcohol dehydrogenases (ADH) are important tools for generating chiral α‐hydroxyketones. Previously, only the ADH of Thauera aromatica was known to convert cyclic α‐diketones with appropriate preference. Here, we extend the spectrum of suitable enzymes by three alcohol dehydrogenases from Citrifermentans bemidjiense (CibADH), Deferrisoma camini (DecADH), and Thauera phenylacetica (ThpADH). Of these, DecADH is characterized by very high thermostability; CibADH and ThpADH convert α‐halogenated cyclohexanones wit… Show more
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