Extended Prandial Glycemic Profiles of Foods as Assessed Using Continuous Glucose Monitoring Enhance the Power of the 120-Minute Glycemic Index

Chlup, Rudolf; Peterson, Karolina; Zapletalová, Jana; Kudlová, Pavla; Seckar, Pavel

doi:10.1177/193229681000400316

Cited by 13 publications

(10 citation statements)

References 45 publications

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“…After various types of food consumption, glycaemia remains above the baseline for a longer period, and the CGMS is a convenient method to determine the glucose response. We observed this in the post-meal reaction over 180 minutes, which was a compatible with the result obtained by Chlup [20].…”

Section: Discussionsupporting

confidence: 93%

Improving the Estimation of Meal-Time Insulin Dose Based On the Glycaemic Load of a Meal in Children with Type 1 Diabetes on Insulin Pump Therapy: A Randomized Study

Błazik¹

2014

J Diabetes Metab

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Section: Discussionsupporting

confidence: 93%

Improving the Estimation of Meal-Time Insulin Dose Based On the Glycaemic Load of a Meal in Children with Type 1 Diabetes on Insulin Pump Therapy: A Randomized Study

Błazik¹

2014

J Diabetes Metab

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“…The development of CGMS technology is a great step toward modern diabetes management 13 . CGMS has also been used to investigate the glycaemic indexes of food at different times of the day 14,15 . This overcomes the limitations of traditional monitoring by producing glucose profiles instead of distinct measurements, real-time glucose values, glucose trends and warnings when glucose values approach dangerously low or high concentrations.…”

Section: Introductionmentioning

confidence: 99%

Glucose concentrations in blood and tissue - a pilot study on variable time lag

Chlup¹,

Krejčí²,

O’Connell³

et al. 2015

BIOMED PAP

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Aim. The aim of this pilot study was to acquire insight into the parameters of glycaemic control, especially, (1) the time delay (lag phase) between plasma and tissue glucose concentrations in relation to rise and fall in glucose levels and (2) the rate of glucose increase and decrease. Methods. Four healthy people (HP), 4 people with type 1diabetes (DM1) and 4 with type 2 diabetes (DM2) underwent concurrent glucose measurements by means of (1) the continuous glucose monitoring system (CGMS-Medtronic), Medtronic-Minimed, CA, USA, calibrated by the glucometer Calla, Wellion, Austria, and, (2) the Beckman II analyser to measure glucose concentrations in venous plasma. Samples were taken on 4 consecutive days in the fasting state and 4 times after consumption of 50 g glucose. Carelink Personal, MS Excel, Maple and Mat lab were applied to plot the evolution of glucose concentration and analyse the results. The time difference between increase and decrease was calculated for HP, DM 1 and DM 2. Results. In DM1and DM2, glucose tolerance testing (GTT) resulted in slower transport of glucose into subcutaneous tissue than in HP where the lag phase lasted up to 12 min. The maximum increase/decrease rates in DM1 and DM2 vs HP were 0.25 vs < 0.1 mmol/L/min. Conclusion. CGMS is shown to provide reliable plasma glucose concentrations provided the system is calibrated during a steady state. The analysis of glucose change rates improves understanding of metabolic processes better than standard GTT.

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“…Nevertheless, the evaluation of individual subjects revealed potential influence of OAD on GIs in some persons and some foodstuffs and no or even adverse influence in others. Considering the already known large interindividual variability of GI due to various factors, 22 and recent findings on extended prandial glycemic profiles of foods, 40,41 this observation appears to be worthy of further investigation. In addition, the OAD withdrawal lasted only 8 days, which is a relatively short time, and the effects of OAD may have persisted during this interval.…”

Section: Discussionmentioning

confidence: 99%

Influence of Oral Antidiabetic Drugs on Hyperglycemic Response to Foods in Persons with Type 2 Diabetes Mellitus as Assessed by Continuous Glucose Monitoring System: A Pilot Study

Peterson

Chlup

Zapletalová

et al. 2010

J Diabetes Sci Technol

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Background: The purpose of this prospective open-label trial was (1) to assess the Influence of oral antidiabetic drugs (OAD) on the glycemic index (GI), glucose response curves (GRCs), daily mean plasma glucose (MPG) and (2) to compare the GI of foods in persons with OAD-treated type 2 diabetes mellitus (T2DM) with the respective GI in healthy persons (HP). Methods: Tested foods containing 50 g of carbohydrates were eaten for breakfast and dinner after 10 and 4 h of fasting, respectively. Glycemic index, GRC, and MPG were obtained using the CGMS® System Gold™ (CGMS). In T2DM patients [n = 16; age (mean ± standard error) 56.0 ± 2.25 years], foods were tested four times: tests 1, 2, and 3 were performed within one week in which placebo was introduced on day 2, and test 4 was carried out five weeks after reintroduction of OAD. Glycemic indexes, GRC, and MPG from tests 1, 2, 3, and 4 were compared. In a control group of 20 HP (age 24.4 ± 0.71 years), the mean GIs were calculated as the mean from 20 subject-related GIs. Results: In T2DM patients, subject-related assessment of GIs, GRC, and MPG distinguished persons with and without OAD effect. Nevertheless, the group-related GIs and the MPG on days 2, 8, and 39 showed no significant difference. There was no significant difference between the GIs in OAD-treated T2DM patients (test 4) versus HP (except in apple baby food). Glucose response curves were significantly larger in T2DM patients (test 4) versus HP. Conclusions: Determination of GRC and subject-related GI using the CGMS appears to be a potential means for the evaluation of efficacy of OAD treatment. Further studies are underway.

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Extended Prandial Glycemic Profiles of Foods as Assessed Using Continuous Glucose Monitoring Enhance the Power of the 120-Minute Glycemic Index

Cited by 13 publications

References 45 publications

Improving the Estimation of Meal-Time Insulin Dose Based On the Glycaemic Load of a Meal in Children with Type 1 Diabetes on Insulin Pump Therapy: A Randomized Study

Improving the Estimation of Meal-Time Insulin Dose Based On the Glycaemic Load of a Meal in Children with Type 1 Diabetes on Insulin Pump Therapy: A Randomized Study

Glucose concentrations in blood and tissue - a pilot study on variable time lag

Influence of Oral Antidiabetic Drugs on Hyperglycemic Response to Foods in Persons with Type 2 Diabetes Mellitus as Assessed by Continuous Glucose Monitoring System: A Pilot Study

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