Extended Nicotine Patch Treatment Among Smokers With and Without Comorbid Psychopathology

Carroll, Allison J.; Mathew, Amanda R.; Leone, Frank T.; Wileyto, E. Paul; Miele, Andrew; Schnoll, Robert A.; Hitsman, Brian

doi:10.1093/ntr/nty191

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…There are clear reasons that more intense or multicomponent treatment might be significantly more beneficial than less intensive treatments (Blankers, 2020;Carroll et al, 2020;Driessen et al, 2019;Duffy et al, 2020;Lotfizadeh et al, 2020;Smits et al, 2020). In keeping with this notion, researchers have evaluated such adjuvants as relapse prevention training, social-support interventions, mindfulness content, motivational interviewing (MI) content, cognitive-game interventions, physical-exercise interventions, distraction via computer games, "resistance training," and medicationadherence interventions (e.g., Ciccolo et al, 2014;Fiore et al, 2008;Gruder et al, 1993;Loughead et al, 2016;Schlam & Baker, 2020).…”

Section: Theoretical/methodological/review Articlementioning

confidence: 99%

Barriers to Building More Effective Treatments: Negative Interactions Among Smoking-Intervention Components

Baker

Bolt²,

Smith

2021

Clinical Psychological Science

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Meaningfully improved mental and behavioral health treatment is an unrealized dream. Across three factorial experiments, inferential tests in prior studies showed a pattern of negative interactions, suggesting that better clinical outcomes may be obtained when participants receive fewer rather than more intervention components. Furthermore, relatively few significant main effects were found in these experiments. Modeling suggested that negative interactions among components may account for these patterns. In this article, we evaluate factors that may contribute to such declining benefit: increased attentional or effort burden; components that produce their effects via the same capacity-limited mechanisms, making their effects subadditive; and a tipping-point phenomenon in which people near a hypothesized tipping point for change will benefit markedly from weak intervention and people far from the tipping point will benefit little from even strong intervention. New research should explore factors that cause negative interactions among components and constrain the development of more effective treatments.

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Section: Theoretical/methodological/review Articlementioning

confidence: 99%

Barriers to Building More Effective Treatments: Negative Interactions Among Smoking-Intervention Components

Baker

Bolt²,

Smith

2021

Clinical Psychological Science

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Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation

Theodoulou

Chepkin

et al. 2023

Cochrane Database of Systematic Reviews

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Background Nicotine replacement therapy (NRT) aims to replace nicotine from cigarettes. This helps to reduce cravings and withdrawal symptoms, and ease the transition from cigarette smoking to complete abstinence. Although there is high‐certainty evidence that NRT is effective for achieving long‐term smoking abstinence, it is unclear whether different forms, doses, durations of treatment or timing of use impacts its effects. Objectives To determine the effectiveness and safety of different forms, deliveries, doses, durations and schedules of NRT, for achieving long‐term smoking cessation. Search methods We searched the Cochrane Tobacco Addiction Group trials register for papers mentioning NRT in the title, abstract or keywords, most recently in April 2022. Selection criteria We included randomised trials in people motivated to quit, comparing one type of NRT use with another. We excluded studies that did not assess cessation as an outcome, with follow‐up of fewer than six months, and with additional intervention components not matched between arms. Separate reviews cover studies comparing NRT to control, or to other pharmacotherapies. Data collection and analysis We followed standard Cochrane methods. We measured smoking abstinence after at least six months, using the most rigorous definition available. We extracted data on cardiac adverse events (AEs), serious adverse events (SAEs) and study withdrawals due to treatment. Main results We identified 68 completed studies with 43,327 participants, five of which are new to this update. Most completed studies recruited adults either from the community or from healthcare clinics. We judged 28 of the 68 studies to be at high risk of bias. Restricting the analysis only to those studies at low or unclear risk of bias did not significantly alter results for any comparisons apart from the preloading comparison, which tested the effect of using NRT prior to quit day whilst still smoking. There is high‐certainty evidence that combination NRT (fast‐acting form plus patch) results in higher long‐term quit rates than single form (risk ratio (RR) 1.27, 95% confidence interval (CI) 1.17 to 1.37; I 2 = 12%; 16 studies, 12,169 participants). Moderate‐certainty evidence, limited by imprecision, indicates that 42/44 mg patches are as effective as 21/22 mg (24‐hour) patches (RR 1.09, 95% CI 0.93 to 1.29; I 2 = 38%; 5 studies, 1655 participants), and that 21 mg patches are more effective than 14 mg (24‐hour) patches (RR 1.48, 95% CI 1.06 to 2.08; 1 study, 537 participants). Moderate‐certainty evidence, again limited by imprecision, also suggests a benefit of 25 mg over 15 mg (16‐hour) patches, but the lower limit of the CI encompassed no difference (RR 1.19, 95% CI 1.00 to 1.41; I 2 = 0%; 3 studies, 3446 participants...

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Advancing Our Knowledge in All Stages of Treatment Research Using a Range of Methodologies

Weinberger

2019

Nicotine &Amp; Tobacco Research

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Extended Nicotine Patch Treatment Among Smokers With and Without Comorbid Psychopathology

Abstract: Targeted smoking cessation treatment, rather than extending treatment duration, may be especially warranted to optimize treatment for smokers with comorbid mood, anxiety, and substance use disorders.

Cited by 3 publications

References 47 publications

Barriers to Building More Effective Treatments: Negative Interactions Among Smoking-Intervention Components

Barriers to Building More Effective Treatments: Negative Interactions Among Smoking-Intervention Components

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation

Advancing Our Knowledge in All Stages of Treatment Research Using a Range of Methodologies

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